Publications
263 results found
Coughtrie MWH, Dajani R, Kauffman FC, et al., 1998, Sulfotransferases and the biology of sulfation, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 89-100, ISSN: 0929-6743
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- Citations: 3
Cowan DA, Laidler P, 1998, Mass spectrometry in drug metabolism, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 159-174, ISSN: 0929-6743
Gooderham NJ, Lynch AM, Yadollahi-Farsani M, et al., 1998, Metabolism and genotoxicity of food-derived heterocyclic amines, Drug Metabolism: Towards the next Millennium, Editors: Gooderham, Amsterdam, Publisher: IOS Press, Pages: 127-136
Sandler M, 1998, The role of amine oxidases in xenobiotic metabolism, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 53-58, ISSN: 0929-6743
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- Citations: 8
Beedham C, 1998, Oxidation of carbon via molybdenum hydroxylases, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 39-52, ISSN: 0929-6743
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- Citations: 11
Campbell B, 1998, The use of kinetic and metabolic predictions in drug development, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 144-158, ISSN: 0929-6743
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- Citations: 3
Tucker GT, 1998, Clinical aspects of polymorphic drug metabolism, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 109-118, ISSN: 0929-6743
Patterson LH, Raleigh SM, 1998, Reductive metabolism: its application in prodrug activation, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 72-79, ISSN: 0929-6743
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- Citations: 10
Gibson GG, 1998, Recombinant DNA methods in drug metabolism and toxicology, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 13-23, ISSN: 0929-6743
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- Citations: 1
Cupid BC, Garner RC, 1998, Accelerator mass spectrometry - A new tool for drug metabolism studies, Symposium on Drug Metabolism - Towards the Next Millennium, Publisher: I O S PRESS, Pages: 175-187, ISSN: 0929-6743
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- Citations: 5
Javan CM, Gooderham NJ, Edwards RJ, et al., 1997, Anti-HIV type 1 activity of sulfated derivatives of dextrin against primary viral isolates of HIV type 1 in lymphocytes and monocyte-derived macrophages, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 13, Pages: 875-880, ISSN: 0889-2229
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- Citations: 32
Gooderham NJ, Murray S, Lynch AM, et al., 1997, Assessing human risk to heterocyclic amines, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 376, Pages: 53-60, ISSN: 0027-5107
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- Citations: 37
Crosbie SJ, Boobis AR, Gooderham NJ, 1997, Analysis of the N-(deoxyguanosin-8-yl) adduct of the food derived carcinogen PhIP using capillary electrophoresis., Biochem Soc Trans, Vol: 25, ISSN: 0300-5127
Gooderham NJ, 1997, The metabolism of heterocyclic amines., ECP News, Vol: 31, Pages: 24-27
Lynch AM, Gooderham NJ, Boobis AR, 1996, Organ distinctive mutagenicity in muta(TM)mouse after short-term exposure to PhIP, MUTAGENESIS, Vol: 11, Pages: 505-509, ISSN: 0267-8357
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- Citations: 21
Gooderham NJ, Murray S, Lynch AM, et al., 1996, Heterocyclic amines: Evaluation of their role in diet associated human cancer, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 42, Pages: 91-98, ISSN: 0306-5251
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- Citations: 37
YadollahiFarsani M, Gooderham NJ, Davies DS, et al., 1996, Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus, CARCINOGENESIS, Vol: 17, Pages: 617-624, ISSN: 0143-3334
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- Citations: 70
Rich KJ, Zhao K, Davies DS, et al., 1996, Developmental changes in hepatic activation of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline in rabbit, CARCINOGENESIS, Vol: 17, Pages: 555-558, ISSN: 0143-3334
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- Citations: 4
Boobis AR, Gooderham NJ, Edwards RJ, et al., 1996, Enzymic and interindividual differences in the human metabolism of heterocyclic amines, TOXICOLOGY - FROM CELLS TO MAN, Vol: 18, Pages: 286-302
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- Citations: 20
Davies DS, Gooderham NJ, Murray S, et al., 1996, Chemical methods for assessing systemic exposure to dietary heterocyclic amines in man, TOXICOLOGY - FROM CELLS TO MAN, Vol: 18, Pages: 251-258
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- Citations: 3
Lynch AM, Murray S, Gooderham NJ, et al., 1995, Exposure to and activation of dietary heterocyclic amines in humans, CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, Vol: 21, Pages: 19-31, ISSN: 1040-8428
