Imperial College London

ProfessorNicholasGrassly

Faculty of MedicineSchool of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3264n.grassly Website

 
 
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Location

 

G36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Giri:2018:infdis/jix687,
author = {Giri, S and Kumar, N and Dhanapal, P and Venkatesan, J and Kasirajan, A and Iturriza-Gomara, M and John, J and Abraham, AM and Grassly, NC and Kang, G},
doi = {infdis/jix687},
journal = {JOURNAL OF INFECTIOUS DISEASES},
pages = {1395--1398},
title = {Quantity of Vaccine Poliovirus Shed Determines the Titer of the Serum Neutralizing Antibody Response in Indian Children Who Received Oral Vaccine},
url = {http://dx.doi.org/10.1093/infdis/jix687},
volume = {217},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Replication of oral poliovirus vaccine (OPV) in the intestine (ie, vaccine take) is associated with seroconversion and protection against poliomyelitis. We used quantitative polymerase chain reaction analysis to measure vaccine shedding in 300 seronegative infants aged 6–11 months and in 218 children aged 1–4 years 7 days after administration of monovalent or bivalent OPV. We found that the quantity of shedding correlated with the magnitude of the serum neutralizing antibody response measured 21 or 28 days after vaccination. This suggests that the immune response to OPV is on a continuum, rather than an all-or-nothing phenomenon, that depends on efficient vaccine virus replication.
AU - Giri,S
AU - Kumar,N
AU - Dhanapal,P
AU - Venkatesan,J
AU - Kasirajan,A
AU - Iturriza-Gomara,M
AU - John,J
AU - Abraham,AM
AU - Grassly,NC
AU - Kang,G
DO - infdis/jix687
EP - 1398
PY - 2018///
SN - 0022-1899
SP - 1395
TI - Quantity of Vaccine Poliovirus Shed Determines the Titer of the Serum Neutralizing Antibody Response in Indian Children Who Received Oral Vaccine
T2 - JOURNAL OF INFECTIOUS DISEASES
UR - http://dx.doi.org/10.1093/infdis/jix687
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430729300009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/59937
VL - 217
ER -