Publications
487 results found
Connolly SJ, Camm AJ, Halperin JL, et al., 2011, Dronedarone in High-Risk Permanent Atrial Fibrillation, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 365, Pages: 2268-2276, ISSN: 0028-4793
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- Citations: 433
Lyon AR, Nikolaev VO, Miragoli M, et al., 2011, Plasticity of Surface Structures and Beta 2-adrenergic Receptor Localization in Failing Ventricular Cardiomyocytes During Recovery From Heart Failure, CIRCULATION, Vol: 124, ISSN: 0009-7322
Lim PB, Malcolme-Lawes LC, Stuber T, et al., 2011, Stimulation of the Intrinsic Cardiac Autonomic Nervous System Results in a Gradient of Fibrillatory Cycle Length Shortening Across the Atria During Atrial Fibrillation in Humans, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 22, Pages: 1224-1231, ISSN: 1045-3873
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- Citations: 20
Ng FS, Cooper SA, Chowdhury RA, et al., 2011, Short-term enhancement of gap junctional coupling during early myocardial infarction modifies late susceptibility to ventricular arrhythmias, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 797-797, ISSN: 0195-668X
Lim PB, Malcolme-Lawes LC, Stuber T, et al., 2011, Intrinsic Cardiac Autonomic Stimulation Induces Pulmonary Vein Ectopy and Triggers Atrial Fibrillation in Humans, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 22, Pages: 638-646, ISSN: 1045-3873
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- Citations: 52
Lyon AR, Bannister ML, Collins T, et al., 2011, SERCA2a Gene Transfer Decreases Sarcoplasmic Reticulum Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 4, Pages: 362-372, ISSN: 1941-3149
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- Citations: 135
Kyriacou A, Pabari P, Willson K, et al., 2011, EVALUATION OF THE IMPACT OF AV DELAY VARIATION ON THE ACUTE MECHANOENERGETIC EFFICIENCY OF CARDIAC RESYNCHRONISATION THERAPY AND ASSESSMENT OF PERFORMANCE OF NON-INVASIVE VS INVASIVE HAEMODYNAMIC OPTIMISATION, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A51-A52, ISSN: 1355-6037
Whinnett ZI, Nott G, Davies JER, et al., 2011, Maximizing Efficiency of Alternation Algorithms for Hemodynamic Optimization of the AV Delay of Cardiac Resynchronization Therapy, PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 34, Pages: 217-225, ISSN: 0147-8389
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- Citations: 18
Duckers HJ, Houtgraaf J, Hehrlein C, et al., 2011, Final results of a phase IIa, randomised, open-label trial to evaluate the percutaneous intramyocardial transplantation of autologous skeletal myoblasts in congestive heart failure patients: the SEISMIC trial, EUROINTERVENTION, Vol: 6, Pages: 805-812, ISSN: 1774-024X
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- Citations: 76
Hall MCS, Kirubakaran S, Choudhury R, et al., 2010, Effects of angiotensin receptor blockade on atrial electrical remodelling and the 'second factor' in a goat burst-paced model of atrial fibrillation, JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, Vol: 11, Pages: 222-233, ISSN: 1470-3203
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- Citations: 7
Ng FS, Owusu-Agyei AA, Chang ETY, et al., 2010, ZP1210, a Novel Gap Junction Modulator, Attenuates Conduction Slowing and Prevents Cx43 Dephosphorylation During Metabolic Stress, American Heart Association (AHA) Scientific Sessions 2010, Pages: A13633-A13633
Vecht JA, Saso S, Rao C, et al., 2010, Atrial septal defect closure is associated with a reduced prevalence of atrial tachyarrhythmia in the short to medium term: a systematic review and meta-analysis, HEART, Vol: 96, Pages: 1789-1797, ISSN: 1355-6037
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- Citations: 53
Hussain W, Patel PM, Chowdhury RA, et al., 2010, The Renin-Angiotensin System Mediates the Effects of Stretch on Conduction Velocity, Connexin43 Expression, and Redistribution in Intact Ventricle, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 21, Pages: 1276-1283, ISSN: 1045-3873
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- Citations: 18
Kojodjojo P, O'Neill MD, Lim PB, et al., 2010, Pulmonary venous isolation by antral ablation with a large cryoballoon for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and non-randomised comparison with pulmonary venous isolation by radiofrequency ablation, Heart, Vol: 96, Pages: 1379-1384, ISSN: 1468-201X
