Publications
366 results found
Mourkioti F, Rosenthal N, 2008, NF-kappa B signaling in skeletal muscle: prospects for intervention in muscle diseases, JOURNAL OF MOLECULAR MEDICINE-JMM, Vol: 86, Pages: 747-759, ISSN: 0941-0198
Muscle remodeling is an important physiological process that promotes adaptive changes in cytoarchitecture and protein composition after exercise, aging, or disease conditions. Numerous transcription factors have been reported to regulate skeletal muscle homeostasis. NF-κB is a major pleiotropic transcription factor modulating immune, inflammatory, cell survival, and proliferating responses; however, its role in muscle development, physiology, and disease has just started to be elucidated. The current review article aims to summarize the literature on the role of NF-κB signaling in skeletal muscle pathophysiology, investigated over the last years using in vitro and more recently in vivo systems. Understanding the exact role of NF-κB in muscle cells will allow better therapeutic manipulations in the setting of human muscle diseases.
Klimanskaya I, Rosenthal N, Lanza R, 2008, Derive and conquer: sourcing and differentiating stem cells for therapeutic applications, NATURE REVIEWS DRUG DISCOVERY, Vol: 7, Pages: 131-142, ISSN: 1474-1776
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- Citations: 128
Lara-Pezzi E, Felkin LE, Sarathchandra P, et al., 2008, Follistatin gene expression in heart failure and myocardial recovery following LVAD combination therapy, 28th Annual Meeting of the International-Society-for-Heart-and-Lung-Transplantation, Publisher: ELSEVIER SCIENCE INC, Pages: S220-S220, ISSN: 1053-2498
Hancock JM, Schofield PN, Chandras C, et al., 2008, CASIMIR: Coordination and Sustainability of International Mouse Informatics Resources, 8th IEEE International Conference on Bioinformatics and Bioengineering, Publisher: IEEE, Pages: 382-+, ISSN: 2471-7819
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- Citations: 3
Lara-Pezzi E, Winn N, Paul A, et al., 2007, A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration, The Journal of Cell Biology, Vol: 179, Pages: 1205-1218, ISSN: 0021-9525
The calcium-activated phosphatase calcineurin (Cn) transduces physiological signals through intracellular pathways to influence the expression of specific genes. Here, we characterize a naturally occurring splicing variant of the CnAβ catalytic subunit (CnAβ1) in which the autoinhibitory domain that controls enzyme activation is replaced with a unique C-terminal region. The CnAβ1 enzyme is constitutively active and dephosphorylates its NFAT target in a cyclosporine-resistant manner. CnAβ1 is highly expressed in proliferating myoblasts and regenerating skeletal muscle fibers. In myoblasts, CnAβ1 knockdown activates FoxO-regulated genes, reduces proliferation, and induces myoblast differentiation. Conversely, CnAβ1 overexpression inhibits FoxO and prevents myotube atrophy. Supplemental CnAβ1 transgene expression in skeletal muscle leads to enhanced regeneration, reduced scar formation, and accelerated resolution of inflammation. This unique mode of action distinguishes the CnAβ1 isoform as a candidate for interventional strategies in muscle wasting treatment.
