Imperial College London
Dr Nadia Guerra

Dr Nadia Guerra

Faculty of Natural Sciences, Department of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5663n.guerra

 
 
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Location

 

604Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sheppard:2018:10.1016/j.celrep.2018.03.023,
author = {Sheppard, S and Schuster, IS and Andoniou, CE and Cocita, C and Adejumo, T and Kung, SKP and Sun, J and Degli-Esposti, MA and Guerra, N},
doi = {10.1016/j.celrep.2018.03.023},
journal = {Cell Reports},
pages = {3385--3392},
title = {The murine natural cytotoxic receptor NKp46/NCR1 controls TRAIL protein expression in NK cells and ILC1},
url = {http://dx.doi.org/10.1016/j.celrep.2018.03.023},
volume = {22},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - TRAIL is an apoptosis-inducing ligand constitutively expressed on liver resident type 1 innate lymphoid cells (ILC1) and a subset of Natural Killer (NK) cells where it contributes to NK cell anti-tumor, anti-viral and immunoregulatory functions.  Yet the intrinsic pathways involved in TRAIL expression in ILC remain unidentified. Here we demonstrate that the murine natural cytotoxic receptor mNKp46/NCR1, expressed on ILC1 and NK cells, controls TRAIL protein expression. Using NKp46-deficient mice, we show that liver ILC1 lack constitutive expression of TRAIL protein and that NK cells activated in vitro and in vivo fail to upregulate cell-surface TRAIL in the absence of NKp46. We show that NKp46 regulates TRAIL expression in a dose-dependent manner and that the reintroduction of NKp46 in mature NK cells deficient for NKp46 is sufficient to restore TRAIL surface expression. These studies uncover a link between NKp46 and TRAIL expression in ILC with potential implications in pathologies involving NKp46-expressing cells.
AU  - Sheppard,S
AU  - Schuster,IS
AU  - Andoniou,CE
AU  - Cocita,C
AU  - Adejumo,T
AU  - Kung,SKP
AU  - Sun,J
AU  - Degli-Esposti,MA
AU  - Guerra,N
DO  - 10.1016/j.celrep.2018.03.023
EP  - 3392
PY  - 2018///
SN  - 2211-1247
SP  - 3385
TI  - The murine natural cytotoxic receptor NKp46/NCR1 controls TRAIL protein expression in NK cells and ILC1
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2018.03.023
UR  - http://hdl.handle.net/10044/1/57832
VL  - 22
ER  -
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