Publications
263 results found
Saidin NA, Gooderham NJ, 2007, <i>In vitro</i> toxicology of extract of <i>Mitragyna speciosa</i> Korth, a Malaysian phyto-pharmaceutical of abuse, Annual Congress of the British-Toxicological-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 166-167, ISSN: 0300-483X
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- Citations: 7
Riches LC, Lynch AM, Gooderham NJ, 2007, Molecular beacon to detect transcription of RAD52 in response to DNA double strand breaks, Annual Congress of the British-Toxicological-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 176-177, ISSN: 0300-483X
Riches LC, Lynch AM, Gooderham NJ, 2007, A molecular beacon to detect DNA double strand breaks in human cells: RAD52 mRNA up-regulation is independent of p53 status, MUTAGENESIS, Vol: 22, Pages: 449-449, ISSN: 0267-8357
Lauber SN, Gooderharn NJ, 2007, The cooked meat-derived genotoxic carcinogen 2-Amino-3-Methylimidazo[4,5-<i>b</i>]Pyridine has potent hormone-like activity:: Mechanistic support for a role in breast cancer, CANCER RESEARCH, Vol: 67, Pages: 9597-9602, ISSN: 0008-5472
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- Citations: 27
Gooderham NJ, Creton S, Lauber SN, et al., 2007, Mechanisms of action of the carcinogenic heterocyclic amine PhIP, TOXICOLOGY LETTERS, Vol: 168, Pages: 269-277, ISSN: 0378-4274
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- Citations: 36
Alison MR, Gooderham NJ, 2007, The Cancer Handbook, London, Publisher: John Wiley and Sons, ISBN: 978-0-470-01852-1
Gooderham NJ, Carmichael PL, 2007, Mechanisms of Chemical Carcinogenesis, The Cancer Handbook, Editors: Alison, Gooderham, Hall, Weiss, Haier, Lemoine, Tempero, London, Publisher: John Wiley and Sons, Pages: 322-337, ISBN: 978-0-470-01852-1
Riches LC, Lynch AM, Gooderham NJ, 2006, Novel methods for detecting double DNA strand breaks, TOXICOLOGY LETTERS, Vol: 164, Pages: S263-S263, ISSN: 0378-4274
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- Citations: 1
Gooderham NJ, Lauber SN, Creton SK, et al., 2006, Mechanisms of action of carcinogenic heterocyclic amines, TOXICOLOGY LETTERS, Vol: 164, Pages: S61-S62, ISSN: 0378-4274
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- Citations: 1
Zhu H, Gooderharn NJ, 2006, Induction of cell cycle progression by cryptolepine in human lung adenocarcinorna A549 cells, Joint Congress of the British-Toxicology-Society/29th Annual Meeting of the United-Kingdom-Environmental-Mutagen-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 66-67, ISSN: 0300-483X
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- Citations: 1
Riches LC, Lynch AM, Gooderham NJ, 2006, A molecular beacon approach for detecting DNA double strand breaks, Joint Congress of the British-Toxicology-Society/29th Annual Meeting of the United-Kingdom-Environmental-Mutagen-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 61-62, ISSN: 0300-483X
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- Citations: 2
Ellis JK, Carmichael PL, Gooderham NJ, 2006, DNA adduct levels in the liver of the F344 rat treated with the natural flavour methyl eugenol, Joint Congress of the British-Toxicology-Society/29th Annual Meeting of the United-Kingdom-Environmental-Mutagen-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 75-76, ISSN: 0300-483X
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- Citations: 6
Ellis JK, Carmichael PL, Gooderham NJ, 2006, DNA adduct levels in the liver of the F344 rat treated with the natural flavour methyl eugenol, Publisher: OXFORD UNIV PRESS, Pages: 291-292, ISSN: 0267-8357
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- Citations: 2
Zhu HJ, Gooderham NJ, 2006, Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma A549 cells, TOXICOLOGICAL SCIENCES, Vol: 91, Pages: 132-139, ISSN: 1096-6080
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- Citations: 35
Smith CC, Aylott MC, Fisher KJ, et al., 2006, DNA damage responses after exposure to DNA-based products, JOURNAL OF GENE MEDICINE, Vol: 8, Pages: 175-185, ISSN: 1099-498X
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- Citations: 11
McGreavey LE, Turner F, Smith G, et al., 2005, No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARδ and PPARγ act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma, PHARMACOGENETICS AND GENOMICS, Vol: 15, Pages: 713-721, ISSN: 1744-6872
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- Citations: 47
Zhu H, Smith C, Ansah C, et al., 2005, Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells, Cancer Cell International, Vol: 5, Pages: 1-13, ISSN: 1475-2867