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- Citations: 19
WATSON K, EDWARDS RJ, SHAUNAK S, et al., 1995, EXTRA-NUCLEAR LOCATION OF HISTONES IN ACTIVATED HUMAN PERIPHERAL-BLOOD LYMPHOCYTES AND CULTURED T-CELLS, BIOCHEMICAL PHARMACOLOGY, Vol: 50, Pages: 299-309, ISSN: 0006-2952
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- Citations: 72
Boobis AR, Gooderham NJ, Rich KJ, et al., 1995, Enzymatic studies of the activation of heterocyclic food mutagens in man., Princess Takamatsu Symp, Vol: 23, Pages: 134-144
2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are amongst the most abundant of the heterocyclic aromatic amines formed during the cooking of beef. Both compounds are genotoxic and carcinogenic in rodents. These effects are manifested only after activation of the amines by P450. Human liver is very active at converting these amines to mutagenic products. Studies in vitro have established that, for both amines, mutagenicity with human liver microsomes is entirely via the N-hydroxylamine, essentially the only oxidation product of either amine. Both N-hydroxylation and mutagenicity of the amines can be almost completely inhibited by furafylline, a potent and highly selective inhibitor of CYP1A2 in man. These data, together with the work of others, show that the N-hydroxylation and hence the mutagenicity of both MeIQx and PhIP in man is catalyzed almost exclusively by CYP1A2. Liver from cynomolgus monkeys, unlike that from humans and marmosets, is very poor at activating MeIQx or PhIP to mutagenic products. Studies with anti-peptide antibodies of defined specificity revealed that this is due to the absence of CYP1A2, suggesting that this species should not be used to assess the possible risk posed to man by these amines. The marmoset would be a better species for this purpose.
Davies DS, Gooderham NJ, Murray S, et al., 1995, Systemic exposure to dietary heterocyclic amines in man., Princess Takamatsu Symp, Vol: 23, Pages: 190-196
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-I-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are formed during the cooking of meat and account for a significant proportion of the mutagenic material present in cooked beef. The amines are not directly mutagenic but are converted to active intermediates by P450. Studies in vitro with human liver have shown that N-hydroxylation catalyzed by CYP1A2 is the major pathway of oxidation of MeQx and PhIP and is solely responsible for the generation of mutagenic species. In the studies reported in this paper it is demonstrated that both MelIQx and PhIP are well absorbed and extensively metabolized following ingestion of amine-containing beef by humans. Experiments with furafylline, a potent and selective inhibitor of human CYP1A2, reveal that more than 90% of MeIQx and 70% of PhIP are N-hydroxylated in vivo, probably presystemically in the liver.
SHAUNAK S, GOODERHAM NJ, EDWARDS RJ, et al., 1994, INFECTION BY HIV-1 BLOCKED BY BINDING OF DEXTRIN 2-SULFATE TO THE CELL-SURFACE OF ACTIVATED HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS AND CULTURED T-CELLS, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 113, Pages: 151-158, ISSN: 0007-1188
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- Citations: 38
ZHAO K, MURRAY S, DAVIES DS, et al., 1994, METABOLISM OF THE FOOD-DERIVED MUTAGEN AND CARCINOGEN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE (PHIP) BY HUMAN LIVER-MICROSOMES, CARCINOGENESIS, Vol: 15, Pages: 1285-1288, ISSN: 0143-3334
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- Citations: 81
WATSON K, EDWARDS RJ, PARMELEE DC, et al., 1994, HISTONES LOCATED ON THE PLASMA-MEMBRANE OF T-CELLS, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 22, Pages: S199-S199, ISSN: 0300-5127
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- Citations: 6
ZHAO KC, BOOBIS AR, DAVIES DS, et al., 1994, THE ROLE OF CYP1A ENZYMES IN MURINE ACTIVATION OF THE COOKED FOOD CARCINOGEN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 22, Pages: S128-S128, ISSN: 0300-5127
BROOKS RA, GOODERHAM NJ, ZHAO KC, et al., 1994, 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE IS A POTENT MUTAGEN IN THE MOUSE SMALL-INTESTINE, CANCER RESEARCH, Vol: 54, Pages: 1665-1671, ISSN: 0008-5472
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- Citations: 38
BOOBIS AR, LYNCH AM, MURRAY S, et al., 1994, CYP1A2-CATALYZED CONVERSION OF DIETARY HETEROCYCLIC AMINES TO THEIR PROXIMATE CARCINOGENS IS THEIR MAJOR ROUTE OF METABOLISM IN HUMANS, CANCER RESEARCH, Vol: 54, Pages: 89-94, ISSN: 0008-5472
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- Citations: 260
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