Imperial College London

ProfessorNagyHabib

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Hepatobiliary Surgery
 
 
 
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Contact

 

+44 (0)20 3313 8574nagy.habib

 
 
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Assistant

 

Mrs Benita White +44 (0)20 3313 2261

 
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Location

 

BN1/17 B BlockHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

431 results found

Mizandari M, Azrumelashvili T, Kumar J, Habib Net al., 2017, Percutaneous Image-Guided Pancreatic Duct Drainage: Technique, Results and Expected Benefits, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, Vol: 40, Pages: 1911-1920, ISSN: 0174-1551

JOURNAL ARTICLE

Mudan S, Kumar J, Mafalda NC, Kusano T, Reccia I, Zanallato A, Dalgleish A, Habib Net al., 2017, Case report on the role of radiofrequency-assisted spleen-preserving surgery for splenic metastasis in the era of check-point inhibitors, MEDICINE, Vol: 96, ISSN: 0025-7974

JOURNAL ARTICLE

Reccia I, Kumar J, Akladios C, Virdis F, Pai M, Habib N, Spalding Det al., 2017, Non-alcoholic fatty liver disease: A sign of systemic disease, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 72, Pages: 94-108, ISSN: 0026-0495

JOURNAL ARTICLE

Reccia I, Kumar J, Kusano T, Zanellato A, Draz A, Spalding D, Habib N, Pai Met al., 2017, A systematic review on radiofrequency assisted laparoscopic liver resection: Challenges and window to excel, SURGICAL ONCOLOGY-OXFORD, Vol: 26, Pages: 296-304, ISSN: 0960-7404

JOURNAL ARTICLE

Vavra P, Roman J, Zonca P, Ihnat P, Nemec M, Kumar J, Habib N, El-Gendi Aet al., 2017, Recent Development of Augmented Reality in Surgery: A Review, JOURNAL OF HEALTHCARE ENGINEERING, ISSN: 2040-2295

JOURNAL ARTICLE

Voutila J, Reebye V, Roberts T, Blakey D, Habib R, Mallappa O, Anjaneyulu M, Jayaprakash A, Huber H, Saetrom P, Rossi J, Habib Net al., 2017, Mechanism and In Vivo Activity of a Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Disease, 20th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Publisher: CELL PRESS, Pages: 34-34, ISSN: 1525-0016

CONFERENCE PAPER

Voutila J, Reebye V, Roberts TC, Protopapa P, Andrikakou P, Blakey DC, Habib R, Huber H, Saetrom P, Rossi JJ, Habib NAet al., 2017, Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer, MOLECULAR THERAPY, Vol: 25, Pages: 2705-2714, ISSN: 1525-0016

JOURNAL ARTICLE

Wong JKL, Mohseni R, Hamidieh AA, MacLaren RE, Habib N, Seifalian AMet al., 2017, Will Nanotechnology Bring New Hope for Gene Delivery?, TRENDS IN BIOTECHNOLOGY, Vol: 35, Pages: 434-451, ISSN: 0167-7799

JOURNAL ARTICLE

Wong JKL, Mohseni R, Hamidieh AA, MacLaren RE, Habib N, Seifalian AMet al., 2017, Limitations in Clinical Translation of Nanoparticle-Based Gene Therapy, TRENDS IN BIOTECHNOLOGY, Vol: 35, Pages: 1124-1125, ISSN: 0167-7799

JOURNAL ARTICLE

Yoon S, Armstrong B, Habib N, Rossi Jet al., 2017, RNA Aptamers Selected Through Blind-SELEX Inhibit Pancreatic Cancer Cell Metastasis and Invasion by Regulating Epithelial Mesenchymal Transition(EMT), 20th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Publisher: CELL PRESS, Pages: 43-43, ISSN: 1525-0016

CONFERENCE PAPER

Yoon S, Armstrong B, Habib N, Rossi JJet al., 2017, Blind SELEX Approach Identifies RNA Aptamers That Regulate EMT and Inhibit Metastasis, MOLECULAR CANCER RESEARCH, Vol: 15, Pages: 811-820, ISSN: 1541-7786

JOURNAL ARTICLE

Yoon S, Huang K-W, Reebye V, Spalding D, Przytycka TM, Wang Y, Swiderski P, Li L, Armstrong B, Reccia I, Zacharoulis D, Dimas K, Kusano T, Shively J, Habib N, Rossi JJet al., 2017, Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth, MOLECULAR THERAPY-NUCLEIC ACIDS, Vol: 6, Pages: 80-88, ISSN: 2162-2531

