Imperial College London

ProfessorNicholasGrassly

Faculty of MedicineSchool of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3264n.grassly Website

 
 
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Location

 

G36Medical SchoolSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

114 results found

Church JA, Parker EP, Kirkpatrick BD, Grassly NC, Prendergast AJet al., 2019, Interventions to improve oral vaccine performance: a systematic review and meta-analysis, LANCET INFECTIOUS DISEASES, Vol: 19, Pages: 203-214, ISSN: 1473-3099

JOURNAL ARTICLE

Parker EPK, Whitfield H, Baskar C, Giri S, John J, Grassly NC, Kang G, Praharaj Iet al., 2019, FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants., J Infect Dis, Vol: 219, Pages: 578-581

FUT2 determines whether histo-blood group antigens are secreted at mucosal surfaces. Secretor status influences susceptibility to enteric viruses, potentially including oral poliovirus vaccine (OPV). We performed a nested case-control study to determine the association between FUT2 genotype (single-nucleotide polymorphisms G428A, C302T, and A385T) and seroconversion among Indian infants who received a single dose of monovalent type 3 OPV. Secretor prevalence was 75% (89 of 118) in infants who seroconverted and 80% (97 of 122) in infants who did not seroconvert (odds ratio, 0.79; 95% confidence interval, .43-1.45). Our findings suggest that FUT2 genotype is not a key determinant of variation in OPV immunogenicity.

JOURNAL ARTICLE

Grassly NC, Orenstein WA, 2018, Securing the Eradication of All Polioviruses, CLINICAL INFECTIOUS DISEASES, Vol: 67, Pages: S1-S3, ISSN: 1058-4838

JOURNAL ARTICLE

Grassly NC, Wadood MZ, Safdar RM, Mahamud AS, Sutter RWet al., 2018, Effect of Inactivated Poliovirus Vaccine Campaigns, Pakistan, 2014-2017, EMERGING INFECTIOUS DISEASES, Vol: 24, Pages: 2113-2115, ISSN: 1080-6040

JOURNAL ARTICLE

Praharaj I, Parker EPK, Giri S, Allen DJ, Silas S, Revathi R, Kaliappan SP, John J, Prasad JH, Kampmann B, Iturriza-Gómara M, Grassly NC, Kang Get al., 2018, Influence of non-polio enteroviruses and the bacterial gut microbiota on oral poliovirus vaccine response: a study from south India., J Infect Dis

Background: Oral poliovirus vaccine (OPV) is less immunogenic in LMIC countries. We tested whether bacterial and viral components of the intestinal microbiota are associated with this phenomenon. Methods: We assessed prevalence of enteropathogens using TaqMan array cards 14 days before and at vaccination in 704 Indian infants (6-11 months) receiving monovalent type3 OPV (CTRI/2014/05/004588). Non-polio enterovirus (NPEV) serotypes were identified by VP1 sequencing. In 120 infants, pre-vaccination bacterial microbiota was characterised by 16S rRNA sequencing. Results: We detected 56 NPEV serotypes on the day of vaccination. Concurrent NPEVs were associated with a reduction in OPV seroconversion, consistent across species (odds ratios and 95% CIs of 0·57[0·36-0·90], 0·61[0·43-0·86], and 0·69[0·41-1·16] for species A, B, and C, respectively). Recently acquired enterovirus infections,detected at vaccination, but not 14 days earlier had greater interfering effect on mOPV3 sero-response compared to persistent infections,with enterovirus detected at both time points (44/127[35%] vs 63/129[49%] seroconversion,p=0.021). Abundance of specific bacterial taxa did not differ significantly according to OPV response, although microbiota diversity was higher in non-responders at the time of vaccination. Conclusion: Enteric viruses have greater impact on OPV response than the bacterial microbiota with recent enterovirus infections having greater inhibitory effect than persistent infections.

JOURNAL ARTICLE

Blake IM, Pons-Salort M, Molodecky NA, Diop OM, Chenoweth P, Bandyopadhyay AS, Zaffran M, Sutter RW, Grassly NCet al., 2018, Type 2 Poliovirus Detection after Global Withdrawal of Trivalent Oral Vaccine, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 379, Pages: 834-845, ISSN: 0028-4793

JOURNAL ARTICLE

Pons-Salort M, Grassly NC, 2018, Serotype-specific immunity explains the incidence of diseases caused by human enteroviruses, SCIENCE, Vol: 361, Pages: 800-803, ISSN: 0036-8075

JOURNAL ARTICLE

Parker EPK, Grassly NC, 2018, Enhancing Rotavirus Vaccination: A Microbial Fix?, CELL HOST & MICROBE, Vol: 24, Pages: 195-196, ISSN: 1931-3128

