My central research interest is in understanding how general anaesthetics act. I have worked on this problem mainly at the molecular and cellular levels but more recently I have become interested in how anaesthetics act at the level of neuronal networks and have been pursuing the possibility that the sedative and hypnotic actions of general anaesthetics may be mediated through the same neuronal pathways that control natural sleep. I work closely with Bill Wisden and Stephen Brickley.
Current Group members
Brickley SG, Wisden W, Franks NP, Modulation of GABA-A receptor function and sleep, Current Opinion in Physiology, ISSN:2468-8673
et al., A neuronal hub binding sleep initiation and body cooling in response to a warm external stimulus, Current Biology, ISSN:1879-0445
et al., 2018, Xenon Protects against Blast-Induced Traumatic Brain Injury in an In Vitro Model, Journal of Neurotrauma, Vol:35, ISSN:0897-7151, Pages:1037-1044
et al., 2018, Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation, Current Biology, Vol:28, ISSN:0960-9822, Pages:580-+
Yu X, Franks NP, Wisden W, 2018, Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems, Frontiers in Neural Circuits, Vol:12, ISSN:1662-5110