JOURNAL ARTICLE

Zhao X, Voutila J, Ghobrial S, Habib NA, Reebye Vet al., 2017, Treatment of Liver Cancer by C/EBPA saRNA., Adv Exp Med Biol, Vol: 983, Pages: 189-194, ISSN: 0065-2598

The prognosis for hepatocellular carcinoma (HCC) remains poor and has not improved in over two decades. Most patients with advanced HCC who are not eligible for surgery have limited treatment options due to poor liver function or large, unresectable tumors. Although sorafenib is the standard-of-care treatment for these patients, only a small number respond. For the remaining, the outlook remains bleak. A better approach to target "undruggable" molecular pathways that reverse HCC is therefore urgently needed. Small activating RNAs (saRNAs) may provide a novel strategy to activate expression of genes that become dysregulated in chronic disease. The transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα), a critical regulator of hepatocyte function, is suppressed in many advanced liver diseases. By using an saRNA to activate C/EBPα, we can exploit the cell's own transcription machinery to enhance gene expression without relying on exogenous vectors that have been the backbone of gene therapy. saRNAs do not integrate into the host genome and can be modified to avoid immune stimulation. In preclinical models of liver disease, treatment with C/EBPα saRNA has shown reduction in tumor volume and improvement in serum markers of essential liver function such as albumin, bilirubin, aspartate aminotransferase (AST), and alanine transaminase (ALT). This saRNA that activates C/EBPα for advanced HCC is the first saRNA therapy to have entered a human clinical trial. The hope is that this new tool will help break the dismal 20-year trend and provide a more positive prognosis for patients with severe liver disease.

JOURNAL ARTICLE

Blakey D, Reebye V, Voutila J, Habib R, Saetrom P, Huber H, Huang KW, Rossi J, Habib Net al., 2016, Small activating RNA to CEBPA as a novel therapeutic approach to treat patients with liver cancer, 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Publisher: ELSEVIER SCI LTD, Pages: S149-S149, ISSN: 0959-8049

CONFERENCE PAPER

Clift A, Pai M, Habib N, Senturk H, Laktakia S, Reddy N, Cicinnati V, Kaba I, Beckebaum S, Drymousis P, Kahaleh M, Malczewska A, Zanellato A, Brugge W, Frilling Aet al., 2016, Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Neoplasms, 13th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease, Publisher: KARGER, Pages: 91-91, ISSN: 0028-3835

CONFERENCE PAPER

Frampton AE, Krell J, Prado MM, Gall TMH, Abbassi-Ghadi N, Blanco GDV, Funel N, Giovannetti E, Castellano L, Basyouny M, Habib NA, Kaltsidis H, Vlavianos P, Stebbing J, Jiao LRet al., 2016, Prospective validation of microRNA signatures for detecting pancreatic malignant transformation in endoscopic-ultrasound guided fine-needle aspiration biopsies, ONCOTARGET, Vol: 7, Pages: 28556-28569, ISSN: 1949-2553

JOURNAL ARTICLE

Giglio MC, Giakoustidis A, Draz A, Jawad ZAR, Pai M, Habib NA, Tait P, Frampton AE, Jiao LRet al., 2016, Oncological Outcomes of Major Liver Resection Following Portal Vein Embolization: A Systematic Review and Meta-analysis, ANNALS OF SURGICAL ONCOLOGY, Vol: 23, Pages: 3709-3717, ISSN: 1068-9265

JOURNAL ARTICLE

Giglio MC, Spalding DRC, Giakoustidis A, Le Bian AZ, Jiao LR, Habib NA, Pai Met al., 2016, Meta-analysis of drain amylase content on postoperative day 1 as a predictor of pancreatic fistula following pancreatic resection, BRITISH JOURNAL OF SURGERY, Vol: 103, Pages: 328-336, ISSN: 0007-1323

JOURNAL ARTICLE

Huan H, Wen X, Chen X, Wu L, Liu W, Habib NA, Bie P, Xia Fet al., 2016, C/EBP alpha Short-Activating RNA Suppresses Metastasis of Hepatocellular Carcinoma through Inhibiting EGFR/beta-Catenin Signaling Mediated EMT, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Reebye V, Huang K-W, Czysz K, Ciriello S, Dorman S, Reccia I, Lai HS, Peng L, Kostomitsopoulos N, Nicholls J, Habib R, Tomalia D, Saetrom P, Wilkes E, Cutillas P, Rossi J, Habib Net al., 2016, Hepatocellular Nuclear Factor 4 alpha (HNF-4 alpha) activation by saRNA rescues dyslipidemia and promotes favorable metabolic profile in a high fat diet (HFD) fed rat model., 67th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY, Pages: 794A-794A, ISSN: 0270-9139