Background To prevent atrial fibrillation (AF) recurrenceafter catheter ablation, pulmonary venous isolation (PVI)at an antral level is more effective than segmental ostialablation. Cryoablation around the pulmonary venous (PV)ostia for AF therapy is potentially safer compared toradiofrequency ablation (RFA). The aim of this study wasto investigate the efficacy of a strategy using a largecryoablation balloon to perform antral cryoablation with‘touch-up’ ostial cryoablation for PVI in patients withparoxysmal and persistent AF.Methods Paroxysmal and persistent AF patientsundergoing their first left atrial ablation were recruited.After cryoballoon therapy, each PV was assessed forisolation and if necessary, treated with focal ostialcryoablation until PVI was achieved. Follow-up withHolter monitoring was performed. Clinical outcomes ofthe cryoablation protocol were compared, withconsecutive patients undergoing PVI by RFA.Results 124 consecutive patients underwentcryoablation. 77% of paroxysmal and 48% of persistentAF subjects were free from AF at 12 months aftera single procedure. Over the same time period, 53consecutive paroxysmal AF subjects underwent PVI withRFA and at 12 months, 72% were free from AF at12 months (p¼NS). There were too few persistent AFsubjects (n¼8) undergoing solely PVI by RFA asa comparison group. Procedural and fluoroscopic timesduring cryoablation were significantly shorter than RFA.Conclusions PV isolation can be achieved in less than2 h by a simple cryoablation protocol with excellentresults after a single intervention, particularly forparoxysmal AF.
Ng FS, Shadi IT, Peters NS, et al., 2010, Ivabradine reduces the incidence of reperfusion ventricular fibrillation following regional ischaemia: insights into anti-arrhythmic protective effect from optical mapping, European Society of Cardiology (ESC), Pages: 1043-1043
Sacher F, Wright M, Tedrow UB, et al., 2010, Wolff-Parkinson-White ablation after a prior failure: a 7-year multicentre experience, EUROPACE, Vol: 12, Pages: 835-841, ISSN: 1099-5129
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- Citations: 39
Ng FS, Lyon AR, Shadi IT, et al., 2010, Moderate gap junctional uncoupling with carbenoxolone slows conduction and increases vulnerability to ventricular arrhythmias—an optical mapping study, 6th Annual Congress of the European Cardiac Arrhythmia Society (April 2010), Pages: 234-234
It is uncertain whether moderate conductionslowing through gap junctional uncoupling on its own, inthe absence of action potential or structural changes, issufficient to be pro-arrhythmic. We used optical mapping:(1) to study the effects of carbenoxolone (CBX), a gapjunction uncoupler, on conduction velocity and actionpotential duration and (2) to assess the effects of moderateconduction slowing and gap junctional uncoupling onarrhythmia vulnerability in structurally normal hearts.Methods: Rat hearts (n = 12) were perfused on aLangendorff apparatus, loaded with a voltage-sensitivedye (RH237) and perfused with an excitation–contractionuncoupler (10 μM blebbistatin). Transmembrane voltagetransients were recorded using a 256-photodiode array.Hearts were then perfused with 30 μM CBX (n=6) orcontrol (n=6) for 30 min and epicardial activation mappedevery 2 min during ventricular pacing. Subsequently, heartswere subjected to programmed ventricular stimulation andassigned an inducibility quotient depending on ease ofarrhythmia inducibility. Results: CBX slowed conductionvelocity (conduction velocity index: baseline 100%, CBX70±2%, P<0.01), with no change in control hearts after30 min (baseline 100%, controls 98±3%, P=NS). CBX didnot affect action potential duration (APD90: baseline 90±3 ms, CBX 94±5 ms, P=NS). Inducibility of ventriculararrhythmias was increased in CBX hearts compared withcontrol hearts (inducibility quotient: CBX 5.0±1.0, control2.5±1.0, P<0.05). Conclusions: Gap junctional uncouplingwith CBX produced a 30% reduction in conductionvelocity without changes in action potential duration andresulted in increased arrhythmia vulnerability. These results suggest that moderate conduction slowing produced by gap junctional uncoupling in isolation, i.e. in the absence of changes in action potential duration or structural abnormalities, is sufficient to increase susceptibility to ventricular arrhythmias.
