Publications
793 results found
Robinson TG, Potter JF, Ford GA, et al., 2010, Effects of antihypertensive treatment after acute stroke in the Continue Or Stop post-Stroke Antihypertensives Collaborative Study (COSSACS): a prospective, randomised, open, blinded-endpoint trial, LANCET NEUROLOGY, Vol: 9, Pages: 767-775, ISSN: 1474-4422
- Author Web Link
- Cite
- Citations: 161
Lindgren P, Eriksson J, Buxton M, et al., 2010, The economic consequences of non-adherence to lipid-lowering therapy: results from the Anglo-Scandinavian-Cardiac Outcomes Trial, INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol: 64, Pages: 1228-1234, ISSN: 1368-5031
- Author Web Link
- Cite
- Citations: 11
Gupta AK, Dahlof B, Sever PS, et al., 2010, Metabolic Syndrome, Independent of Its Components, Is a Risk Factor for Stroke and Death But Not for Coronary Heart Disease Among Hypertensive Patients in the ASCOT-BPLA, Diabetes Care, Vol: 33, Pages: 1647-1651, ISSN: 1935-5548
OBJECTIVE — To evaluate whether in hypertensive patients the risk of cardiovascular diseaseis greater in association with the metabolic syndrome (MetS) or the sum of its individualcomponents.RESEARCH DESIGN AND METHODS — Cox regression analysis models were developedto assess the influence of age, sex, ethnicity, and the individual components of MetS on riskassociated with the MetS (using several definitions) of coronary outcomes, stroke, and all-causemortality.RESULTS — MetS was significantly associated with coronary outcomes, stroke, and all-causemortality after adjusting for age, sex, and ethnicity. However, when the model was furtheradjusted for the individual components, MetS was associated with significantly increased risk ofstroke (hazard ratio 1.34 [95% CI 1.07–1.68]) and all-cause mortality (1.35 [1.16–1.58]) butnot coronary outcomes (fatal coronary heart disease plus nonfatal myocardial infarction 1.16[0.95–1.43] and total coronary events 1.06 [0.91–1.24]).CONCLUSIONS — MetS, independent of its individual components, is associated withincreased risk of stroke and all-cause mortality but not coronary outcomes.
Manisty C, Mayet J, Tapp RJ, et al., 2010, Wave Reflection Predicts Cardiovascular Events in Hypertensive Individuals Independent of Blood Pressure and Other Cardiovascular Risk Factors An ASCOT (Anglo-Scandinavian Cardiac Outcome Trial) Substudy, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 56, Pages: 24-30, ISSN: 0735-1097
- Author Web Link
- Cite
- Citations: 82
Jafar TH, Islam M, Hatcher J, et al., 2010, Community based lifestyle intervention for blood pressure reduction in children and young adults in developing country: cluster randomised controlled trial, BMJ, Vol: 340, ISSN: 0959-8138
Objective To assess the effectiveness of a community based lifestyle intervention on blood pressure in children and young adults in a developing country setting.Design Cluster randomised controlled trial.Setting 12 randomly selected geographical census based clusters in Karachi, Pakistan.Participants 4023 people aged 5-39 years.Intervention Three monthly family based home health education delivered by lay health workers.Main outcome measure Change in blood pressure from randomisation to end of follow-up at 2 years.Results Analysed using the intention to treat principle, the change in systolic blood pressure (adjusted for age, sex, and baseline blood pressure) was significant; it increased by 1.5 (95% confidence interval 1.1 to 1.9) mm Hg in the control group and by 0.1 (−0.3 to 0.5) mm Hg in the home health education group (P for difference between groups=0.02). Findings for diastolic blood pressure were similar; the change was 1.5 mm Hg greater in the control group than in the intervention group (P=0.002).Conclusions Simple, family based home health education delivered by trained lay health workers significantly ameliorated the usual increase in blood pressure with age in children and young adults in the general population of Pakistan, a low income developing country. This strategy is potentially feasible for up-scaling within the existing healthcare systems of Indo-Asia.
