Imperial College London

ProfessorNicholasGrassly

Faculty of MedicineSchool of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
//

Contact

 

+44 (0)20 7594 3264n.grassly Website

 
 
//

Location

 

G36Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Parker:2017:10.1038/s41598-017-06862-0,
author = {Parker, EPK and Praharaj, I and John, J and Kaliappan, SP and Kampmann, B and Kang, G and Grassly, NC},
doi = {10.1038/s41598-017-06862-0},
journal = {Scientific Reports},
title = {Changes in the intestinal microbiota following the administration of azithromycin in a randomised placebo-controlled trial among infants in south India},
url = {http://dx.doi.org/10.1038/s41598-017-06862-0},
volume = {7},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Macrolides are among the most widely prescribed antibiotics worldwide. However, their impact on the gut’s bacterial microbiota remains uncertain. We characterised the intestinal microbiota in 6–11 month-old infants in India who received a 3-day course of azithromycin or placebo during a randomised trial of oral poliovirus vaccine immunogenicity (CTRI/2014/05/004588). In 60 infants per study arm, we sequenced the V4 region of the bacterial 16S rRNA gene in stool samples collected before and 12 days after finishing treatment. We also tested for the presence of common bacterial, viral, and eukaryotic enteropathogens in the same samples using real-time PCR in a Taqman array card (TAC) format. Azithromycin induced a modest decline in microbiota richness and a shift in taxonomic composition driven by a reduction in the relative abundance of Proteobacteria and Verrucomicrobia (specifically Akkermansia muciniphila). The former phylum includes pathogenic strains of Escherichia coli and Campylobacter spp. that declined in prevalence based on the TAC assay. These findings differ from previous observations among older children and adults in Europe and North America, suggesting that the effects of azithromycin on the bacterial flora may be specific to the age and geographic setting of its recipients.
AU - Parker,EPK
AU - Praharaj,I
AU - John,J
AU - Kaliappan,SP
AU - Kampmann,B
AU - Kang,G
AU - Grassly,NC
DO - 10.1038/s41598-017-06862-0
PY - 2017///
SN - 2045-2322
TI - Changes in the intestinal microbiota following the administration of azithromycin in a randomised placebo-controlled trial among infants in south India
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/s41598-017-06862-0
UR - http://hdl.handle.net/10044/1/49475
VL - 7
ER -