Imperial College London
Alternate

Professor Neil Poulter

Faculty of Medicine, School of Public Health

Professor of Preventive Cardiovascular Medicine.
 
 
 
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Contact

 

+44 (0)20 7594 3446n.poulter

 
 
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Assistant

 

Mrs Ranjit Rayat +44 (0)20 7594 3445

 
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Location

 

55Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Noordam:2017:10.1136/jmedgenet-2016-104112,
author = {Noordam, R and Sitlani, CM and Avery, CL and Stewart, JD and Gogarten, SM and Wiggins, KL and Trompet, S and Warren, HR and Sun, F and Evans, DS and Li, X and Li, J and Smith, AV and Bis, JC and Brody, JA and Busch, EL and Caulfield, MJ and Chen, Y-DI and Cummings, SR and Cupples, LA and Duan, Q and Franco, OH and Mendez-Giraldez, R and Harris, TB and Heckbert, SR and van, Heemst D and Hofman, A and Floyd, JS and Kors, JA and Launer, LJ and Li, Y and Li-Gao, R and Lange, LA and Lin, HJ and de, Mutsert R and Napier, MD and Newton-Cheh, C and Poulter, N and Reiner, AP and Rice, KM and Roach, J and Rodriguez, CJ and Rosendaal, FR and Sattar, N and Sever, P and Seyerle, AA and Slagboom, PE and Soliman, EZ and Sotoodehnia, N and Stott, DJ and Stumer, T and Taylor, KD and Thornton, TA and Uitterlinden, AG and Wilhelmsen, KC and Wilson, JG and Gudnason, V and Jukema, JW and Laurie, CC and Liu, Y and Mook-Kanamori, DO and Munroe, PB and Rotter, JI and Vasan, RS and Psaty, BM and Stricker, BH a},
doi = {10.1136/jmedgenet-2016-104112},
journal = {JOURNAL OF MEDICAL GENETICS},
pages = {313--323},
title = {A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium},
url = {http://dx.doi.org/10.1136/jmedgenet-2016-104112},
volume = {54},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Increased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbidity and mortality, and can be influenced by the use of various medications, including tricyclic/tetracyclic antidepressants (TCAs). We aim to identify genetic loci that modify the association between TCA use and RR and QT intervals.Methods: and results We conducted race/ethnic-specific genome-wide interaction analyses (with HapMap phase II imputed reference panel imputation) of TCAs and resting RR and QT intervals in cohorts of European (n=45706; n=1417 TCA users), African (n=10235; n=296 TCA users) and Hispanic/Latino (n=13808; n=147 TCA users) ancestry, adjusted for clinical covariates. Among the populations of European ancestry, two genome-wide significant loci were identified for RR interval: rs6737205 in BRE (β=56.3, pinteraction=3.9e−9) and rs9830388 in UBE2E2 (β=25.2, pinteraction=1.7e−8). In Hispanic/Latino cohorts, rs2291477 in TGFBR3 significantly modified the association between TCAs and QT intervals (β=9.3, pinteraction=2.55e−8). In the meta-analyses of the other ethnicities, these loci either were excluded from the meta-analyses (as part of quality control), or their effects did not reach the level of nominal statistical significance (pinteraction>0.05). No new variants were identified in these ethnicities. No additional loci were identified after inverse-variance-weighted meta-analysis of the three ancestries.Conclusions: Among Europeans, TCA interactions with variants in BRE and UBE2E2 were identified in relation to RR intervals. Among Hispanic/Latinos, variants in TGFBR3 modified the relation between TCAs and QT intervals. Future studies are required to confirm our results.
AU  - Noordam,R
AU  - Sitlani,CM
AU  - Avery,CL
AU  - Stewart,JD
AU  - Gogarten,SM
AU  - Wiggins,KL
AU  - Trompet,S
AU  - Warren,HR
AU  - Sun,F
AU  - Evans,DS
AU  - Li,X
AU  - Li,J
AU  - Smith,AV
AU  - Bis,JC
AU  - Brody,JA
AU  - Busch,EL
AU  - Caulfield,MJ
AU  - Chen,Y-DI
AU  - Cummings,SR
AU  - Cupples,LA
AU  - Duan,Q
AU  - Franco,OH
AU  - Mendez-Giraldez,R
AU  - Harris,TB
AU  - Heckbert,SR
AU  - van,Heemst D
AU  - Hofman,A
AU  - Floyd,JS
AU  - Kors,JA
AU  - Launer,LJ
AU  - Li,Y
AU  - Li-Gao,R
AU  - Lange,LA
AU  - Lin,HJ
AU  - de,Mutsert R
AU  - Napier,MD
AU  - Newton-Cheh,C
AU  - Poulter,N
AU  - Reiner,AP
AU  - Rice,KM
AU  - Roach,J
AU  - Rodriguez,CJ
AU  - Rosendaal,FR
AU  - Sattar,N
AU  - Sever,P
AU  - Seyerle,AA
AU  - Slagboom,PE
AU  - Soliman,EZ
AU  - Sotoodehnia,N
AU  - Stott,DJ
AU  - Stumer,T
AU  - Taylor,KD
AU  - Thornton,TA
AU  - Uitterlinden,AG
AU  - Wilhelmsen,KC
AU  - Wilson,JG
AU  - Gudnason,V
AU  - Jukema,JW
AU  - Laurie,CC
AU  - Liu,Y
AU  - Mook-Kanamori,DO
AU  - Munroe,PB
AU  - Rotter,JI
AU  - Vasan,RS
AU  - Psaty,BM
AU  - Stricker,BH
AU  - Whitsel,EA
DO  - 10.1136/jmedgenet-2016-104112
EP  - 323
PY  - 2017///
SN  - 0022-2593
SP  - 313
TI  - A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium
T2  - JOURNAL OF MEDICAL GENETICS
UR  - http://dx.doi.org/10.1136/jmedgenet-2016-104112
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000400022200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48713
VL  - 54
ER  -
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