Imperial College London
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Dr Nicolas Newell

Faculty of Engineering, Department of Bioengineering

Lecturer
 
 
 
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Contact

 

n.newell09 Website

 
 
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Location

 

U501aSir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Caldeira:2022:10.1016/j.jmbbm.2022.105150,
author = {Caldeira, J and Celiz, A and Newell, N},
doi = {10.1016/j.jmbbm.2022.105150},
journal = {Journal of the Mechanical Behavior of Biomedical Materials},
pages = {105150--105150},
title = {A biomechanical testing method to assess tissue adhesives for annulus closure},
url = {http://dx.doi.org/10.1016/j.jmbbm.2022.105150},
volume = {129},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Intervertebral disc (IVD) degeneration has been linked to Low Back Pain (LBP) which affects over 80% of the population ranking first in terms of disability worldwide. Degeneration progresses with age and is often accompanied by annulus fibrosus (AF) tearing and nucleus pulposus (NP) herniation. Existing therapies fail to restore IVD function and may worsen AF defects, increasing the risk of reherniation in nearly 30% of patients. Current AF closure options are ineffective, presenting biological or mechanical limitations. Bioadhesives have potential use in this area, however methods to assess performance are limited. Herein, we propose a biomechanical testing method to assess bioadhesives’ capacity to seal AF tears.Two candidate bioadhesives to seal AF tears were evaluated; a tough hydrogel adhesive, and a cyanoacrylate-based glue. The adhesion energy at the interface between bovine discs and the tough hydrogel adhesive was quantified using a peel test (n=4). An experimental method to measure the burst pressure of IVDs was then developed. This method was used to quantify the burst pressure of intact (n=7), injured (AF punctured with a 21G needle; n=7), and sealed IVDs (after applying either the tough hydrogel adhesive patch as a sealant; n=5, or the cyanoacrylate-based glue over the AF tear; n=6).The tough adhesive yielded a strong adhesion energy of 239±49J/m2 during the peel tests. A maximum pressure of 13.2±3.8MPa was observed for intact discs in the burst pressure tests, which reduced by 61.4% to 5.1±1.5MPa in the injured IVDs (p<0.01)). Application of a cyanoacrylate-based glue to injured IVDs did not recover the burst pressure with statistical significance, however, application of the tough adhesive to injured IVDs, restored burst pressure to 12.3±4.5MPa, which was not significantly different to the intact burst pressures.In this study, a simple biomechanical method to assess the performance of bioadhesives to
AU  - Caldeira,J
AU  - Celiz,A
AU  - Newell,N
DO  - 10.1016/j.jmbbm.2022.105150
EP  - 105150
PY  - 2022///
SN  - 1751-6161
SP  - 105150
TI  - A biomechanical testing method to assess tissue adhesives for annulus closure
T2  - Journal of the Mechanical Behavior of Biomedical Materials
UR  - http://dx.doi.org/10.1016/j.jmbbm.2022.105150
UR  - https://www.sciencedirect.com/science/article/pii/S175161612200073X?via%3Dihub
UR  - http://hdl.handle.net/10044/1/95256
VL  - 129
ER  -
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