ProfessorNagyHabib

Badia JM, Ayton CL, Evans TJ, Carpenter AJ, Nawfal G, Kinderman H, Zografos G, Uemoto S, Cohen J, Habib NAet al., 1998, Systemic cytokine response to hepatic resections under total vascular exclusion, EUROPEAN JOURNAL OF SURGERY, Vol: 164, Pages: 185-190, ISSN: 1102-4151

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• Citations: 35

Brancatisano R, Isla A, Habib N, 1998, Is radical hepatic surgery safe?, AMERICAN JOURNAL OF SURGERY, Vol: 175, Pages: 161-163, ISSN: 0002-9610

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• Citations: 50

Habib NA, Mitry RR, Sadri R, 1998, p53 and gene therapy for hepatocellular carcinoma, GENE THERAPY OF CANCER, Vol: 451, Pages: 499-504, ISSN: 0065-2598

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• Citations: 6

Habib NA, El-Masry R, Mitry RR, Michail NE, Abdel-Ghaffar Y, Moenis Aet al., 1998, Preliminary results of Intratumoral plasmid p53 injection in patients with localised hepatocellular carcinoma, 8th World Congress of the International Gastro-Surgical Club, Publisher: MEDIMOND S R L, Pages: 375-387

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Zografos GN, Palmer S, Papastratis G, Habib NAet al., 1997, Aggressive surgical management of fibrolamellar hepatocellular carcinoma in puberty, EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, Vol: 23, Pages: 570-572, ISSN: 0748-7983

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• Citations: 9

Wu CG, Habib NA, Mitry RR, Reitsma PH, vanDeventer SJH, Chamuleau RAFMet al., 1997, Overexpression of hepatic prothymosin alpha, a novel marker for human hepatocellular carcinoma, BRITISH JOURNAL OF CANCER, Vol: 76, Pages: 1199-1204, ISSN: 0007-0920

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• Citations: 56

Mitry RR, Sarraf CE, Wu CG, Pignatelli M, Habib NAet al., 1997, Wild-type p53 induces apoptosis in Hep3B through up-regulation of bax expression, LABORATORY INVESTIGATION, Vol: 77, Pages: 369-378, ISSN: 0023-6837

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• Citations: 30

Isla AM, Ferrara A, Badia JM, Holloway I, Tanaka H, Riaz A, Habib NAet al., 1997, Fibrolamellar hepatocellular carcinoma: results of partial liver resection, REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, Vol: 89, Pages: 703-705, ISSN: 1130-0108

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• Citations: 2

Martínez Isla A, Ferrara A, Badia JM, Holloway I, Tanaka H, Riaz A, Habib NAet al., 1997, Fibrolamellar hepatocellular carcinoma: results of partial liver resection., Rev Esp Enferm Dig, Vol: 89, Pages: 699-705, ISSN: 1130-0108

AIM: To assess the results of partial hepatic resection in the treatment of fibrolamellar hepatocellular carcinoma. PATIENTS AND RESULTS: We present six cases of Fibrolamellar hepatocellular carcinoma treated by partial hepatic resection. There were five females and one male with a mean age of 20 (2.6) yr. Five patients were stage IVA and 1 IVB based on the Union International Against Cancer Classification. Two patients, due to recurrent disease, needed further pulmonary resection and a hilar lymphadenectomy. All six cases underwent major resection, three with vascular reconstruction. No operative mortality was recorded; half of the patients displayed some degree of morbidity. One patient died six months after the operation and the rest are alive at 78, 41, 24, 12 and 9 months. We believe that even in advanced cases, an aggressive surgical policy even with vascular reconstruction is justified in patients with fibrolamellar hepatocellular carcinoma.

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Wu CG, Habib NA, Mitry RR, Reitsma PH, vanDeventer SJH, Chamuleau RAFMet al., 1997, Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol: 11, Pages: 187-192, ISSN: 1019-6439

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• Citations: 5

See CG, Sud R, Wells D, Bowles L, Ding SF, Habib N, Delhanty JDAet al., 1997, APC gene mutation and DNA microsatellite instability in pancreatic cancers of UK origin, GI CANCER, Vol: 2, Pages: 133-137, ISSN: 1064-9700

