Imperial College London

ProfessorNicholasGrassly

Faculty of MedicineSchool of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3264n.grassly Website

 
 
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Location

 

G36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Parker:2019:infdis/jiy553,
author = {Parker, EPK and Whitfield, H and Baskar, C and Giri, S and John, J and Grassly, N and Kang, G and Praharaj, I},
doi = {infdis/jiy553},
journal = {Journal of Infectious Diseases},
pages = {578--581},
title = {FUT2 secretor status is not associated with oral poliovirus vaccine immunogenicity in south Indian infants},
url = {http://dx.doi.org/10.1093/infdis/jiy553},
volume = {219},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - FUT2 determines whether histo-blood group antigens are secreted at mucosal surfaces. Secretor status influences susceptibility to enteric viruses, potentially including oral poliovirus vaccine (OPV). We performed a nested case–control study to determine the association between FUT2 genotype (single-nucleotide polymorphisms G428A, C302T, and A385T) and seroconversion among Indian infants who received a single dose of monovalent type 3 OPV. Secretor prevalence was 75% (89 of 118) in infants who seroconverted and 80% (97 of 122) in infants who did not seroconvert (odds ratio, 0.79; 95% confidence interval, .43–1.45). Our findings suggest that FUT2 genotype is not a key determinant of variation in OPV immunogenicity.
AU - Parker,EPK
AU - Whitfield,H
AU - Baskar,C
AU - Giri,S
AU - John,J
AU - Grassly,N
AU - Kang,G
AU - Praharaj,I
DO - infdis/jiy553
EP - 581
PY - 2019///
SN - 0022-1899
SP - 578
TI - FUT2 secretor status is not associated with oral poliovirus vaccine immunogenicity in south Indian infants
T2 - Journal of Infectious Diseases
UR - http://dx.doi.org/10.1093/infdis/jiy553
UR - http://hdl.handle.net/10044/1/64642
VL - 219
ER -