126 results found
FAIRWEATHER NF, LYNESS VA, MASKELL DJ, 1987, IMMUNIZATION OF MICE AGAINST TETANUS WITH FRAGMENTS OF TETANUS TOXIN SYNTHESIZED IN ESCHERICHIA-COLI, INFECTION AND IMMUNITY, Vol: 55, Pages: 2541-2545, ISSN: 0019-9567
FAIRWEATHER NF, LYNESS VA, 1986, THE COMPLETE NUCLEOTIDE-SEQUENCE OF TETANUS TOXIN, NUCLEIC ACIDS RESEARCH, Vol: 14, Pages: 7809-7812, ISSN: 0305-1048
FAIRWEATHER NF, LYNESS VA, PICKARD DJ, et al., 1986, CLONING, NUCLEOTIDE SEQUENCING, AND EXPRESSION OF TETANUS TOXIN FRAGMENT-C IN ESCHERICHIA-COLI, JOURNAL OF BACTERIOLOGY, Vol: 165, Pages: 21-27, ISSN: 0021-9193
DOUGAN G, FAIRWEATHER N, 1985, GENETIC-ANALYSIS OF GRAM-POSITIVE TOXIN DETERMINANTS - THE IMPACT OF NEW TECHNOLOGIES, MICROBIOLOGICAL SCIENCES, Vol: 2, Pages: 144-147, ISSN: 0265-1351
HERRERO E, FAIRWEATHER NF, HOLLAND IB, 1982, ENVELOPE PROTEIN-SYNTHESIS AND INHIBITION OF CELL-DIVISION IN ESCHERICHIA-COLI DURING INACTIVATION OF THE B-SUBUNIT OF DNA GYRASE, JOURNAL OF GENERAL MICROBIOLOGY, Vol: 128, Pages: 361-369, ISSN: 0022-1287
Fairweather NF, Orr E, Holland IB, 1980, Inhibition of deoxyribonucleic acid gyrase: effects on nucleic acid synthesis and cell division in Escherichia coli K-12., J Bacteriol, Vol: 142, Pages: 153-161, ISSN: 0021-9193
Mutants of Escherichia coli resistant to the antibiotic clorobiocin are also coumermycin resistant, and the mutation to resistance in at least one mutant was mapped near gyrB. We conclude, therefore, that clorobiocin inhibits deoxyribonucleic acid gyrase, and the drug was used to probe the role of this enzyme in vivo. Deozyribonucleic acid synthesis was preferentially inhibited but not completely blocked by the antibiotic. Transcription and cell division were also markedly affected. However, unlike other inhibitors of deoxyribonucleic acid synthesis, clorobiocin failed to induce the synthesis of protein X, the recA gene product. In mutants resistant to clorobiocin the replication velocity was unaffected, but initiation of deoxyribonucleic acid synthesis appeared to be delayed. We conclude that deoxyribonucleic acid gyrase, and hence the supercoiled structure of the chromosome, is important for transcription, normal initiation of deoxyribonucleic acid replication, and cell division. The possible role of deoxyribonucleic acid gyrase in the elongation of replication forks is also discussed.
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