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Poole S, Batchelor WH, Ashton MD, Habib NA, Pignatelli Met al., 1997, Immunohistochemical expression of the E-cadherin-catenin complex in primary hepatocellular fibrolamellar and cholangiocarcinomas, JOURNAL OF PATHOLOGY, Vol: 181, Pages: A37-A37, ISSN: 0022-3417

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Aspinall RJ, Seery JP, TaylorRobinson SD, Habib Net al., 1996, Arterialization of the portal vein in orthotopic and auxiliary liver transplantation - Comment, TRANSPLANTATION, Vol: 62, Pages: 1375-1375, ISSN: 0041-1337

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• Citations: 22

Aspinall RJ, Seery JP, Taylor-Robinson SD, Habib Net al., 1996, Comments on "arterialization of the portal vein in orthotopic and auxiliary liver transplantation"., Transplantation, Vol: 62, Pages: 1375-1376, ISSN: 0041-1337

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Moussa ME, Sarraf CE, Uemoto S, Sawada H, Habib NAet al., 1996, Effect of total hepatic vascular exclusion during liver resection on hepatic ultrastructure., Liver Transpl Surg, Vol: 2, Pages: 461-467, ISSN: 1074-3022

The aim of this investigation was to observe ultrastructural changes in the liver in response to warm ischemia during liver surgery. In 11 noncirrhotic patients, hepatic resection was performed under total vascular exclusion (TVE). The mean duration of warm ischemia was 28 minutes (range 16-48 minutes). Three specimens were taken from each patient: before clamping, at the end of TVE, and after reperfusion. Biopsy specimens were studied by light microscopy and by transmission electron microscopy (EM). At the end of the ischemic phase sinusoids were collapsed with resultant loss of normal hepatic architecture. Morphological changes to hepatocytes included focal chromatin condensation at the nuclear margins, distended nuclear envelope, and swelling of both mitochondria and endoplasmic reticulum. After reperfusion these changes reversed. The phenomenon of sinusoidal and hepatocellular recovery after TVE was seen in all the cases of this study, irrespective of age, sex, disease, type and severity of surgical intervention, and duration of TVE. It can be concluded that TVE over a period of 48 minutes has no irreversible deleterious effects on the ultrastructure of the noncirrhotic liver.

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Bower M, Newlands ES, Habib N, 1996, Fibrolamellar hepatocellular carcinoma responsive to platinum-based combination chemotherapy., Clin Oncol (R Coll Radiol), Vol: 8, Pages: 331-333, ISSN: 0936-6555

A patient with advanced unresectable fibrolamellar hepatocellular carcinoma is reported, who was treated with cisplatinum, epirubicin and 5-fluorouracil combination chemotherapy. Tumour regression was achieved, enabling major debulking surgery to be performed. The patient remains in clinical remission 11 months after completing therapy.

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Moussa ME, Isla AM, Sarraf CE, Uemoto S, Sawada H, Habib NAet al., 1996, Effect of total vascular exclusion during liver resection on hepatic ultrastructure, 2nd World Congress of the International-Hepato-Pancreato-Biliary-Association, Publisher: MONDUZZI EDITORE, Pages: 405-409

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Habib NA, Ding SF, ElMasry R, Mitry RR, Honda K, Michail NE, DallaSerra G, Izzi G, Greco L, Bassyouni M, ElToukhy M, AbdelGaffar Yet al., 1996, Preliminary report: The short-term effects of direct p53 DNA injection in primary hepatocellular carcinomas, CANCER DETECTION AND PREVENTION, Vol: 20, Pages: 103-107, ISSN: 0361-090X

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• Citations: 41

Habib NA, Michail NE, Smith P, 1996, The use of hypothermia and circulatory arrest to control intraoperative bleeding from the inferior vena cava, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, Vol: 26, Pages: 217-218, ISSN: 0941-1291

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• Citations: 7

Uemoto S, Martin AJ, Fleming W, Habib NAet al., 1995, The use of transjugular intrahepatic portosystemic shunt and surgical portocaval H-shunt for the treatment of colorectal variceal bleeding, HEPATO-GASTROENTEROLOGY, Vol: 42, Pages: 557-560, ISSN: 0172-6390

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• Citations: 10

MOUSSA ME, BEAN AG, HABIB NA, 1995, REPEATED RESECTION FOR MALIGNANT LIVER-TUMORS, ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, Vol: 77, Pages: 364-368, ISSN: 0035-8843

