Imperial College London
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Dr Nicolas Newell

Faculty of Engineering, Department of Bioengineering

Lecturer
 
 
 
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Contact

 

n.newell09 Website

 
 
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Location

 

U501aSir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tavana:2024:10.1016/j.jbiomech.2023.111915,
author = {Tavana, S and Shek, C and Rahman, T and Baxan, N and Newell, N},
doi = {10.1016/j.jbiomech.2023.111915},
journal = {Journal of Biomechanics},
title = {The influence of geometry on intervertebral disc stiffness},
url = {http://dx.doi.org/10.1016/j.jbiomech.2023.111915},
volume = {163},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Geometry plays an important role in intervertebral disc (IVD) mechanics. Previous computational studies have found a link between IVD geometry and stiffness. However, few experimental studies have investigated this link, possibly due to difficulties in non-destructively quantifying internal geometric features. Recent advances in ultra-high resolution MRI provides the opportunity to visualise IVD features in unprecedented detail. This study aimed to quantify 3D human IVD geometries using 9.4 T MRIs and to investigate correlations between geometric variations and IVD stiffness. Thirty human lumbar motion segments (fourteen non-degenerate and sixteen degenerate) were scanned using a 9.4 T MRI and geometric parameters were measured. A 1kN compressive load was applied to each motion segment and stiffness was calculated. Degeneration caused a reduction (p < 0.05) in IVD height, a decreased nucleus-annulus area ratio, and a 1.6 ± 3.0 mm inward collapse of the inner annulus. The IVD height, anteroposterior (AP) width, lateral width, cross-sectional area, nucleus-annulus boundary curvature, and nucleus-annulus area ratio had a significant (p < 0.05) influence on IVD stiffness. Linear relationships (p < 0.05, r > 0.47) were observed between these geometric features and IVD compressive stiffness and a multivariate regression model was generated to enable stiffness to be predicted from features observable on clinical imaging (stiffness, N/mm = 6062 - (61.2 × AP width, mm) - (169.2 × IVD height, mm)). This study advances our understanding of disc structure-function relationships and how these change with degeneration, which can be used to both generate and validate more realistic computational models.
AU  - Tavana,S
AU  - Shek,C
AU  - Rahman,T
AU  - Baxan,N
AU  - Newell,N
DO  - 10.1016/j.jbiomech.2023.111915
PY  - 2024///
SN  - 0021-9290
TI  - The influence of geometry on intervertebral disc stiffness
T2  - Journal of Biomechanics
UR  - http://dx.doi.org/10.1016/j.jbiomech.2023.111915
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38233311
UR  - https://www.sciencedirect.com/science/article/pii/S0021929023004864
UR  - http://hdl.handle.net/10044/1/109298
VL  - 163
ER  -
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