Ninomiya T, Zoungas S, Neal B, et al., 2010, Efficacy and safety of routine blood pressure lowering in older patients with diabetes: results from the ADVANCE trial, JOURNAL OF HYPERTENSION, Vol: 28, Pages: 1141-1149, ISSN: 0263-6352
- Author Web Link
- Cite
- Citations: 42
Poulter NR, 2010, OPTIMAL EVIDENCE-BASED CARDIOVASCULAR PROTECTION WITH PERINDOPRIL/AMLODIPINE COMBINATION, 20th Annual Meeting of the European-Society-of-Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E611-E612, ISSN: 0263-6352
Robinson T, Bulpitt CJ, Ford GA, et al., 2010, CONTINUE OR STOP POST-STROKE ANTIHYPERTENSIVES COLLABORATIVE STUDY (COSSACS): MAIN RESULTS, 20th Annual Meeting of the European-Society-of-Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E234-E234, ISSN: 0263-6352
- Author Web Link
- Cite
- Citations: 2
Rothwell PM, Howard SC, Dolan E, et al., 2010, Effects of β blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke, LANCET NEUROLOGY, Vol: 9, Pages: 469-480, ISSN: 1474-4422
- Author Web Link
- Cite
- Citations: 524
Tapp RJ, Sharp A, Stanton AV, et al., 2010, Differential Effects of Antihypertensive Treatment on Left Ventricular Diastolic Function An ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) Substudy, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 1875-1881, ISSN: 0735-1097
- Author Web Link
- Cite
- Citations: 38
Rothwell PM, Howard SC, Dolan E, et al., 2010, Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension, LANCET, Vol: 375, Pages: 895-905, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 1261
Poulter NR, Dobson JE, Sever PS, et al., 2010, Elevated Heart Rate in Hypertension A Target for Treatment? Reply, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 931-932, ISSN: 0735-1097
- Author Web Link
- Cite
- Citations: 3
Sharp ASP, Tapp RJ, Thom SAM, et al., 2010, Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 747-752, ISSN: 0195-668X
- Author Web Link
- Cite
- Citations: 155
Gupta AK, Arshad S, Poulter NR, 2010, Compliance, Safety, and Effectiveness of Fixed-Dose Combinations of Antihypertensive Agents A Meta-Analysis, HYPERTENSION, Vol: 55, Pages: 399-407, ISSN: 0194-911X
- Author Web Link
- Cite
- Citations: 493
Shahab L, Mindell J, Poulter NR, et al., 2010, Hypertension and its identification among current, past and never smokers in an English population sample, EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, Vol: 17, Pages: 63-70, ISSN: 1741-8267
- Author Web Link
- Cite
- Citations: 4
Poulter NR, 2010, Combination Therapy in Hypertension, Salop, Publisher: Nova Professional Media
Lindgren P, Eriksson J, Buxton M, et al., 2009, The Economic Consequences of Non-Adherence to Lipid-Lowering Therapy: Results From the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S484-S485, ISSN: 0009-7322
Plutzky J, Poulter NR, Falahati A, et al., 2009, Plasminogen Activator Inhibitor-1 is Reduced by the Once-Daily Human Glucagon-Like Peptide-1 Analog Liraglutide When Used in the Treatment of Type 2 Diabetes, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S397-S397, ISSN: 0009-7322
- Author Web Link
- Cite
- Citations: 4
Jafar TH, Hatcher J, Poulter N, et al., 2009, Community-Based Interventions to Promote Blood Pressure Control in a Developing Country A Cluster Randomized Trial, ANNALS OF INTERNAL MEDICINE, Vol: 151, Pages: 593-W195, ISSN: 0003-4819
- Author Web Link
- Cite
- Citations: 127
Zoungas S, de Galan BE, Ninomiya T, et al., 2009, Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial., Diabetes Care, Vol: 32, Pages: 2068-2074, ISSN: 1935-5548
OBJECTIVE: To assess the magnitude and independence of the effects of routine blood pressure lowering and intensive glucose control on clinical outcomes in patients with long-standing type 2 diabetes. RESEARCH DESIGN AND METHODS: This was a multicenter, factorial randomized trial of perindopril-indapamide versus placebo (double-blind comparison) and intensive glucose control with a gliclazide MR-based regimen (target A1C <or=6.5%) versus standard glucose control (open comparison) in 11,140 participants with type 2 diabetes who participated in the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) trial. Annual event rates and risks of major macrovascular and microvascular events considered jointly and separately, renal events, and death during an average 4.3 years of follow-up were assessed, using Cox proportional hazards models. RESULTS: There was no interaction between the effects of routine blood pressure lowering and intensive glucose control for any of the prespecified clinical outcomes (all P > 0.1): the separate effects of the two interventions for the renal outcomes and death appeared to be additive on the log scale. Compared with neither intervention, combination treatment reduced the risk of new or worsening nephropathy by 33% (95% CI 12-50%, P = 0.005), new onset of macroalbuminuria by 54% (35-68%, P < 0.0001), and new onset of microalbuminuria by 26% (17-34%). Combination treatment was associated with an 18% reduction in the risk of all-cause death (1-32%, P = 0.04). CONCLUSIONS: The effects of routine blood pressure lowering and intensive glucose control were independent of one another. When combined, they produced additional reductions in clinically relevant outcomes.
