Imperial College London

ProfessorNicholasGrassly

Faculty of MedicineSchool of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3264n.grassly Website

 
 
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Location

 

G36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{O'Reilly:2017:10.1186/s12879-017-2443-4,
author = {O'Reilly, KM and Lamoureux, C and Molodecky, NA and Lyons, H and Grassly, NC and Tallis, G},
doi = {10.1186/s12879-017-2443-4},
journal = {BMC Infectious Diseases},
title = {An assessment of the geographical risks of wild and vaccine-derived poliomyelitis outbreaks in Africa and Asia},
url = {http://dx.doi.org/10.1186/s12879-017-2443-4},
volume = {17},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BackgroundThe international spread of wild poliomyelitis outbreaks continues to threaten eradication of poliomyelitis and in 2014 a public health emergency of international concern was declared. Here we describe a risk scoring system that has been used to assess country-level risks of wild poliomyelitis outbreaks, to inform prioritisation of mass vaccination planning, and describe the change in risk from 2014 to 2016. The methods were also used to assess the risk of emergence of vaccine-derived poliomyelitis outbreaks.MethodsPotential explanatory variables were tested against the reported outbreaks of wild poliomyelitis since 2003 using multivariable regression analysis. The regression analysis was translated to a risk score and used to classify countries as Low, Medium, Medium High and High risk, based on the predictive ability of the score.ResultsIndicators of population immunity, population displacement and diarrhoeal disease were associated with an increased risk of both wild and vaccine-derived outbreaks. High migration from countries with wild cases was associated with wild outbreaks. High birth numbers were associated with an increased risk of vaccine-derived outbreaks.ConclusionsUse of the scoring system is a transparent and rapid approach to assess country risk of wild and vaccine-derived poliomyelitis outbreaks. Since 2008 there has been a steep reduction in the number of wild poliomyelitis outbreaks and the reduction in countries classified as High and Medium High risk has reflected this. The risk of vaccine-derived poliomyelitis outbreaks has varied geographically. These findings highlight that many countries remain susceptible to poliomyelitis outbreaks and maintenance or improvement in routine immunisation is vital.
AU - O'Reilly,KM
AU - Lamoureux,C
AU - Molodecky,NA
AU - Lyons,H
AU - Grassly,NC
AU - Tallis,G
DO - 10.1186/s12879-017-2443-4
PY - 2017///
SN - 1471-2334
TI - An assessment of the geographical risks of wild and vaccine-derived poliomyelitis outbreaks in Africa and Asia
T2 - BMC Infectious Diseases
UR - http://dx.doi.org/10.1186/s12879-017-2443-4
UR - http://hdl.handle.net/10044/1/48417
VL - 17
ER -