Young Investigator at Imperial College London, Bennett Fellow of Bloodwise
Dr Niklas Feldhahn received his PhD in 2006 at the University of Düsseldorf in Germany under the supervision of Professor Markus Müschen. His research during his PhD focused on oncogenic signaling in B-lymphoid leukaemia. After his PhD, Dr Feldhahn joined the laboratory of Professor Nora Heisterkamp at the Children's Hospital Los Angeles, to study mechanisms of drug-resistance to small-molecule inhibitors. In 2008, he joined the laboratory of Professor Michel Nussenzweig at the Rockefeller University New York as a senior postdoctoral research fellow. At the Rockefeller University, he generated in vivo models for DNA damage response genes to study their function, and analyzed DNA damage and genomic instability in normal and malignant B-cells using next-generation sequencing-based methods.
Niklas Feldhahn is currently an Early Career Research fellow of the Department of Medicine at Imperial College London and a Bennett Fellow of Bloodwise. His main research interests are the analysis of DNA damage events involved in the induction and progresssion of leukemia, and mechanisms that protect genome integrity in general. His research is supported by Bloodwise, Leuka, the european commission (EC) and Action against cancer (AAC).
et al., 2017, Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors, Cell Reports, Vol:18, ISSN:2211-1247, Pages:1687-1698
et al., 2015, Mutations in SNRPB, Encoding Components of the Core Splicing Machinery, Cause Cerebro-Costo-Mandibular Syndrome, Human Mutation, Vol:36, ISSN:1059-7794, Pages:187-190
et al., 2015, Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma, Cell, Vol:162, ISSN:0092-8674, Pages:727-737
et al., 2013, Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching, Science, Vol:339, ISSN:0036-8075, Pages:711-715
et al., 2013, 53BP1 Alters the Landscape of DNA Rearrangements and Suppresses AID-Induced B Cell Lymphoma, Molecular Cell, Vol:49, ISSN:1097-2765, Pages:623-631