My central research interest is in understanding how general anaesthetics act. I have worked on this problem mainly at the molecular and cellular levels but more recently I have become interested in how anaesthetics act at the level of neuronal networks and have been pursuing the possibility that the sedative and hypnotic actions of general anaesthetics may be mediated through the same neuronal pathways that control natural sleep. I work closely with Bill Wisden and Stephen Brickley.
Current Group members
PREVIOUS GROUP MEMBERS
et al., 2019, Noble gas neuroprotection: Xenon and argon protect against hypoxic-ischaemic injury in rat hippocampus in vitro via distinct mechanisms, British Journal of Anaesthesia, ISSN:1471-6771
et al., 2019, Corrigendum: Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness., Sleep, Vol:42
et al., Galanin neurons unite sleep homeostasis and alpha2 adrenergic sedation, Current Biology, ISSN:1879-0445
et al., 2019, Xenon prevents early neuronal loss and neuroinflammation in a rat model of traumatic brain injury, BJA Research Forum / Anaesthetic Research Society, Elsevier, Pages:e508-e509, ISSN:0007-0912
et al., 2019, XENON PREVENTS NEURODEGENERATION AND LATE-ONSET COGNITIVE IMPAIRMENT, AND IMPROVES SURVIVAL AFTER TRAUMATIC BRAIN INJURY IN MICE, 37th Annual National Neurotrauma Symposium, MARY ANN LIEBERT, INC, Pages:A47-A47, ISSN:0897-7151