Imperial College London
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ProfessorNicholasPeters

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiac Electrophysiology
 
 
 
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Contact

 

+44 (0)20 7594 1880n.peters Website

 
 
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Assistant

 

Ms Anastasija Schmidt +44 (0)20 7594 1880

 
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Location

 

NHLI officesSir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ciaccio:2017:10.1016/j.compbiomed.2017.02.008,
author = {Ciaccio, EJ and Biviano, AB and Wan, EY and Peters, NS and Garan, H},
doi = {10.1016/j.compbiomed.2017.02.008},
journal = {Computers in Biology and Medicine},
pages = {166--181},
title = {Development of an automaton model of rotational activity driving atrial fibrillation},
url = {http://dx.doi.org/10.1016/j.compbiomed.2017.02.008},
volume = {83},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Atrial fibrillation (AF) is difficult to treat effectively, owing to uncertainty in where to best ablate to eliminate arrhythmogenic substrate. A model providing insight into the electrical activation events would be useful to guide catheter ablation strategy.Method:A two-dimensional, 576×576 node automaton was developed to simulate atrial electrical activity. The substrate field was altered by the presence of differing refractory period at varying locations. Fibrosis was added in the form of short, randomly positioned lines of conduction block. Larger areas of block were used to simulate ablation lesions. Anisotropy was imposed in a 2:1 ratio. A premature electrical impulse from one of four grid corners was utilized to initiate activation.Results:Rotational activity was uninducible when refractory patch dimensions were less than 20×20 mm. For larger refractory regions, a single premature stimulus was capable of inducing an average of 1.19±1.10 rotors, which often formed near the patch edges. A maximum of 5 rotors formed when refractory patch dimensions approached the size of the entire left atrial virtual field. Rotors formed along a refractory patch edge, after wavefront arrival was delayed at turning points or due to the presence of a fiber cluster of sufficient size. However, rotational activity could also occur around a large fiber cluster without the need of spatially variable refractoriness. When obstacles to conduction were lacking in size, nascent rotors drifted and either extinguished, or stabilized upon anchoring at a sufficiently large fiber cluster elsewhere in the field. Transient rotors terminated when traversing a region with differing refractory periods, if no obstacle to conduction was present to sufficiently delay wavefront arrival beyond the longest refractory period. Other rotors were annihilated when a nearby rotor with faster spin rate gradually interrupted the activation pathway. Elimination of anchors by removal
AU  - Ciaccio,EJ
AU  - Biviano,AB
AU  - Wan,EY
AU  - Peters,NS
AU  - Garan,H
DO  - 10.1016/j.compbiomed.2017.02.008
EP  - 181
PY  - 2017///
SN  - 0010-4825
SP  - 166
TI  - Development of an automaton model of rotational activity driving atrial fibrillation
T2  - Computers in Biology and Medicine
UR  - http://dx.doi.org/10.1016/j.compbiomed.2017.02.008
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000399862200017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60190
VL  - 83
ER  -
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