BackgroundMany anticancer agents and carcinogens are DNA damaging chemicals and exposure to such chemicals results in the deregulation of cell cycle progression. The molecular mechanisms of DNA damage-induced cell cycle alteration are not well understood. We have studied the effects of etoposide (an anticancer agent), cryptolepine (CLP, a cytotoxic alkaloid), benzo [a]pyrene (BaP, a carcinogenic polycyclic aromatic hydrocarbon) and 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP, a cooked-meat derived carcinogen) on the expression of cell cycle regulatory genes to understand the molecular mechanisms of the cell cycle disturbance.ResultsA549 cells were treated with DMSO or chemicals for up to 72 h and periodically sampled for cell cycle analysis, mRNA and protein expression. DMSO treated cells showed a dominant G1 peak in cell cycle at all times examined. Etoposide and CLP both induced G2/M phase arrest yet the former altered the expression of genes functioning at multiple phases, whilst the latter was more effective in inhibiting the expression of genes in G2-M transition. Both etoposide and CLP induced an accumulation of p53 protein and upregulation of p53 transcriptional target genes. Neither BaP nor PhIP had substantial phase-specific cell cycle effect, however, they induced distinctive changes in gene expression. BaP upregulated the expression of CYP1B1 at 6–24 h and downregulated many cell cycle regulatory genes at 48–72 h. By contrast, PhIP increased the expression of many cell cycle regulatory genes. Changes in the expression of key mRNAs were confirmed at protein level.ConclusionOur experiments show that DNA damaging agents with different mechanisms of action induced distinctive changes in the expression pattern of a panel of cell cycle regulatory genes. We suggest that examining the genomic response to chemical exposure provides an exceptional opportunity to understand the molecular mechanism involved in cellular response to toxicants.
Creton S, Zhu H, Gooderham NJ, 2005, A mechanistic basis for the role of cycle arrest in the genetic toxicology of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine (PhIP), TOXICOLOGICAL SCIENCES, Vol: 84, Pages: 335-343, ISSN: 1096-6080
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- Citations: 14
Ansah C, Khan A, Gooderham NJ, 2005, In vitro genotoxicity of the West African anti-malarial herbal <i>Cryptolepis sanguinolenta</i> and its major alkaloid cryptolepine, TOXICOLOGY, Vol: 208, Pages: 141-147, ISSN: 0300-483X
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- Citations: 46
Holland RD, Gehring T, Taylor J, et al., 2005, Formation of a mutagenic heterocyclic aromatic amine from creatinine in urine of meat eaters and vegetarians, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 18, Pages: 579-590, ISSN: 0893-228X
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- Citations: 14
Ansah C, Gooderham NJ, 2005, Reactive oxygen species is associated with cryptolepine cytotoxicity., Journal of Science and Technology, Vol: 25, Pages: 1-10, ISSN: 0855-0395
Gooderham NJ, 2004, Diet and cancer: variability and susceptibility. Can we learn anything from the heterocyclic amines?, MUTAGENESIS, Vol: 19, Pages: 504-505, ISSN: 0267-8357
Ansah C, Gooderham NJ, 2004, The cell cycle effects of the cytotoxic anti-malarial alkaloid cryptolepine is p53-dependent, 25th Annual Meeting of the British-Toxicology-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 67-67, ISSN: 0300-483X
Walters DG, Young PJ, Agus C, et al., 2004, Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine (PhIP) in humans, CARCINOGENESIS, Vol: 25, Pages: 1659-1669, ISSN: 0143-3334
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- Citations: 72
Holland RD, Taylor J, Schoenbachler L, et al., 2004, Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 17, Pages: 1121-1136, ISSN: 0893-228X
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- Citations: 42
Boyce A, Doehmer J, Gooderham NJ, 2004, Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine and 2-amino-3,8-dimethylimidazo[4,5-<i>f</i>]quinoxaline, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Vol: 802, Pages: 217-223, ISSN: 1570-0232
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- Citations: 17
Ansah C, Gooderham NJ, 2004, Cryptolepine induces G1 arrest and cytotoxicity in human hepatoma HepG2 cells, Annual Congress of the British-Toxicology-Society, Publisher: ELSEVIER SCI IRELAND LTD, Pages: 229-230, ISSN: 0300-483X
Smith CC, Lynch AM, Gooderham NJ, 2004, Differential gene expression of DNA repair genes in response to DNA damaging agents, Annual Congress of the British-Toxicology-Society, Publisher: ELSEVIER SCI IRELAND LTD, Pages: 262-263, ISSN: 0300-483X
Creton S, Gooderham NJ, 2004, Activation of DNA damage response proteins in human breast epithelial cells treated with the cooked meat mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine (PhIP), Annual Congress of the British-Toxicology-Society, Publisher: ELSEVIER SCI IRELAND LTD, Pages: 251-252, ISSN: 0300-483X
SN Lauber, S Ali, NJ Gooderham, 2004, The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity., Carcinogenesis, Vol: 25, Pages: 2509-2517
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