My central research interest is in understanding how general anaesthetics act. I have worked on this problem mainly at the molecular and cellular levels but more recently I have become interested in how anaesthetics act at the level of neuronal networks and have been pursuing the possibility that the sedative and hypnotic actions of general anaesthetics may be mediated through the same neuronal pathways that control natural sleep. I work closely with Bill Wisden and Stephen Brickley.
Current Group members
et al., 2019, GABA and glutamate neurons in the VTA regulate sleep and wakefulness, Nature Neuroscience, Vol:22, ISSN:1097-6256, Pages:106-+
et al., 2018, Histamine: Neural circuits and new medications., Sleep
et al., 2018, nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta, Eneuro, Vol:5, ISSN:2373-2822
et al., 2018, A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus, Current Biology, Vol:28, ISSN:0960-9822, Pages:2263-+
et al., 2018, Xenon Protects against Blast-Induced Traumatic Brain Injury in an In Vitro Model, Journal of Neurotrauma, Vol:35, ISSN:0897-7151, Pages:1037-1044