Imperial College London

Professor Nick Franks, FRS

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Biophysics and Anaesthetics



+44 (0)20 7594 7629n.franks Website




401ASir Ernst Chain BuildingSouth Kensington Campus





My central research interest is in understanding how general anaesthetics act. I have worked on this problem mainly at the molecular and cellular levels but more recently I have become interested in how anaesthetics act at the level of neuronal networks and have been pursuing the possibility that the sedative and hypnotic actions of general anaesthetics may be mediated through the same neuronal pathways that control natural sleep. I work closely with Bill Wisden and Stephen Brickley.

My publications from Google Scholar

My profile from ORCID

Current Group members

Nick and BillWei and RaquelKyoko and GiuliaYing and LedaBerta and DavidEd and ChrisEd and XiaoBryan and Mathieu



Lily, Alessandro and Chris

Rowan,Valentina,FabiaCigdem, Ed and Rowan



Harding E, Franks N, Wisden W, The Temperature Dependence of Sleep, Frontiers in Neuroscience, ISSN:1662-4548

Campos-Pires R, Hirnet T, Valeo F, et al., Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice, British Journal of Anaesthesia, ISSN:1471-6771

Yu X, Ma Y, Harding EC, et al., 2019, Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness., Sleep

Scammell TE, Jackson AC, Franks NP, et al., 2019, Histamine: neural circuits and new medications, Sleep, Vol:42, ISSN:1550-9109

Yu X, Li W, Ma Y, et al., 2019, GABA and glutamate neurons in the VTA regulate sleep and wakefulness, Nature Neuroscience, Vol:22, ISSN:1097-6256, Pages:106-+

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