CONFERENCE PAPER

Reebye V, Voutila J, Blakey D, Habib R, Mallappa O, Muragundla A, Jayaprakash A, Huber HE, Saetrom P, Rossi J, Habib Net al., 2016, The clinical candidate MTL-CEBPA leads to significant reduction in ascites and improvement in overall survival in a CCl4-induced acute liver failure model., 67th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY, Pages: 1045A-1046A, ISSN: 0270-9139

CONFERENCE PAPER

Yoon S, Huang K-W, Habib N, Rossi Jet al., 2016, Potent Anti-Tumor Effects of ApDCs (Aptamer Drug Conjugates) for Targeted Therapeutics in Pancreatic Cancer, 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Publisher: NATURE PUBLISHING GROUP, Pages: S265-S265, ISSN: 1525-0016

CONFERENCE PAPER

Yoon S, Huang K-W, Reebye V, Mintz P, Tien Y-W, Lai H-S, Saetrom P, Reccia I, Swiderski P, Armstrong B, Jozwiak A, Spalding D, Jiao L, Habib N, Rossi JJet al., 2016, Targeted Delivery of C/EBP alpha -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth In Vivo, MOLECULAR THERAPY, Vol: 24, Pages: 1106-1116, ISSN: 1525-0016

JOURNAL ARTICLE

Blagden SP, Rizzuto I, Stavraka C, O'Shea D, Suppiah P, Patel M, Loyse N, Sukumaran A, Bharwani N, Rockall A, Gabra H, El-Bahrawy M, Wasan HS, Leonard RCF, Habib NA, McGuigan C, Gribben JG, Ghazaly EAet al., 2015, A first in human Phase I/II study of NUC-1031 in patients with advanced gynecological cancers., Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Clinical Science Symposium on Predicting and Improving Adverse Outcomes in Older Adults with Cancer, Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X

CONFERENCE PAPER

Blagden SP, Rizzuto I, Stavraka C, O'Shea D, Suppiah P, Patel M, Sukumaran A, Loyse N, Bharwani N, Rockall A, Gabra H, El-Bahrawy M, Wasan H, Leonard RCF, Habib NA, Gribben JG, Ghazaly EA, McGuigan Cet al., 2015, Final results of ProGem1, the first in-human phase I/II study of NUC-1031 in patients with solid malignancies., Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Clinical Science Symposium on Predicting and Improving Adverse Outcomes in Older Adults with Cancer, Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X

CONFERENCE PAPER

Cheng Z, Lv Y, Pang S, Bai R, Wang M, Lin S, Xu T, Spalding D, Habib N, Xu Ret al., 2015, Kallistatin, a new and reliable biomarker for the diagnosis of liver cirrhosis, ACTA PHARMACEUTICA SINICA B, Vol: 5, Pages: 194-200, ISSN: 2211-3835

JOURNAL ARTICLE

Frampton AE, Castellano L, Colombo T, Giovannetti E, Krell J, Jacob J, Pellegrino L, Roca-Alonso L, Funel N, Gall TMH, Ahmad R, Habib NA, Knoesel T, Stebbing J, Jiao LRet al., 2015, Integrated molecular analysis to investigate the role of microRNAs in pancreatic tumour growth and progression, LANCET, Vol: 385, Pages: 37-37, ISSN: 0140-6736

JOURNAL ARTICLE

Frampton AE, Krell J, Jamieson NB, Gall TMH, Giovannetti E, Funel N, Prado MM, Krell D, Habib NA, Castellano L, Jiao LR, Stebbing Jet al., 2015, microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis, EUROPEAN JOURNAL OF CANCER, Vol: 51, Pages: 1389-1404, ISSN: 0959-8049

JOURNAL ARTICLE

Gall TMH, Sodergren MH, Frampton AE, Fan R, Spalding DR, Habib NA, Pai M, Jackson JE, Tait P, Jiao LRet al., 2015, Radio-frequency-assisted Liver Partition With Portal Vein Ligation (RALPP) for Liver Regeneration, ANNALS OF SURGERY, Vol: 261, Pages: E45-E46, ISSN: 0003-4932

JOURNAL ARTICLE

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