Manisty C, Mayet J, Tapp RJ, et al., 2009, Atorvastatin Treatment Is Associated With Less Augmentation of the Carotid Pressure Waveform in Hypertension A Substudy of the Anglo- Scandinavian Cardiac Outcome Trial (ASCOT), HYPERTENSION, Vol: 54, Pages: 1009-U136, ISSN: 0194-911X
- Author Web Link
- Cite
- Citations: 38
de Galan BE, Zoungas S, Chalmers J, et al., 2009, Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial, DIABETOLOGIA, Vol: 52, Pages: 2328-2336, ISSN: 0012-186X
- Author Web Link
- Cite
- Citations: 148
Prieto-Merino D, Gupta AK, Dobson J, et al., 2009, ASCORE: an up-to-date cardiovascular risk score for hypertensive patients reflecting contemporary clinical practices developed using the ASCOT trial database, JOURNAL OF HUMAN HYPERTENSION, Vol: 23, Pages: 695-695, ISSN: 0950-9240
Poulter NR, Dobson JE, Sever PS, et al., 2009, Baseline Heart Rate, Antihypertensive Treatment, and Prevention of Cardiovascular Outcomes in ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 54, Pages: 1154-1161, ISSN: 0735-1097
- Author Web Link
- Cite
- Citations: 56
Chalmers J, Marre M, de Galan B, et al., 2009, The efficacy of lowering HbA<sub>1c</sub> with a gliclazide modified release-based intensive glucose lowering regimen in the ADVANCE trial, 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Publisher: SPRINGER, Pages: S354-S354, ISSN: 0012-186X
- Author Web Link
- Cite
- Citations: 2
Plutzky J, Garber A, Toft AD, et al., 2009, Meta-analysis demonstrates that liraglutide, a once-daily human GLP-1 analogue, significantly reduces lipids and other markers of cardiovascular risk in type 2 diabetes, 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Publisher: SPRINGER, Pages: S299-S300, ISSN: 0012-186X
- Author Web Link
- Cite
- Citations: 20
Plutzky J, Garber AJ, Falahati A, et al., 2009, The once-daily human GLP-1 analogue, liraglutide, significantly reduces markers of cardiovascular risk in type 2 diabetes: a meta-analysis of six clinical trials, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 917-917, ISSN: 0195-668X
- Author Web Link
- Cite
- Citations: 14
Ninomiya T, Perkovic V, de Galan BE, et al., 2009, Albuminuria and Kidney Function Independently Predict Cardiovascular and Renal Outcomes in Diabetes, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 20, Pages: 1813-1821, ISSN: 1046-6673
- Author Web Link
- Cite
- Citations: 686
White SL, Perkovic V, Cass A, et al., 2009, Is Low Birth Weight an Antecedent of CKD in Later Life? A Systematic Review of Observational Studies, AMERICAN JOURNAL OF KIDNEY DISEASES, Vol: 54, Pages: 248-261, ISSN: 0272-6386
- Author Web Link
- Cite
- Citations: 331
Kengne A-P, Czernichow S, Huxley R, et al., 2009, Blood Pressure Variables and Cardiovascular Risk New Findings From ADVANCE, 7th International Workshop on Structure and Function of the Vascular System, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 399-404, ISSN: 0194-911X
- Author Web Link
- Cite
- Citations: 62
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.