Imperial College London
Alternate

Professor Neil Poulter

Faculty of Medicine, School of Public Health

Professor of Preventive Cardiovascular Medicine.
 
 
 
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Contact

 

+44 (0)20 7594 3446n.poulter

 
 
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Assistant

 

Mrs Ranjit Rayat +44 (0)20 7594 3445

 
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Location

 

55Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mohammedi:2018:10.1038/s41387-017-0012-y,
author = {Mohammedi, K and Chalmers, J and Herrington, W and Li, Q and Mancia, G and Marre, M and Poulter, N and Rodgers, A and Williams, B and Perkovic, V and Coresh, J and Woodward, M},
doi = {10.1038/s41387-017-0012-y},
journal = {Nutrition & Diabetes},
title = {Associations between body mass index and the risk of renal events in patients with type 2 diabetes},
url = {http://dx.doi.org/10.1038/s41387-017-0012-y},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND/OBJECTIVES: We aimed to evaluate the relationship between BMI and the risk of renal disease in patients with type 2 diabetes in the Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation (ADVANCE) study. SUBJECTS/METHODS: Participants were divided into six baseline BMI categories: <18.5 (underweight, n = 58); ≥18.5 to <25 (normal, n = 2894); ≥25 to <30 (overweight, n = 4340); ≥30 to <35 (obesity grade 1, n = 2265); ≥35 to <40 (obesity grade 2, n = 744); and ≥40 kg/m2(obesity grade 3, n = 294); those underweight were excluded. The composite outcome "major renal event" was defined as development of new macroalbuminuria, doubling of creatinine, end stage renal disease, or renal death. These outcomes and development of new microalbuminuria were considered individually as secondary endpoints. RESULTS: During 5-years of follow-up, major renal events occurred in 487 (4.6%) patients. The risk increased with higher BMI. Multivariable-adjusted HRs (95% CIs), compared to normal weight, were: 0.91 (0.72-1.15) for overweight; 1.03 (0.77-1.37) for obesity grade 1; 1.42 (0.98-2.07) for grade 2; and 2.16 (1.34-3.48) for grade 3 (p for trend = 0.006). These findings were similar across subgroups by randomised interventions (intensive versus standard glucose control and perindopril-indapamide versus placebo). Every additional unit of BMI over 25 kg/m2increased the risk of major renal events by 4 (1-6)%. Comparable results were observed with the risk of secondary endpoints. CONCLUSIONS: Higher BMI is an independent predictor of major renal events in patients with type 2 diabetes. Our findings encourage weight loss to improve nephroprotection in these patients.
AU  - Mohammedi,K
AU  - Chalmers,J
AU  - Herrington,W
AU  - Li,Q
AU  - Mancia,G
AU  - Marre,M
AU  - Poulter,N
AU  - Rodgers,A
AU  - Williams,B
AU  - Perkovic,V
AU  - Coresh,J
AU  - Woodward,M
DO  - 10.1038/s41387-017-0012-y
PY  - 2018///
SN  - 2044-4052
TI  - Associations between body mass index and the risk of renal events in patients with type 2 diabetes
T2  - Nutrition & Diabetes
UR  - http://dx.doi.org/10.1038/s41387-017-0012-y
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29343817
UR  - http://hdl.handle.net/10044/1/58265
VL  - 8
ER  -
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