JOURNAL ARTICLE

Church JA, Parker EPK, Kosek MN, Kang G, Grassly NC, Kelly P, Prendergast AJet al., 2018, Exploring the relationship between environmental enteric dysfunction and oral vaccine responses, FUTURE MICROBIOLOGY, Vol: 13, Pages: 1055-1070, ISSN: 1746-0913

JOURNAL ARTICLE

Grassly NC, 2018, Eradicating polio with a vaccine we must stop using, LANCET INFECTIOUS DISEASES, Vol: 18, Pages: 590-591, ISSN: 1473-3099

JOURNAL ARTICLE

Giri S, Kumar N, Dhanapal P, Venkatesan J, Kasirajan A, Iturriza-Gomara M, John J, Abraham AM, Grassly NC, Kang Get al., 2018, Quantity of Vaccine Poliovirus Shed Determines the Titer of the Serum Neutralizing Antibody Response in Indian Children Who Received Oral Vaccine, JOURNAL OF INFECTIOUS DISEASES, Vol: 217, Pages: 1395-1398, ISSN: 0022-1899

JOURNAL ARTICLE

O'Reilly KM, Verity R, Durry E, Asghar H, Sharif S, Zaidi SZ, Wadood MZM, Diop OM, Okayasu H, Safdar RM, Grassly NCet al., 2018, Population sensitivity of acute flaccid paralysis and environmental surveillance for serotype 1 poliovirus in Pakistan: an observational study, BMC INFECTIOUS DISEASES, Vol: 18, ISSN: 1471-2334

JOURNAL ARTICLE

Pons-Salort M, Oberste MS, Pallansch MA, Abedi GR, Takahashi S, Grenfell BT, Grassly NCet al., 2018, The seasonality of nonpolio enteroviruses in the United States: Patterns and drivers, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 115, Pages: 3078-3083, ISSN: 0027-8424

JOURNAL ARTICLE

Imran H, Raja D, Grassly NC, Wadood MZ, Safdar RM, O'Reilly KMet al., 2018, Routine immunization in Pakistan: comparison of multiple data sources and identification of factors associated with vaccination, INTERNATIONAL HEALTH, Vol: 10, Pages: 84-91, ISSN: 1876-3413

JOURNAL ARTICLE

Parker EPK, Praharaj I, Zekavati A, Lazarus RP, Giri S, Operario DJ, Liu J, Houpt E, Iturriza-Gomara M, Kampmann B, John J, Kang G, Grassly NCet al., 2018, Influence of the intestinal microbiota on the immunogenicity of oral rotavirus vaccine given to infants in south India, VACCINE, Vol: 36, Pages: 264-272, ISSN: 0264-410X

JOURNAL ARTICLE

Lazarus RP, John J, Shanmugasundaram E, Rajan AK, Thiagarajan S, Giri S, Babji S, Sarkar R, Kaliappan PS, Venugopal S, Praharaj I, Raman U, Paranjpe M, Grassly NC, Parker EPK, Parashar UD, Tate JE, Fleming JA, Steele AD, Muliyil J, Abraham AM, Kang Get al., 2018, The effect of probiotics and zinc supplementation on the immune response to oral rotavirus vaccine: A randomized, factorial design, placebo-controlled study among Indian infants, VACCINE, Vol: 36, Pages: 273-279, ISSN: 0264-410X

JOURNAL ARTICLE

Parker EPK, Ramani S, Lopman BA, Church JA, Iturriza-Gomara M, Prendergast AJ, Grassly NCet al., 2018, Causes of impaired oral vaccine efficacy in developing countries, FUTURE MICROBIOLOGY, Vol: 13, Pages: 97-118, ISSN: 1746-0913

JOURNAL ARTICLE

Li LM, Grassly NC, Fraser C, 2017, Quantifying Transmission Heterogeneity Using Both Pathogen Phylogenies and Incidence Time Series, MOLECULAR BIOLOGY AND EVOLUTION, Vol: 34, Pages: 2982-2995, ISSN: 0737-4038

JOURNAL ARTICLE

Parker EPK, Praharaj I, John J, Kaliappan SP, Kampmann B, Kang G, Grassly NCet al., 2017, Changes in the intestinal microbiota following the administration of azithromycin in a randomised placebo-controlled trial among infants in south India, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Molodecky NA, Blake IM, O'Reilly KM, Wadood MZ, Safdar RM, Wesolowski A, Buckee CO, Bandyopadhyay AS, Okayasu H, Grassly NCet al., 2017, Risk factors and short-term projections for serotype-1 poliomyelitis incidence in Pakistan: A spatiotemporal analysis, PLOS MEDICINE, Vol: 14, ISSN: 1549-1676

