Imperial College London
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ProfessorNickHopkinson

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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Contact

 

n.hopkinson

 
 
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Location

 

Muscle LabSouth BlockRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shah:2013,
author = {Shah, PL and Zoumot, Z and Singh, S and Bicknell, SR and Ross, ET and Quiring, J and Hopkinson, NS and Kemp, SV},
journal = {Lancet},
pages = {233--240},
title = {Endobronchial coils for the treatment of severe emphysema with hyperinflation (RESET): a randomised controlled trial},
url = {http://linkinghub.elsevier.com/retrieve/pii/S221326001370047X},
volume = {1},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Few treatment options exist for patients with severe emphysema. We assessed the clinical benefits and safety of lung volume reduction coils (LVRCs) for the treatment of patients with severe emphysema with hyperinflation. In a randomised study, we recruited patients with severe emphysema (aged ?35 years) from three centres in the UK. Using a computer-generated randomisation sequence, we randomly allocated patients in a one-to-one ratio (block sizes of four and stratified by centre) to either LVRC treatment (treatment group) or best medical care (usual care group). The primary endpoint was the difference in response in the St George's Respiratory Questionnaire (SGRQ) between treatment and usual care groups at 90 days after final treatment (by intention-to-treat analysis). The trial is registered withClinicalTrials.gov, numberNCT01334307. Between Jan 27, 2010, to Oct 25, 2011, we recruited and randomly allocated 47 patients: 23 to treatment and 24 to usual care (23 patients in each group were included in the intention-to-treat analysis). SGRQ response at 90 days after final treatment was greater in the treatment group than it was in the usual care group (between-group difference in change from baseline ?836 points [95% CI ?1624 to ?047]; p=004). We detected no between-group difference in serious adverse events. Our findings suggest that treatment with endobronchial coils can improve quality of life for patients with severe emphysema and hyperinflation. PneumRx.
AU  - Shah,PL
AU  - Zoumot,Z
AU  - Singh,S
AU  - Bicknell,SR
AU  - Ross,ET
AU  - Quiring,J
AU  - Hopkinson,NS
AU  - Kemp,SV
EP  - 240
PY  - 2013///
SN  - 2213-2600
SP  - 233
TI  - Endobronchial coils for the treatment of severe emphysema with hyperinflation (RESET): a randomised controlled trial
T2  - Lancet
UR  - http://linkinghub.elsevier.com/retrieve/pii/S221326001370047X
VL  - 1
ER  -
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