Imperial College London
Alternate

ProfessorNicholasGrassly

Faculty of Medicine, School of Public Health

Prof of Infectious Disease & Vaccine Epidemiology
 
 
 
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Contact

 

n.grassly Website

 
 
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Location

 

1102Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jorgensen:2020:ve/veaa040,
author = {Jorgensen, D and Pons, Salort M and Shaw, A and Grassly, N},
doi = {ve/veaa040},
journal = {Virus Evolution},
title = {The role of genetic sequencing and analysis in the polio eradication program},
url = {http://dx.doi.org/10.1093/ve/veaa040},
volume = {6},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Genetic sequencing of polioviruses detected through clinical and environmental surveillance is used to confirm detection, identify their likely origin, track geographic patterns of spread and determine the appropriate vaccination response. The critical importance of genetic sequencing and analysis to the Global Polio Eradication Initiative has grown with the increasing incidence of vaccine-derived poliovirus infections in Africa specifically (470 reported cases in 2019), and globally, alongside persistent transmission of serotype 1 wild-type poliovirus in Pakistan and Afghanistan (197 reported cases in 2019). Adapting what has been learned about the virus genetics and evolution to address these threats has been a major focus of recent work. Here we review how phylogenetic and phylogeographic methods have been used to trace the spread of wild-type polioviruses and identify the likely origins of vaccine-derived polioviruses. We highlight the analysis methods and sequencing technology currently used and the potential for new technologies to speed up poliovirus detection and the interpretation of genetic data. At a pivotal point in the eradication campaign with the threat of anti-vaccine sentiment and donor and public fatigue, innovation is critical to maintain drive and overcome the last remaining circulating virus.
AU  - Jorgensen,D
AU  - Pons,Salort M
AU  - Shaw,A
AU  - Grassly,N
DO  - ve/veaa040
PY  - 2020///
SN  - 2057-1577
TI  - The role of genetic sequencing and analysis in the polio eradication program
T2  - Virus Evolution
UR  - http://dx.doi.org/10.1093/ve/veaa040
UR  - https://academic.oup.com/ve/article/doi/10.1093/ve/veaa040/5841225
UR  - http://hdl.handle.net/10044/1/80235
VL  - 6
ER  -
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