Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Reader in Respiratory Medicine







Muscle LabSouth BlockRoyal Brompton Campus





Publication Type

413 results found

Zoumot Z, Jordan S, Hopkinson NS, Polkey MIet al., 2013, Twitch Transdiaphragmatic Pressure Morphology Can Distinguish Diaphragm Paralysis from a Diaphragm Defect, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 188, Pages: E3-E3, ISSN: 1073-449X

Journal article

Natanek SA, Riddoch-Contreras J, Marsh GS, Hopkinson NS, Moxham J, Man WD-C, Kemp PR, Polkey MIet al., 2013, MuRF-1 and Atrogin-1 Protein Expression and Quadriceps Fiber Size and Muscle Mass in Stable Patients with COPD, Copd-Journal of Chronic Obstructive Pulmonary Disease, Vol: 10, Pages: 618-624, ISSN: 1541-2563

Journal article

Hillman T, Mortimer F, Hopkinson NS, 2013, INHALED DRUGS AND GLOBAL WARMING Cost of switching inhalers is high in carbon trading terms Reply, BMJ-BRITISH MEDICAL JOURNAL, Vol: 347, ISSN: 1756-1833

Journal article

Hillman T, Mortimer F, Hopkinson NS, 2013, Inhaled drugs and global warming: time to shift to dry powder inhalers, BMJ-BRITISH MEDICAL JOURNAL, Vol: 346, ISSN: 1756-1833

Journal article

Shah PL, Zoumot Z, Singh S, Bicknell SR, Ross ET, Quiring J, Hopkinson NS, Kemp SVet al., 2013, Endobronchial coils for the treatment of severe emphysema with hyperinflation (RESET): a randomised controlled trial, Lancet, Vol: 1, Pages: 233-240, ISSN: 2213-2600

Few treatment options exist for patients with severe emphysema. We assessed the clinical benefits and safety of lung volume reduction coils (LVRCs) for the treatment of patients with severe emphysema with hyperinflation. In a randomised study, we recruited patients with severe emphysema (aged ?35 years) from three centres in the UK. Using a computer-generated randomisation sequence, we randomly allocated patients in a one-to-one ratio (block sizes of four and stratified by centre) to either LVRC treatment (treatment group) or best medical care (usual care group). The primary endpoint was the difference in response in the St George's Respiratory Questionnaire (SGRQ) between treatment and usual care groups at 90 days after final treatment (by intention-to-treat analysis). The trial is registered, numberNCT01334307. Between Jan 27, 2010, to Oct 25, 2011, we recruited and randomly allocated 47 patients: 23 to treatment and 24 to usual care (23 patients in each group were included in the intention-to-treat analysis). SGRQ response at 90 days after final treatment was greater in the treatment group than it was in the usual care group (between-group difference in change from baseline ?8�36 points [95% CI ?16�24 to ?0�47]; p=0�04). We detected no between-group difference in serious adverse events. Our findings suggest that treatment with endobronchial coils can improve quality of life for patients with severe emphysema and hyperinflation. PneumRx.

Journal article

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