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• Citations: 5

Habib NA, 1995, Early mortality in 100 consecutive liver resections in 96 patients with benign and malignant liver tumours., Ann R Coll Surg Engl, Vol: 77, Pages: 107-110, ISSN: 0035-8843

This report describes the mortality in 100 liver resections performed in 96 patients for seven benign and 93 malignant liver tumours. Repeat hepatectomy was performed in four patients who developed recurrences after the first liver resection. Two patients died within 30 days. The first was a 67-year-old man who died on the 2nd postoperative day from cardiac failure. The second was a 69-year-old man who died on the 4th postoperative day with liver failure caused by hepatic vascular ischaemia. There were four other hospital deaths at days 33, 40, 45 and 50. A 65-year-old lady died on day 40 from sepsis caused by small bowel infarction. A 30-year-old man died on the 33rd postoperative day owing to liver failure from accelerated hepatic lymphoma spread. A 71-year-old diabetic lady died on the 45th postoperative day from sepsis caused by an untreated subphrenic abscess. A 65-year-old lady died on day 50 from systemic candidiasis after adult respiratory distress syndrome (ARDS). Further reduction in operative mortality could be achieved by better patient selection. Liver resection still remains a major operation, but has become a safe surgical procedure.

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HABIB N, TANAKA K, 1995, LIVING-RELATED LIVER-TRANSPLANTATION IN ADULT RECIPIENTS - A HYPOTHESIS, CLINICAL TRANSPLANTATION, Vol: 9, Pages: 31-34, ISSN: 0902-0063

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• Citations: 29

DING SF, HABIB NA, 1995, LOSS OF HETEROZYGOSITY IN LIVER-TUMORS, JOURNAL OF HEPATOLOGY, Vol: 22, Pages: 230-238, ISSN: 0169-5185

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• Citations: 27

HABIB NA, 1995, LIVER RESECTION WITH TOTAL VASCULAR EXCLUSION FOR MALIGNANT-TUMORS - REPLY, BRITISH JOURNAL OF SURGERY, Vol: 82, Pages: 139-139, ISSN: 0007-1323

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UEMOTO S, FLEMING W, KEOGH BE, HABIB NAet al., 1995, COMBINED PULMONARY TUMOR EMBOLECTOMY AND EXTENDED RIGHT HEPATECTOMY WITH INFERIOR VENA-CAVA RESECTION FOR ADVANCED HEPATOCELLULAR-CARCINOMA, BRITISH JOURNAL OF SURGERY, Vol: 82, Pages: 127-128, ISSN: 0007-1323

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• Citations: 1

Koh MK, Ahmad H, Watanapa P, Jalleh RP, Habib NAet al., 1994, Beware the Anomalous Portal Vein, HPB Surgery, Vol: 7, Pages: 237-240, ISSN: 1607-8462

Portal vein thrombosis is an unusual potential complication of liver resection. In our case it was due to ligation of the right branch of the portal vein during right hepatectomy in a patient without portal vein bifurcation. Hepatic angiography can delineate this abnormality and influence the choice of surgical management.

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HABIB N, ZOGRAFOS G, DALLASERRA G, GRECO L, BEAN Aet al., 1994, LIVER RESECTION WITH TOTAL VASCULAR EXCLUSION FOR MALIGNANT-TUMORS, BRITISH JOURNAL OF SURGERY, Vol: 81, Pages: 1181-1184, ISSN: 0007-1323

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• Citations: 34

CARDOSO JE, GIROUX L, KASSISSIA I, HOUSSIN D, HABIB N, HUET PMet al., 1994, LIVER-FUNCTION IMPROVEMENT FOLLOWING INCREASED PORTAL BLOOD-FLOW IN CIRRHOTIC RATS, GASTROENTEROLOGY, Vol: 107, Pages: 460-467, ISSN: 0016-5085

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• Citations: 27

Habib NA, Cerný J, Danninger F, 1994, [Total vascular exclusion of the liver--an advance in hepatic surgery]., Rozhl Chir, Vol: 73, Pages: 221-222, ISSN: 0035-9351

The authors present the technique of total vascular exclusion of the liver. The main indication for resection of the liver by this technique are central and dorsal tumours, and it can be used successfully also in cases of risky dissection of the hepatic veins. Thermal ischaemia lasting up to one hour proved safe. Total vascular exclusion is a safe and useful technique in major resections of the liver even in case of infiltration of the hepatic veins and the vena cava inferior.

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