Publications
263 results found
Charalambous MP, Maihöfner C, Bhambra U, et al., 2003, Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells, BRITISH JOURNAL OF CANCER, Vol: 88, Pages: 1598-1604, ISSN: 0007-0920
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- Citations: 66
Smith CC, Lynch AM, Gooderham NJ, 2003, Evaluating the genetic toxicology of DNA-based products using existing genetic toxicology assays, MUTAGENESIS, Vol: 18, Pages: 259-264, ISSN: 0267-8357
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- Citations: 5
Maihöfner C, Charalambous MP, Bhambra U, et al., 2003, Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer, CARCINOGENESIS, Vol: 24, Pages: 665-671, ISSN: 0143-3334
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- Citations: 92
Barrett JH, Smith G, Waxman R, et al., 2003, Investigation of interaction between <i>N</i>-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer, CARCINOGENESIS, Vol: 24, Pages: 275-282, ISSN: 0143-3334
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- Citations: 83
Sachse C, Bhambra U, Smith G, et al., 2003, Polymorphisms in the cytochrome P450 CYP1A2 gene (<i>CYP1A2</i>) in colorectal cancer patients and controls:: allele frequencies, linkage disequilibrium and influence on caffeine metabolism, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 55, Pages: 68-76, ISSN: 0306-5251
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- Citations: 139
Ansah C, Gooderham NJ, 2002, The popular herbal antimalarial, extract of <i>Cryptolepis sanguinolenta</i>, is potently cytotoxic, TOXICOLOGICAL SCIENCES, Vol: 70, Pages: 245-251, ISSN: 1096-6080
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- Citations: 52
Sachse C, Smith G, Wilkie MJV, et al., 2002, A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer, CARCINOGENESIS, Vol: 23, Pages: 1839-1849, ISSN: 0143-3334
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- Citations: 240
Gooderham NJ, Zhu H, Lauber S, et al., 2002, Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine (PhIP), MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 506, Pages: 91-99, ISSN: 0027-5107
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- Citations: 60
Zhu HJ, Gooderham N, 2002, Neoplastic transformation of human lung fibroblast MRC-5 SV2 cells induced by benzo[<i>a</i>]pyrene and confluence culture, CANCER RESEARCH, Vol: 62, Pages: 4605-4609, ISSN: 0008-5472
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- Citations: 23
Gooderham NJ, 2002, The Cancer Handbook, Publisher: Nature Publishing Group, London, New York & Tokyo, ISBN: 9780333776599
Charalambous M, Maihoejner C, Bhambra U, et al., 2001, Expression of NFκB and COX-2 in human colorectal cancer, Publisher: ELSEVIER SCI IRELAND LTD, Pages: 88-89, ISSN: 0300-483X
Bhambra U, Edwards R, Lightfoot T, et al., 2001, Heterocyclic amines and human colon cancer: Identification of risk factors, TOXICOLOGY, Vol: 168, Pages: 84-86, ISSN: 0300-483X
Lauber S, Ali S, Gooderham NJ, 2001, Does the estrogenicity of the heterocyclic amine PhIP contribute to its genetic toxicology?, TOXICOLOGY, Vol: 168, Pages: 92-94, ISSN: 0300-483X
Murray S, Lake BG, Gray S, et al., 2001, Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man, CARCINOGENESIS, Vol: 22, Pages: 1413-1420, ISSN: 0143-3334
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- Citations: 81
Zhu HJ, Gooderham N, 2001, P450 1A1 dependent and independent effects of benzo[<i>a</i>]pyrene on human lung fibroblast MRC-5V2 cells, TOXICOLOGY, Vol: 164, Pages: 155-155, ISSN: 0300-483X
Gooderham NJ, Murray S, Lynch AM, et al., 2001, Food-derived heterocyclic amine mutagens: Variable metabolism and significance to humans, DRUG METABOLISM AND DISPOSITION, Vol: 29, Pages: 529-534, ISSN: 0090-9556
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- Citations: 49
Gooderham NJ, Carmichael PL, 2001, Mechanisms of Chemical Carcinogenesis, The Cancer Handbook, Publisher: Nature Publishing Group, Pages: 273-291, ISBN: 9780333776599
Crosbie SJ, Murray S, Boobis AR, et al., 2000, Mass spectrometric detection and measurement of <i>N</i><SUP>2</SUP>-(2′-deoxyguanosin-8-yl)PhIP adducts in DNA, JOURNAL OF CHROMATOGRAPHY B, Vol: 744, Pages: 55-64, ISSN: 0378-4347
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- Citations: 22
Zhu HJ, Boobis AR, Gooderham NJ, 2000, The food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine activates S-Phase checkpoint and apoptosis, and induces gene mutation in human lymphoblastoid TK6 cells, CANCER RESEARCH, Vol: 60, Pages: 1283-1289, ISSN: 0008-5472
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- Citations: 28
Watson K, Gooderham NJ, Davies DS, et al., 1999, Nucleosomes bind to cell surface proteoglycans, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 274, Pages: 21707-21713, ISSN: 0021-9258
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- Citations: 75
Watson K, Gooderham NJ, Davies DS, et al., 1999, Interaction of the transactivating protein HIV-1 tat with sulphated polysaccharides, BIOCHEMICAL PHARMACOLOGY, Vol: 57, Pages: 775-783, ISSN: 0006-2952
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- Citations: 43
Brooks RA, Gooderham NJ, Edwards RJ, et al., 1999, The mutagenicity of benzo[<i>a</i>]pyrene in mouse small intestine, CARCINOGENESIS, Vol: 20, Pages: 109-114, ISSN: 0143-3334
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- Citations: 29
Lynch AM, Gooderham NJ, Davies DS, et al., 1998, Genetic analysis of PHIP intestinal mutations in Muta™Mouse, MUTAGENESIS, Vol: 13, Pages: 601-605, ISSN: 0267-8357
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- Citations: 35
Lynch AM, Gooderham NJ, Davies DS, et al., 1998, Food-derived heterocyclic amines induce a spectrum of mutations which are diagnostic of their mutagenicity, ISSN: 0267-8357
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- Citations: 1
Lewis DFV, 1998, Molecular modelling in drug metabolism: The cytochromes P450, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 1-12, ISSN: 0929-6743
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- Citations: 3
Dollery C, Boobis A, Rawlins M, et al., 1998, Therapeutic Drugs, London, Publisher: Churchill Livingston, ISBN: 9780443051487
Smith DA, 1998, High throughput drug metabolism, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 137-143, ISSN: 0929-6743
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- Citations: 17
Gooderham NJ, 1998, Drug Metabolism: Towards the next Millennium, Holland, Publisher: IOS Press, ISBN: 9789051993783
Burke MD, 1998, Oxidation at carbon via cytochrome P450 CYP1B1, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 24-29, ISSN: 0929-6743
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- Citations: 1
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