Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Reader in Respiratory Medicine







Muscle LabSouth BlockRoyal Brompton Campus





Nick Hopkinson is a Clinical Senior Lecturer at Imperial College as well as an Honorary Consultant Chest Physician at The Royal Brompton Hospital. He qualified in Medicine at Cambridge and The London Hospital Medical College and went on to train in Respiratory and General Internal Medicine at St George’s and St Thomas’ Hospitals. He is clinical lead for chronic obstructive pulmonary disease (COPD) at The Royal Brompton Hospital where he runs an advanced COPD clinic with Professor Mike Polkey and Dr Matthew Hind where patients are assessed for novel treatments for their disease including endobronchial emphysema therapies. He has established a smoking cessation clinic within the trust and is responsible for developing pulmonary rehabilitation services. Service development work includes the development of a COPD discharge care bundle working with the NW London CLAHRC. 

His major research interest is the causes of exercise limitation and reduced physical activity in patients with COPD. His publications have addressed the influence of genetic polymorphisms, corticosteroid therapy and the role of acute exacerbations in skeletal muscle impairment in this condition. He has also published work on the impact of bronchoscopic lung volume reduction on dynamic hyperinflation in patients with COPD and on transcranial magnetic stimulation of the diaphragm motor cortex in health and disease. He is a work package lead for the EU/IMI PROactive project developing a patient reported outcome for physical activity in COPD.

His work has been funded by The Medical Research Council, Wellcome Trust, The European Union, The British Lung Foundation and The Moulton Foundation. He works closely with Professor Mike Polkey and together with Professor John Moxham at King’s College Hospital and Dr Nick Hart at St Thomas’ they make up the London Respiratory Muscle Group which has undertaken a considerable body of collaborative research. Other external collaborations are with Professor Hugh Montgomery at UCH and he has also worked with Iranian physicians to improve the care, in particular through pulmonary rehabilitation, of victims of mustard gas from the Iran Iraq war in the 1980’s. Techniques employed include invasive measurement of respiratory pressures, cardiopulmonary exercise testing and the use of magnetic nerve stimulation to obtain non-volitional measures of muscle function.

He is a Fellow of The Royal College of Physicians and is on the Council of The British Thoracic Society where he serves on the Science and Research Committee. He is the editor of the BTS newsletter, a spokesperson on COPD for the British Lung Foundation and was a medical advisor for ‘The Smoke House’ TV programme produced by The BBC.


Selected Publications

Journal Articles

Curtis KJ, O'Brien KA, Tanner RJ, et al., 2015, Acute Dietary Nitrate Supplementation and Exercise Performance in COPD: A Double-Blind, Placebo-Controlled, Randomised Controlled Pilot Study, PLOS One, Vol:10, ISSN:1932-6203

Davey C, Zoumot Z, Jordan S, et al., 2015, Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (the BeLieVeR-HIFi study): a randomised controlled trial, The Lancet, Vol:386, ISSN:0140-6736, Pages:1066-1073

Faisal A, Zoumot Z, Shah PL, et al., 2016, Effective Bronchoscopic Lung Volume Reduction Accelerates Exercise Oxygen Uptake Kinetics in Emphysema, Chest, Vol:149, ISSN:0012-3692, Pages:435-446

Zoumot Z, LoMauro A, Aliverti A, et al., 2015, Lung Volume Reduction in Emphysema Improves Chest Wall Asynchrony, Chest, Vol:148, ISSN:0012-3692, Pages:185-195

Mendoza L, Horta P, Espinoza J, et al., 2015, Pedometers to enhance physical activity in COPD: a randomised controlled trial, European Respiratory Journal, Vol:45, ISSN:1399-3003, Pages:347-354

Maddocks M, Shrikrishna D, Vitoriano S, et al., 2014, Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD, European Respiratory Journal, Vol:44, ISSN:1399-3003, Pages:1188-1198

Shrikrishna D, Tanner RJ, Lee JY, et al., 2014, A Randomized Controlled Trial of Angiotensin-Converting Enzyme Inhibition for Skeletal Muscle Dysfunction in COPD, Chest, Vol:146, ISSN:1931-3543, Pages:932-940

Hopkinson NS, Lester-George A, Ormiston-Smith N, et al., 2013, Child uptake of smoking by area across the UK, Thorax, Vol:69, ISSN:0040-6376, Pages:873-875

Hopkinson NS, Englebretsen C, Cooley N, et al., 2012, Designing and implementing a COPD discharge care bundle, Thorax, Vol:67, ISSN:0040-6376, Pages:90-92

Boutou AK, Shrikrishna D, Tanner RJ, et al., 2013, Lung function indices for predicting mortality in COPD, European Respiratory Journal, Vol:42, ISSN:0903-1936, Pages:616-625

Dodd JW, Hogg L, Nolan J, et al., 2011, The COPD assessment test (CAT): response to pulmonary rehabilitation. A multicentre, prospective study, Thorax, Vol:66, ISSN:0040-6376, Pages:425-429

Hopkinson NS, Shah PL, Polkey MI, 2011, Endobronchial Valves for Emphysema, New England Journal of Medicine, Vol:364, ISSN:0028-4793, Pages:381-382

Falzon C, Elkin SL, Kelly JL, et al., 2011, Can financial incentives for improvements in healthcare quality enhance identification of COPD in primary care?, Thorax, Vol:66, ISSN:0040-6376, Pages:630-630

Hopkinson NS, Kemp SV, Toma TP, et al., 2011, Atelectasis and survival after bronchoscopic lung volume reduction for COPD, European Respiratory Journal, Vol:37, ISSN:0903-1936, Pages:1346-1351

Hopkinson NS, Li KW, Kehoe A, et al., 2008, Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease, American Journal of Clinical Nutrition, Vol:87, ISSN:0002-9165, Pages:385-390

Hopkinson NS, Eleftheriou KI, Payne J, et al., 2006, +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease, American Journal of Clinical Nutrition, Vol:83, ISSN:0002-9165, Pages:912-917

Hopkinson NS, Nickol AH, Payne J, et al., 2004, Angiotensin converting enzyme genotype and strength in chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, Vol:170, ISSN:1073-449X, Pages:395-399

Hopkinson NS, Toma TP, Hansell DM, et al., 2005, Effect of Bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema, American Journal of Respiratory and Critical Care Medicine, Vol:171, ISSN:1073-449X, Pages:453-460

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