Imperial College London

ProfessorNicholasGrassly

Faculty of MedicineSchool of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3264n.grassly Website

 
 
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Location

 

G36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lazarus:2017:10.1016/j.vaccine.2017.07.116,
author = {Lazarus, RP and John, J and Shanmugasundaram, E and Rajan, AK and Thiagarajan, S and Giri, S and Babji, S and Sarkar, R and Kaliappan, PS and Venugopal, S and Praharaj, I and Raman, U and Paranjpe, M and Grassly, NC and Parker, EPK and Parashar, UD and Tate, JE and Fleming, JA and Steele, AD and Muliyil, J and Abraham, AM and Kang, G},
doi = {10.1016/j.vaccine.2017.07.116},
journal = {Vaccine},
pages = {273--279},
title = {The effect of probiotics and zinc supplementation on the immune response to oral rotavirus vaccine: A randomized, factorial design, placebo-controlled study among Indian infants},
url = {http://dx.doi.org/10.1016/j.vaccine.2017.07.116},
volume = {36},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BackgroundStrategies are needed to improve oral rotavirus vaccine (RV), which provides suboptimal protection in developing countries. Probiotics and zinc supplementation could improve RV immunogenicity by altering the intestinal microbiota and immune function.MethodsInfants 5 weeks old living in urban Vellore, India were enrolled in a randomized, double-blind, placebo-controlled trial with a 4-arm factorial design to assess the effects of daily zinc (5 mg), probiotic (1010 Lactobacillus rhamnosus GG) or placebo on the immunogenicity of two doses of RV (Rotarix®, GlaxoSmithKline Biologicals) given at 6 and 10 weeks of age. Infants were eligible for participation if healthy, available for the study duration and without prior receipt of RV or oral poliovirus vaccine other than the birth dose. The primary outcome was seroconversion to rotavirus at 14 weeks of age based on detection of VP6-specific IgA at ≥20 U/ml in previously seronegative infants or a fourfold rise in concentration.ResultsThe study took place during July 2012 to February 2013. 620 infants were randomized equally between study arms and 551 (88.9%) completed per protocol. Seroconversion was recorded in 54/137 (39.4%), 42/136 (30.9%), 40/143 (28.0%), and 37/135 (27.4%) infants receiving (1) probiotic and zinc, (2) probiotic and placebo, (3) placebo and zinc, (4) two placebos. Seroconversion showed a modest improvement among infants receiving probiotic (difference between groups 1, 2 and 3, 4 was 7.5% (97.5% Confidence Interval (CI): −1.4%, 16.2%), p = 0.066) but not zinc (difference between groups 1, 3 and 2, 4 was 4.4% (97.5% CI: −4.4%, 13.2%), p = 0.272). 16 serious adverse events were recorded, none related to study interventions.ConclusionsZinc or probiotic supplementation did not significantly improve the low immunogenicity of rotavirus vaccine given to infants in a poor urban community in India. A modest effect of combined supplementation deserves further investigation.
AU - Lazarus,RP
AU - John,J
AU - Shanmugasundaram,E
AU - Rajan,AK
AU - Thiagarajan,S
AU - Giri,S
AU - Babji,S
AU - Sarkar,R
AU - Kaliappan,PS
AU - Venugopal,S
AU - Praharaj,I
AU - Raman,U
AU - Paranjpe,M
AU - Grassly,NC
AU - Parker,EPK
AU - Parashar,UD
AU - Tate,JE
AU - Fleming,JA
AU - Steele,AD
AU - Muliyil,J
AU - Abraham,AM
AU - Kang,G
DO - 10.1016/j.vaccine.2017.07.116
EP - 279
PY - 2017///
SN - 0264-410X
SP - 273
TI - The effect of probiotics and zinc supplementation on the immune response to oral rotavirus vaccine: A randomized, factorial design, placebo-controlled study among Indian infants
T2 - Vaccine
UR - http://dx.doi.org/10.1016/j.vaccine.2017.07.116
UR - http://hdl.handle.net/10044/1/52877
VL - 36
ER -