Imperial College London

ProfessorNicholasGrassly

Faculty of MedicineSchool of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3264n.grassly Website

 
 
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Location

 

G36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sarkar:2016:10.1016/j.conctc.2016.12.002,
author = {Sarkar, R and Rose, A and Mohan, VR and Ajjampur, SSR and Veluswamy, V and Srinivasan, R and Muliyil, J and Rajshekhar, V and George, K and Balraj, V and Grassly, NC and Anderson, RM and Brooker, SJ and Kang, G},
doi = {10.1016/j.conctc.2016.12.002},
journal = {Contemporary Clinical Trials Communications},
pages = {49--55},
title = {Study design and baseline results of an open-label cluster randomized community-intervention trial to assess the effectiveness of a modified mass deworming program in reducing hookworm infection in a tribal population in southern India},
url = {http://dx.doi.org/10.1016/j.conctc.2016.12.002},
volume = {5},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Introduction: Hookworm infection is a leading cause of iron deficiency anemia and malnutrition inresource-poor settings. Periodic mass deworming with anthelminthic drugs remains the cornerstone ofhookworm control efforts worldwide. Reinfection following treatment occurs, reflecting the humanhost's inability to acquire immunity following exposure to an untreated reservoir of infection. Thiscluster randomized trial will evaluate the effectiveness of a modified, population-based, massdeworming strategy in reducing hookworm infection in an endemic southern Indian population.Methods: Forty five tribal villages were randomized into three groups: one received annual treatment;the second received two rounds of treatment at 1-month intervals; and the third received four rounds oftreatment e two rounds 1 month apart at the beginning, followed by another two after 6 months. Stoolsamples collected through cross-sectional parasitological surveys pre- and post-intervention, and at 3-monthly intervals for a period of 1 year were tested for presence of hookworm ova. Long-term effectivenessof treatment will be assessed through another survey conducted 2 years after the last treatmentcycle.Results: From a population of 11,857 individuals, 8681 (73.2%) were found to be eligible and consented toparticipate, out-migration being the primary reason for non-participation. Baseline stool samples wereobtained from 2082 participants, with 18.5% having hookworm infection, although majority were lowintensity infections (<2000 eggs per gram of feces).Discussion: This study will help identify the optimal mass deworming strategy that can achieve thegreatest impact in the shortest period of time, particularly in settings where long-term program sustainabilityis a challenge
AU - Sarkar,R
AU - Rose,A
AU - Mohan,VR
AU - Ajjampur,SSR
AU - Veluswamy,V
AU - Srinivasan,R
AU - Muliyil,J
AU - Rajshekhar,V
AU - George,K
AU - Balraj,V
AU - Grassly,NC
AU - Anderson,RM
AU - Brooker,SJ
AU - Kang,G
DO - 10.1016/j.conctc.2016.12.002
EP - 55
PY - 2016///
SN - 2451-8654
SP - 49
TI - Study design and baseline results of an open-label cluster randomized community-intervention trial to assess the effectiveness of a modified mass deworming program in reducing hookworm infection in a tribal population in southern India
T2 - Contemporary Clinical Trials Communications
UR - http://dx.doi.org/10.1016/j.conctc.2016.12.002
UR - http://hdl.handle.net/10044/1/54561
VL - 5
ER -