My central research interest is in understanding how general anaesthetics act. I have worked on this problem mainly at the molecular and cellular levels but more recently I have become interested in how anaesthetics act at the level of neuronal networks and have been pursuing the possibility that the sedative and hypnotic actions of general anaesthetics may be mediated through the same neuronal pathways that control natural sleep. I work closely with Bill Wisden and Stephen Brickley.
Current Group members
PREVIOUS GROUP MEMBERS
Harding E, Franks N, Wisden W, The Temperature Dependence of Sleep, Frontiers in Neuroscience, ISSN:1662-4548
et al., Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice, British Journal of Anaesthesia, ISSN:1471-6771
et al., 2019, Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness., Sleep
et al., 2019, Histamine: neural circuits and new medications, Sleep, Vol:42, ISSN:1550-9109
et al., 2019, GABA and glutamate neurons in the VTA regulate sleep and wakefulness, Nature Neuroscience, Vol:22, ISSN:1097-6256, Pages:106-+