Imperial College London

ProfessorNicholasGrassly

Faculty of MedicineSchool of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3264n.grassly Website

 
 
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Location

 

G36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{John:2016:infdis/jiw595,
author = {John, J and Giri, S and Karthikeyan, AS and Lata, D and Jeyapaul, S and Rajan, AK and Kumar, N and Dhanapal, P and Venkatesan, J and Mani, M and Hanusha, J and Raman, U and Moses, PD and Abraham, A and Bahl, S and Bandyopadhyay, AS and Ahmad, M and Grassly, NC and Kang, G},
doi = {infdis/jiw595},
journal = {Journal of Infectious Diseases},
pages = {529--536},
title = {The duration of intestinal immunity after an inactivated poliovirus vaccine booster dose in children immunized with oral vaccine: a randomized controlled trial},
url = {http://dx.doi.org/10.1093/infdis/jiw595},
volume = {215},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Background.In 2014, 2 studies showed that inactivated poliovirus vaccine (IPV) boosts intestinal immunity in children previously immunized with oral poliovirus vaccine (OPV). As a result, IPV was introduced in mass campaigns to help achieve polio eradication.Methods.We conducted an open-label, randomized, controlled trial to assess the duration of the boost in intestinal immunity following a dose of IPV given to OPV-immunized children. Nine hundred healthy children in Vellore, India, aged 1–4 years were randomized (1:1:1) to receive IPV at 5 months (arm A), at enrollment (arm B), or no vaccine (arm C). The primary outcome was poliovirus shedding in stool 7 days after bivalent OPV challenge at 11 months.Results.For children in arms A, B, and C, 284 (94.7%), 297 (99.0%), and 296 (98.7%), respectively, were eligible for primary per-protocol analysis. Poliovirus shedding 7 days after challenge was less prevalent in arms A and B compared with C (24.6%, 25.6%, and 36.4%, respectively; risk ratio 0.68 [95% confidence interval: 0.53–0.87] for A versus C, and 0.70 [0.55–0.90] for B versus C).Conclusions.Protection against poliovirus remained elevated 6 and 11 months after an IPV boost, although at a lower level than reported at 1 month.
AU - John,J
AU - Giri,S
AU - Karthikeyan,AS
AU - Lata,D
AU - Jeyapaul,S
AU - Rajan,AK
AU - Kumar,N
AU - Dhanapal,P
AU - Venkatesan,J
AU - Mani,M
AU - Hanusha,J
AU - Raman,U
AU - Moses,PD
AU - Abraham,A
AU - Bahl,S
AU - Bandyopadhyay,AS
AU - Ahmad,M
AU - Grassly,NC
AU - Kang,G
DO - infdis/jiw595
EP - 536
PY - 2016///
SN - 0022-1899
SP - 529
TI - The duration of intestinal immunity after an inactivated poliovirus vaccine booster dose in children immunized with oral vaccine: a randomized controlled trial
T2 - Journal of Infectious Diseases
UR - http://dx.doi.org/10.1093/infdis/jiw595
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000398422100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/45609
VL - 215
ER -