Ng FS, Lyon AR, Shadi IT, et al., 2010, Modulation of gap junctional coupling as an antiarrhythmic strategy to prevent reperfusion ventricular arrhythmias, 6th Congress of the European Cardiac Arrhythmia Society, Publisher: Springer Verlag, Pages: 173-174, ISSN: 1572-8595
Dib N, Menasche P, Bartunek JJ, et al., 2010, Recommendations for successful training on methods of delivery of biologics for cardiac regeneration: a report of the International Society for Cardiovascular Translational Research., JACC Cardiovasc Interv, Vol: 3, Pages: 265-275
The field of myocardial regeneration (angiogenesis and myogenesis) might prove to play an important role in the future management of cardiovascular disease. Stem cells are currently undergoing testing in Phase I and Phase II clinical trials. Methods of delivery will affect the outcome of such therapies, perhaps significantly. This document provides suggested guidance in 4 methods of delivery: endocardial, intracoronary, coronary sinus, and epicardial.
Segal OR, Chow AWC, Peters NS, et al., 2010, Mechanisms that initiate ventricular tachycardia in the infarcted human heart, HEART RHYTHM, Vol: 7, Pages: 57-64, ISSN: 1547-5271
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- Citations: 22
Karim R, Juli C, Malcolme-Lawes L, et al., 2010, Automatic Segmentation of Left Atrial Geometry from Contrast-Enhanced Magnetic Resonance Images Using a Probabilistic Atlas, 1st International Workshop on Statistical Atlases and Computational Models of the Heart, Publisher: SPRINGER-VERLAG BERLIN, Pages: 134-+, ISSN: 0302-9743
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- Citations: 10
Salukhe TV, Malcolme-Lawes L, Kojodjojo P, et al., 2010, Traditional Electrophysiological Mapping, CARDIAC ELECTROPHYSIOLOGY METHODS AND MODELS, Editors: Sigg, Laizzo, Xiao, He, Publisher: SPRINGER, Pages: 375-393, ISBN: 978-1-4419-6657-5
Linton NWF, Koa-Wing M, Francis DP, et al., 2009, Cardiac ripple mapping: A novel three-dimensional visualization method for use with electroanatomic mapping of cardiac arrhythmias, HEART RHYTHM, Vol: 6, Pages: 1754-1762, ISSN: 1547-5271
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- Citations: 50
Koa-Wing M, Kojodjojo P, Malcolme-Lawes LC, et al., 2009, Robotically Assisted Ablation Produces More Rapid and Greater Signal Attenuation Than Manual Ablation, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 20, Pages: 1398-1404, ISSN: 1045-3873
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- Citations: 15
Thorning C, Hamady M, Liaw JVP, et al., 2009, CT evaluation of pulmonary venous anatomy variation in patients undergoing catheter ablation for atrial fibrillation, CLINICAL IMAGING, Vol: 35, Pages: 1-9, ISSN: 0899-7071
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- Citations: 34
Dhillon PS, Gray R, Kojodjojo P, et al., 2009, The Relationship Between Gap Junction Conductance and Conduction Velocity in Intact Myocardium, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S621-S621, ISSN: 0009-7322
Scharf C, Boersma L, Davies W, et al., 2009, Ablation of Persistent Atrial Fibrillation Using Multielectrode Catheters and Duty-Cycled Radiofrequency Energy, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 54, Pages: 1450-1456, ISSN: 0735-1097
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- Citations: 79
Koa-Wing M, Linton NWF, Kojodjojo P, et al., 2009, Robotic Catheter Ablation of Ventricular Tachycardia in a Patient with Congenital Heart Disease and Rastelli Repair, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 20, Pages: 1163-1166, ISSN: 1045-3873
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- Citations: 7
Vecht R, Gatzoulis MA, Peters NS, 2009, ECG Diagnosis in Clinical Practice (ISBN 978-1-84800-311-8), London, Publisher: Springer
Kontogeorgis A, Li X, Kang EY, et al., 2008, Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 295, Pages: H1905-H1916, ISSN: 0363-6135
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- Citations: 11
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