My central research interest is in understanding how general anaesthetics act. I have worked on this problem mainly at the molecular and cellular levels but more recently I have become interested in how anaesthetics act at the level of neuronal networks and have been pursuing the possibility that the sedative and hypnotic actions of general anaesthetics may be mediated through the same neuronal pathways that control natural sleep.
My laboratory is merged with that of Bill Wisden and our joint website can be found here: franks-wisden-lab.
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et al., 2020, Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study, Critical Care (uk), Vol:24, ISSN:1364-8535, Pages:1-18
et al., 2020, Sleep deprivation triggers somatostatin neurons in prefrontal cortex to initiate nesting and sleep via the preoptic and lateral hypothalamus
et al., 2020, Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior., Molecular Psychiatry, ISSN:1359-4184
et al., 2020, Does sleep deprivation cause stress in mice? A comparison of gentle handling versus novel object presentation sleep deprivation methods, 25th Congress of the European-Sleep-Research-Society (ESRS), WILEY, Pages:195-196, ISSN:0962-1105