Imperial College London

professor neil fairweather

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 5247n.fairweather

 
 
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Location

 

1.44Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

125 results found

FAIRWEATHER NF, LYNESS VA, 1986, THE COMPLETE NUCLEOTIDE-SEQUENCE OF TETANUS TOXIN, NUCLEIC ACIDS RESEARCH, Vol: 14, Pages: 7809-7812, ISSN: 0305-1048

JOURNAL ARTICLE

FAIRWEATHER NF, LYNESS VA, PICKARD DJ, ALLEN G, THOMSON ROet al., 1986, CLONING, NUCLEOTIDE SEQUENCING, AND EXPRESSION OF TETANUS TOXIN FRAGMENT-C IN ESCHERICHIA-COLI, JOURNAL OF BACTERIOLOGY, Vol: 165, Pages: 21-27, ISSN: 0021-9193

JOURNAL ARTICLE

DOUGAN G, FAIRWEATHER N, 1985, GENETIC-ANALYSIS OF GRAM-POSITIVE TOXIN DETERMINANTS - THE IMPACT OF NEW TECHNOLOGIES, MICROBIOLOGICAL SCIENCES, Vol: 2, Pages: 144-147, ISSN: 0265-1351

JOURNAL ARTICLE

HERRERO E, FAIRWEATHER NF, HOLLAND IB, 1982, ENVELOPE PROTEIN-SYNTHESIS AND INHIBITION OF CELL-DIVISION IN ESCHERICHIA-COLI DURING INACTIVATION OF THE B-SUBUNIT OF DNA GYRASE, JOURNAL OF GENERAL MICROBIOLOGY, Vol: 128, Pages: 361-369, ISSN: 0022-1287

JOURNAL ARTICLE

Fairweather NF, Orr E, Holland IB, 1980, Inhibition of deoxyribonucleic acid gyrase: effects on nucleic acid synthesis and cell division in Escherichia coli K-12., J Bacteriol, Vol: 142, Pages: 153-161, ISSN: 0021-9193

Mutants of Escherichia coli resistant to the antibiotic clorobiocin are also coumermycin resistant, and the mutation to resistance in at least one mutant was mapped near gyrB. We conclude, therefore, that clorobiocin inhibits deoxyribonucleic acid gyrase, and the drug was used to probe the role of this enzyme in vivo. Deozyribonucleic acid synthesis was preferentially inhibited but not completely blocked by the antibiotic. Transcription and cell division were also markedly affected. However, unlike other inhibitors of deoxyribonucleic acid synthesis, clorobiocin failed to induce the synthesis of protein X, the recA gene product. In mutants resistant to clorobiocin the replication velocity was unaffected, but initiation of deoxyribonucleic acid synthesis appeared to be delayed. We conclude that deoxyribonucleic acid gyrase, and hence the supercoiled structure of the chromosome, is important for transcription, normal initiation of deoxyribonucleic acid replication, and cell division. The possible role of deoxyribonucleic acid gyrase in the elongation of replication forks is also discussed.

JOURNAL ARTICLE

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