Imperial College London

Dr Nadia Guerra

Faculty of Natural SciencesDepartment of Life Sciences

Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5663n.guerra

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Dr Guerra established her lab in the Department of Life Sciences in October 2009 as a Wellcome Trust fellow and was appointed as a lecturer/assistant Professor in February 2013. Her research aims to elucidate the physiologic relevance of immunoreceptors expressed by Natural Killer (NK) cells in the development of immunopathologies and cancer.  An additional focus in the lab relies on combining state-of-the-art multi-photon imaging with novel mouse models to investigate the behavior of NK cells during chronic inflammation with the view of understanding the role they play in cancer progression. 


Nadia received her Ph.D. from the University Paris VI, Pierre et Marie Curie, Paris  in 2002 where she studied the role of inhibitory NK cell receptors in kidney cancer at the Institut Gustave Roussy in Villejuif, France.  She joined the group of Prof. David Raulet at the University of Berkeley, California to complete her postdoctoral training focusing on the role of NK group 2, member D (NKG2D) in vivo. She made a significant contribution to the NK cell field through the generation of NKG2D-deficient mice, instrumental to the understanding of NK cell function in disease models.

 

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 Our lab has uncovered a novel and unexpected role for NKG2D in its capacity to promote rather than delay tumorigenesis in models of inflammation-driven Cancer. This work was presented at the 16th annual meeting of the Society for Natural Immunity in Taormina, Sicily.

The manuscript entitled " The Immunoreceptor NKG2D promotes tumor growth in a model of hepatocellular carcinoma" is currently in press at Nature Communications.

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Students (Ph.D or Post-doc level) interested in joining the lab should email their resume and cover letter to Dr Guerra (n.guerra@imperial.ac.uk)

Publications

Journals

Sheppard S, Guedes J, Mroz A, et al., 2017, The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma, Nature Communications, Vol:8, ISSN:2041-1723

Collery P, Mohsen A, Kermagoret A, et al., 2015, Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer, Investigational New Drugs, Vol:33, ISSN:0167-6997, Pages:848-860

Sparks H, Warren S, Guedes J, et al., 2015, A flexible wide-field FLIM endoscope utilising blue excitation light for label-free contrast of tissue, Journal of Biophotonics, Vol:8, ISSN:1864-063X, Pages:168-178

Basey-Fisher TH, Guerra N, Triulzi C, et al., 2014, Microwaving Blood as a Non-Destructive Technique for Haemoglobin Measurements on Microlitre Samples, Advanced Healthcare Materials, Vol:3, ISSN:2192-2640, Pages:536-542

Conference

Tomaz DT, Guerra N, Dyson JD, et al., Fluorescent tagged NK cell receptors expressed in vivo using retrogenic mice to study the delivery of signals in NK cells, International Congress of Immunology 2013

More Publications