My central research interest is in understanding how general anaesthetics act. I have worked on this problem mainly at the molecular and cellular levels but more recently I have become interested in how anaesthetics act at the level of neuronal networks and have been pursuing the possibility that the sedative and hypnotic actions of general anaesthetics may be mediated through the same neuronal pathways that control natural sleep. I work closely with Bill Wisden and Stephen Brickley.
Current Group members
Wisden W, Yu X, Franks NP, 2017, GABA Receptors and the Pharmacology of Sleep., Handb Exp Pharmacol, ISSN:0171-2004
et al., 2017, Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAA Receptors with Different γ Subunits., Front Cell Neurosci, Vol:11, ISSN:1662-5102
et al., 2016, Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial, Lancet Neurology, Vol:15, ISSN:1474-4422, Pages:145-153
et al., 2016, Activation and modulation of recombinant glycine and GABA(A) receptors by 4-halogenated analogues of propofol, British Journal of Pharmacology, Vol:173, ISSN:0007-1188, Pages:3110-3120
et al., 2016, THE NOBLE GAS XENON REDUCES SECONDARY INJURYAND IMPROVES LONG-TERM LOCOMOTOR FUNCTION AFTER TRAUMATIC BRAIN INJURY IN RODENTS, 27th International Symposium on Cerebral Blood Flow, Metabolism and Function / 12th International Conference on Quantification of Brain Function with PET, SAGE PUBLICATIONS INC, Pages:308-309, ISSN:0271-678X