Imperial College London

DrNeloferSyed

Faculty of MedicineDepartment of Brain Sciences

Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 5292n.syed

 
 
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Location

 

E506Burlington DanesHammersmith Campus

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Summary

 

Summary

Dr Nelofer Syed obtained her PhD from Imperial College under the direction of Professor Margaret Dallman in 2003. Her PhD training was in the field of molecular immunology and involved the generation of transgenic mouse models to conditionally silence genes of the immune system. After completing her PhD training she persued her interests in translational cancer epigenetics by joining the laboratory of Dr Timothy Crook at the Ludwig Institute of Cancer Research, London. Her main focus here centred around identifying cancer specific epigenetic changes that could be targets for therapy. She continued her research at the Institute of Cancer Research, London, where she played a key role in identifying a gene (Tip60) having a critical involvement in breast cancer development.

In 2008 she returned to Imperial College/Charing Cross Hospital NHS Trust to set up a molecular neuro-oncology laboratory (John Fulcher Molecular Lab) funded by the Brain Tumour Research Campaign (BTRC) to investigate various aspects of brain tumour biology, genetics and epigenetics. Her work has already generated novel data on deranged amino acid metabolism that she hopes will form the basis of a phase 2 clinical trial of arginine depletion as a novel therapeutic strategy for brain tumours. In 2011 she was appointed research lecturer at Imperial College/Charing Cross Hospital NHS Trust and continues to direct her research programme of translational research in brain tumours with a particular emphasis on identifying deranged metabolic pathways to identify novel therapeutic strategies. Her group consists of two senior post-doctoral scientists (Dr Fernando Abaitua and Dr Boling Qiao) and a PhD student (Ms Julia Langer). She has recently attracted funding from the Barrow UK Neurological Foundation, a sister of the Barrow Neurological Foundation in Phoenix, Arizona to appoint a further post-doctoral scientist and PhD student in 2014.

Publications

Journals

Khan S, Anichini G, Mian A, et al., 2021, Tonsillar carcinoma spreading metastases to central nervous system –Case report and literature review, Journal of Neurological Surgery Reports, Vol:82, ISSN:2193-6358, Pages:e11-e16

Hajji N, García-Domínguez DJ, Hontecillas-Prieto L, et al., 2021, The bitter side of epigenetics: variability and resistance to chemotherapy, Epigenomics, Vol:13, ISSN:1750-1911, Pages:397-403

Vrettos E, Karampelas T, Sayyad N, et al., 2021, Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable "click" oxime bond tethers and preclinical evaluation against prostate cancer, European Journal of Medicinal Chemistry, Vol:211, ISSN:0223-5234

Tsiailanis AD, Renziehausen A, Karakurt S, et al., 2021, Encapsulation of Small Drugs in a Supramolecule Enhances Solubility, Stability, and Therapeutic Efficacy Against Glioblastoma Multiforme., Methods Mol Biol, Vol:2207, Pages:175-186

Diamantis DA, Oblukova M, Chatziathanasiadou M, et al., 2020, Bioinspired tailoring of fluorogenic thiol responsive antioxidant precursors to protect cells against H2O2-induced DNA damage, Free Radical Biology and Medicine, Vol:160, ISSN:0891-5849, Pages:540-551

More Publications