Publications
263 results found
Reshat R, Priestley CC, Gooderham NJ, 2012, A triple-helix forming oligonucleotide targeting genomic DNA fails to induce mutation, MUTAGENESIS, Vol: 27, Pages: 713-719, ISSN: 0267-8357
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- Citations: 3
Koufaris C, Wright J, Currie RA, et al., 2012, Hepatic MicroRNA Profiles Offer Predictive and Mechanistic Insights After Exposure to Genotoxic and Epigenetic Hepatocarcinogens, TOXICOLOGICAL SCIENCES, Vol: 128, Pages: 532-543, ISSN: 1096-6080
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- Citations: 46
Wu Q, Li JV, Seyfried F, et al., 2012, Bariatric surgery profoundly changes circulating MicroRNA profile in the rat, CANCER RESEARCH, Vol: 72, ISSN: 0008-5472
David RM, Gooderham NJ, 2012, Genotoxic consequences of exposure to mixtures of food-derived chemical carcinogens, Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472
Abd Kadir NH, Rossiter JT, Gooderham NJ, 2011, The chemopreventive properties of cruciferous vegetables: Is oxidative stress in cancer cell cytotoxicity induced by glucosinolate hydrolysis products?, TOXICOLOGY, Vol: 290, Pages: 118-119, ISSN: 0300-483X
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- Citations: 2
LI JV, Reshat R, Wu Q, et al., 2011, Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents, Frontiers in Microbiology, Vol: 2, Pages: 1-9
Smith RL, Waddell WJ, Cohen SM, et al., 2011, GRAS FLAVORING SUBSTANCES 25, Food Technology, Vol: 65, Pages: 44-55, ISSN: 0015-6639
Flavor and Extract Manufacturers Association (FEMA) provides an update on recent progress in the consideration of flavoring ingredients generally recognized as safe (GRAS) under the Food Additives Amendment. The Panel re-evaluated all relevant metabolic and toxicity data for these flavor ingredients within the context of their increased use levels in chewing gum. Pyridine was reaffirmed as GRAS (GRASr) in 2010 based upon its efficient detoxification in humans; its low level of flavor use; the lack of genotoxic and mutagenic potential. The substance 2-hexyl- 4-acetoxytetrahydrofuran was removed from the GRAS list. The FEMA Expert Panel concludes that the neutral, hydrated, and salt forms of GRAS substances that are physiologically equivalent are assigned the same GRAS number. The same GRAS number would also be applied to the sodium, potassium, calcium, ferrous, ferric, ammonium, and quaternary ammonium salts derived from FEMA GRAS amines, carboxylates, sulfonates, sulfamates, or sulfates.
Koufaris C, Wright J, Currie RA, et al., 2011, A characteristic set of microRNAs are deregulated in pre-neoplastic liver exposed to chemical carcinogens, Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472
David RM, Patel S, Kadir NHA, et al., 2011, Cruciferous vegetable glucosinolate hydrolysis products protect against Benzo[a]pyrene-induced genotoxicity, CANCER RESEARCH, Vol: 71, ISSN: 0008-5472
Lauber SN, Gooderham NJ, 2011, The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells, TOXICOLOGY, Vol: 279, Pages: 139-145, ISSN: 0300-483X
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- Citations: 18
Ashrafian H, Ahmed K, Rowland S, et al., 2011, Metabolic surgery and cancer: The protective effects of bariatric procedures., Cancer, Vol: 117, Pages: 1788-1799, ISSN: 0008-543X
The worldwide epidemic of obesity and the global incidence of cancer are both increasing. There is now epidemiological evidence to support a correlation between obesity, weight gain, and some cancers. Metabolic or bariatric surgery can provide sustained weight loss and reduced obesity-related mortality. These procedures can also improve the metabolic profile to decrease cardiovascular risk and resolve diabetes in morbidly obese patients. The operations offer several physiological steps, the so-called BRAVE effects: 1) bile flow alteration, 2) reduction of gastric size, 3) anatomical gut rearrangement and altered flow of nutrients, 4) vagal manipulation and 5) enteric gut hormone modulation. Metabolic operations are also associated with a significant reduction of cancer incidence and mortality. The cancer-protective role of metabolic surgery is strongest for female obesity-related tumors; however, the underlying mechanisms may involve both weight-dependent and weight-independent effects. These include the improvement of insulin resistance with attenuation of the metabolic syndrome as well as decreased oxidative stress and inflammation in addition to the beneficial modulation of sex steroids, gut hormones, cellular energetics, immune system, and adipokines. Elucidating the precise metabolic mechanisms of cancer prevention by metabolic surgery can increase our understanding of how obesity, diabetes, and metabolic syndrome are associated with cancer. It may also offer novel treatment strategies in the management of tumor generation and growth.
