Imperial College London

ProfessorNicholasGrassly

Faculty of MedicineSchool of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3264n.grassly Website

 
 
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Location

 

G36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sindhu:2017:10.1136/bmjopen-2017-016577,
author = {Sindhu, KNC and Cunliffe, N and Peak, M and Turner, M and Darby, A and Grassly, N and Gordon, M and Dube, Q and Babji, S and Praharaj, I and Verghese, V and Iturriza-Gomara, M and Kang, G},
doi = {10.1136/bmjopen-2017-016577},
journal = {BMJ Open},
title = {Impact of maternal antibodies and infant gut microbiota on the immunogenicity of rotavirus vaccines in African, Indian and European infants: protocol for a prospective cohort study},
url = {http://dx.doi.org/10.1136/bmjopen-2017-016577},
volume = {7},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Introduction Gastroenteritis is the leading cause of morbidity and mortality among young children living in resource-poor settings, majority of which is attributed to rotavirus. Rotavirus vaccination can therefore have a significant impact on infant mortality. However, rotavirus vaccine efficacy in Sub-Saharan Africa and Southeast Asia is significantly lower than in high-income countries. Maternally derived antibodies, infant gut microbiota and concomitant oral polio vaccination have been proposed as potential reasons for poor vaccine performance in low-income settings. The overall aim of this study is to compare the role of maternally derived antibodies and infant gut microbiota in determining immune response to rotavirus vaccine in high-income and low-income settings, using the same vaccine and a similar study protocol.Methods and analysis The study is an observational cohort in three countries—Malawi, India and UK. Mothers will be enrolled in third trimester of pregnancy and followed up, along with infants after delivery, until the infant completes two doses of oral rotavirus vaccine (along with routine immunisation). The levels of prevaccination maternally derived rotavirus-specific antibodies (IgG) will be correlated with infant seroconversion and antibody titres, 4weeks after the second dose of rotavirus vaccine. Both within-country and between-country comparisons of gut microbiome will be carried out between children who seroconvert and those who do not. The impact of oral polio vaccine coadministration on rotavirus vaccine response will be studied in Indian infants.Ethics and dissemination Ethical approvals have been obtained from Integrated Research Application System (IRAS, NHS ethics) in UK, College of Medicine Research and Ethics Committee (COMREC) in Malawi and Institutional Review Board (IRB), Christian Medical College, Vellore in India. Participant recruitment and follow-up is ongoing at all three sites. Analysis of data, followed by publicatio
AU - Sindhu,KNC
AU - Cunliffe,N
AU - Peak,M
AU - Turner,M
AU - Darby,A
AU - Grassly,N
AU - Gordon,M
AU - Dube,Q
AU - Babji,S
AU - Praharaj,I
AU - Verghese,V
AU - Iturriza-Gomara,M
AU - Kang,G
DO - 10.1136/bmjopen-2017-016577
PY - 2017///
SN - 2044-6055
TI - Impact of maternal antibodies and infant gut microbiota on the immunogenicity of rotavirus vaccines in African, Indian and European infants: protocol for a prospective cohort study
T2 - BMJ Open
UR - http://dx.doi.org/10.1136/bmjopen-2017-016577
UR - http://hdl.handle.net/10044/1/53769
VL - 7
ER -