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BibTex format

@inbook{Rosenthal:2019:10.4324/9780429050329-28,
author = {Rosenthal, N and Kress, M and Gruss, P and Khoury, G},
booktitle = {Biotechnology and Biological Frontiers},
doi = {10.4324/9780429050329-28},
pages = {351--364},
title = {BK Viral enhancer element and a human cellular homolog},
url = {http://dx.doi.org/10.4324/9780429050329-28},
year = {2019}
}

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TY  - CHAP
AB  - Identification of elements that control the initiation of transcription is a crucial step in understanding the regulation of eukaryotic gene expression. Approaches to the problem of transcriptional control with animal viruses as a model system have recently uncovered transcriptional regulatory elements, called enhancers. This chapter utilizes the human papovavirus BKV as a viral model of eukaryotic transcriptional control. The 68-bp BKV triplication functions as an enhancer element for gene expression in a number of cell types without a pronounced host cell preference. To investigate the possibility that viral enhancers may have cellular homologs, we screened a human genomic λ library for sequences related to the BKV tandem triplication with the 216-bp BKV Hae III fragment as a probe. The sequence length and arrangement of the human genomic tandem repeats is different from that of the BKV enhancer, certain similarities such as the core region and the glycoprotein-rich hexanucleotides are impressive.
AU  - Rosenthal,N
AU  - Kress,M
AU  - Gruss,P
AU  - Khoury,G
DO  - 10.4324/9780429050329-28
EP  - 364
PY  - 2019///
SN  - 9780367020460
SP  - 351
TI  - BK Viral enhancer element and a human cellular homolog
T1  - Biotechnology and Biological Frontiers
UR  - http://dx.doi.org/10.4324/9780429050329-28
ER  -

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