JOURNAL ARTICLE

O'Reilly KM, Lamoureux C, Molodecky NA, Lyons H, Grassly NC, Tallis Get al., 2017, An assessment of the geographical risks of wild and vaccine-derived poliomyelitis outbreaks in Africa and Asia, BMC INFECTIOUS DISEASES, Vol: 17, ISSN: 1471-2334

JOURNAL ARTICLE

Sarkar R, Rose A, Mohan VR, Ajjampur SSR, Veluswamy V, Srinivasan R, Muliyil J, Rajshekhar V, George K, Balraj V, Grassly NC, Anderson RM, Brooker SJ, Kang Get al., 2017, Study design and baseline results of an open-label cluster randomized community-intervention trial to assess the effectiveness of a modified mass deworming program in reducing hookworm infection in a tribal population in southern India, CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS, Vol: 5, Pages: 49-55, ISSN: 2451-8654

JOURNAL ARTICLE

Sindhu KNC, Cunliffe N, Peak M, Turner M, Darby A, Grassly N, Gordon M, Dube Q, Babji S, Praharaj I, Verghese V, Iturriza-Gomara M, Kang Get al., 2017, Impact of maternal antibodies and infant gut microbiota on the immunogenicity of rotavirus vaccines in African, Indian and European infants: protocol for a prospective cohort study, BMJ OPEN, Vol: 7, ISSN: 2044-6055

JOURNAL ARTICLE

John J, Giri S, Karthikeyan AS, Lata D, Jeyapaul S, Rajan AK, Kumar N, Dhanapal P, Venkatesan J, Mani M, Hanusha J, Raman U, Moses PD, Abraham A, Bahl S, Bandyopadhyay AS, Ahmad M, Grassly NC, Kang Get al., 2017, The Duration of Intestinal Immunity After an Inactivated Poliovirus Vaccine Booster Dose in Children Immunized With Oral Vaccine: A Randomized Controlled Trial, JOURNAL OF INFECTIOUS DISEASES, Vol: 215, Pages: 529-536, ISSN: 0022-1899

JOURNAL ARTICLE

Shirreff G, Wadood MZ, Vaz RG, Sutter RW, Grassly NCet al., 2017, Estimated Effect of Inactivated Poliovirus Vaccine Campaigns, Nigeria and Pakistan, January 2014-April 2016, EMERGING INFECTIOUS DISEASES, Vol: 23, Pages: 258-263, ISSN: 1080-6040

JOURNAL ARTICLE

Parker EPK, Grassly NC, 2016, Unravelling mucosal immunity to poliovirus, LANCET INFECTIOUS DISEASES, Vol: 16, Pages: 1310-1311, ISSN: 1473-3099

JOURNAL ARTICLE

Pons-Salort M, Molodecky NA, O'Reilly KM, Wadood MZ, Safdar RM, Etsano A, Vaz RG, Jafari H, Grassly NC, Blake IMet al., 2016, Population Immunity against Serotype-2 Poliomyelitis Leading up to the Global Withdrawal of the Oral Poliovirus Vaccine: Spatio-temporal Modelling of Surveillance Data, PLOS MEDICINE, Vol: 13, ISSN: 1549-1676

JOURNAL ARTICLE

Mangal TD, Aylward RB, Shuaib F, Mwanza M, Pate MA, Abanida E, Grasslyl NCet al., 2016, Spatial Dynamics and High Risk Transmission Pathways of Poliovirus in Nigeria 2001-2013, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Kaliappan SP, Venugopal S, Giri S, Praharaj I, Karthikeyan AS, Babji S, John J, Muliyil J, Grassly N, Kang Get al., 2016, Factors determining anti-poliovirus type 3 antibodies among orally immunised Indian infants, VACCINE, Vol: 34, Pages: 4979-4984, ISSN: 0264-410X

JOURNAL ARTICLE

Grassly NC, Praharaj I, Babji S, Kaliappan SP, Giri S, Venugopal S, Parker EPK, Abraham A, Muliyil J, Doss S, Raman U, Liu J, Peter JV, Paranjape M, Jeyapaul S, Balakumar S, Ravikumar J, Srinivasan R, Bahl S, Iturriza-Gomara M, Uhlig HH, Houpt ER, John J, Kang Get al., 2016, The effect of azithromycin on the immunogenicity of oral poliovirus vaccine: a double-blind randomised placebo-controlled trial in seronegative Indian infants, LANCET INFECTIOUS DISEASES, Vol: 16, Pages: 905-914, ISSN: 1473-3099

JOURNAL ARTICLE

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