Rosenthal N, Winn N, Santini MP, 2007, IGF-1, Muscle Progenitors, and Heart Failure, Cardiovascular Regeneration and Stem Cell Therapy, Pages: 149-158, ISBN: 9781405148429
Lara-Pezzi E, Felkin LE, Sarathchandra P, et al., 2007, A potentially novel role of the follistatin-activin pathway in heart failure and myocardial recovery following LVAD combination therapy, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 541-541, ISSN: 0009-7322
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- Citations: 1
Pelosi M, Marampon F, Zani BM, et al., 2007, ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program, MOLECULAR AND CELLULAR BIOLOGY, Vol: 27, Pages: 6163-6176, ISSN: 0270-7306
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- Citations: 40
Rosenthal N, Brown S, 2007, The mouse ascending: perspectives for human-disease models, NATURE CELL BIOLOGY, Vol: 9, Pages: 993-999, ISSN: 1465-7392
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- Citations: 273
Reuveni E, Carola V, Al Banchaabouchi M, et al., 2007, Phenostat: visualization and statistical tool for analysis of phenotyping data, MAMMALIAN GENOME, Vol: 18, Pages: 677-681, ISSN: 0938-8990
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- Citations: 1
Lara-Pezzi E, Felkin LE, Birks E, et al., 2007, Myocardial follistatin gene expression is elevated in heart failure and decreases following recovery, Publisher: OXFORD UNIV PRESS, Pages: 787-787, ISSN: 0195-668X
Batten P, Rosenthal NA, Yacoub MH, 2007, Immune response to stem cells and strategies to induce tolerance, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 362, Pages: 1343-1356, ISSN: 0962-8436
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- Citations: 14
Cravo R, Castillo H, Simoes-Costa M, et al., 2007, Regulatory enhancers in the RALDH2 gene, 66th SDB Annual Meeting/8th SMBD Annual Meeting/3rd LASDB International Meeting, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: 349-349, ISSN: 0012-1606
Lara-Pezzi E, Felkin LE, Birks E, et al., 2007, Follistatin gene expression is elevated in heart failure and decreases following recovery, 19th World Congress of the International-Society-for-Heart-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: S147-S147, ISSN: 0022-2828
Pelosi L, Giacinti C, Nardis C, et al., 2007, Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines, FASEB JOURNAL, Vol: 21, Pages: 1393-1402, ISSN: 0892-6638
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- Citations: 208
Semenova E, Werner S, Koegel H, et al., 2007, Overexpression of mlGF-1 in proliferating keratinocytes accelerates hair follicle formation and cycling and improves wound healing in mice, 68th Annual Meeting of the Society-for-Investigative-Dermatology, Publisher: NATURE PUBLISHING GROUP, Pages: S106-S106, ISSN: 0022-202X
Mirabeau O, Perlas E, Severini C, et al., 2007, Identification of novel peptide hormones in the human proteome by hidden Markov model screening, GENOME RESEARCH, Vol: 17, Pages: 320-327, ISSN: 1088-9051
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- Citations: 196
Mourkioti F, Kratsios P, Luedde T, et al., 2007, Erratum: Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration (Journal of Clinical Investigation (2006) 116 (2945-2954) DOI:10.1172/JCI28721), Journal of Clinical Investigation, Vol: 117, ISSN: 0021-9738
Santini MP, Tsao L, Monassier L, et al., 2007, Enhancing repair of the mammalian heart, Circ Research, Vol: 100, Pages: 1732-1740
Rosenthal N, Schneider MD, Chien KR, et al., 2006, Discussion, Pages: 267-271, ISSN: 1528-2511
Rosenthal N, Kranias L, Leinwand L, et al., 2006, Discussion, Pages: 172-175, ISSN: 1528-2511
Muslin A, Komuro I, Sugden P, et al., 2006, Discussion, Pages: 31-40, ISSN: 1528-2511
Izumo S, Muslin A, McKinsey T, et al., 2006, Discussion, Pages: 126-131, ISSN: 1528-2511
Leinwand L, Field LJ, Nemer M, et al., 2006, Discussion, Pages: 208-213, ISSN: 1528-2511
Leinwand L, Olson EN, Rosenthal N, et al., 2006, Discussion, Pages: 13-19, ISSN: 1528-2511
Katz AM, Nemer M, Olson EN, et al., 2006, Discussion, Pages: 68-72, ISSN: 1528-2511
Olson EN, Shetty SS, Simpson PC, et al., 2006, Final general discussion, Pages: 272-276, ISSN: 1528-2511
Rosenthal N, Muslin A, Sugden P, et al., 2006, Discussion, Pages: 111-117, ISSN: 1528-2511
Marks AR, Doevendans PA, Muslin A, et al., 2006, Discussion, Pages: 51-57, ISSN: 1528-2511
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