Edmands WMB, Beckonert OP, Stella C, et al., 2011, Identification of Human Urinary Biomarkers of Cruciferous Vegetable Consumption by Metabonomic Profiling., J Proteome Res., Vol: 10, Pages: 4513-4521
Koufaris C, Wright J, Currie R, et al., 2010, The non-genotoxic hepatocarcinogen Phenobarbital causes persistent changes in the expression of liver microRNAs in the male Fischer rat, 2010 Annual Spring Meeting of the British-Toxicological-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 354-354, ISSN: 0300-483X
Abd Kadir NH, Rossiter JT, Gooderham NJ, 2010, In vitro toxicity study of synthetic and natural alkenyl glucosinolate hydrolysis products on cHo1 and MCL5 cell lines, TOXICOLOGY LETTERS, Vol: 196, Pages: S150-S150, ISSN: 0378-4274
Gu D, McNaughton L, Le Master D, et al., 2010, A comprehensive approach to profile the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and their metabolites in urine of meat eaters., Chem. Res. Toxicol., Vol: 23, Pages: 788-801
Saidin NA, Holmes E, Randall T, et al., 2010, Extract of Malaysian Kratom and its major alkaloid, mitragynine: Is their cytotoxicity mediated by opioid receptors?
Riches LC, Lynch AM, Gooderham NJ, 2010, A molecular beacon approach to detecting RAD52 expression in response to DNA damage in human cells., Toxicol in vitro, Vol: 24, Pages: 652-660
Edmands WM, Geier F, Benton P, et al., 2009, Analysis of the effects of cruciferous vegetable consumption on human metabolic phenotype analysed by UPLC-mass spectrometry, Annual Congress of the British-Toxicological-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 11-11, ISSN: 0300-483X
Kadir NHA, Rossiter JT, Gooderham NJ, 2009, <i>In vitro</i> toxicology of 2-propenyl and 3-butenyl glucosinolate derivatives, Annual Congress of the British-Toxicological-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 15-16, ISSN: 0300-483X
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- Citations: 1
Edmands WM, Holmes E, Gooderham NJ, 2009, Effect of a Red Meat Meal on Human Urinary Metabotype After Cruciferous Vegetable Consumption, Annual Congress of the British-Toxicological-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 2-2, ISSN: 0300-483X
Koufaris C, Wright J, Currie R, et al., 2009, Carcinogenic and non-carcinogenic doses of Phenobarbital cause distinct microrna profiles in male Fischer rats after 14 days of dietary exposure, Annual Congress of the British-Toxicological-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 16-17, ISSN: 0300-483X
Charalambous MP, Lightfoot T, Speirs V, et al., 2009, Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue, BRITISH JOURNAL OF CANCER, Vol: 101, Pages: 106-115, ISSN: 0007-0920
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- Citations: 68
Fede J-M, Thakur AP, Gooderham NJ, et al., 2009, Biomonitoring of 2-Amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine (PhIP) and Its Carcinogenic Metabolites in Urine, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 22, Pages: 1096-1105, ISSN: 0893-228X
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- Citations: 22
Koufaris C, Wright J, Currie R, et al., 2009, Dose and temporal dependent deregulation of liver microRNAs by the non-genotoxic hepatocarcinogen phenobarbital in male Fischer rats, Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472
Ansah C, Gooderham NJ, 2009, Cryptolepine provokes changes in the expression of cell cycle proteins in growing cells, Amer. J. Pharmacol. and Toxicol., Vol: 4
Saidin N-A, Randall T, Takayama H, et al., 2008, Malaysian <i>Kratom</i>, a phyto-pharmaceutical of abuse: Studies on the mechanism of its cytotoxicity, Annual Congress of the British-Toxicological-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 19-20, ISSN: 0300-483X
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- Citations: 13
Riches LC, Lynch AM, Gooderham NJ, 2008, Early events in the mammalian response to DNA double-strand breaks, MUTAGENESIS, Vol: 23, Pages: 331-339, ISSN: 0267-8357
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- Citations: 97
Saidin NA, Takayama H, Holmes E, et al., 2008, Cytotoxicity of extract of Malaysian <i>Kratom</i> and its dominant alkaloid mitragynine, on human cell lines, 7th Annual Oxford International Conference on the Science of Botanicals/4th Interim Meeting of the American-Society-of-Pharmacognosy, Publisher: GEORG THIEME VERLAG KG, Pages: 348-348, ISSN: 0032-0943
Ansah C, Zhu H, Gooderham NJ, 2008, The mechanism of cryptolepine-induced cell death.” J Pharmacol & Toxicol., 3, (2008), 291-301., Journal of Pharmacology and Toxicology, Vol: 3, Pages: 291-301
Creton SK, Zhu H, Gooderham NJ, 2007, The cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates ERK-MAP kinase pathway., Cancer Research, Vol: 67
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