Publications
535 results found
Banerjee S, Bentley P, Hamady M, et al., 2014, Intra-Arterial Immunoselected CD34+ Stem Cells for Acute Ischemic Stroke, Stem Cells Transl Med, Vol: pii: sctm.2013-0178. [Epub ahead of print]
Gall TMH, Basyouny M, Frampton AE, et al., 2014, Neoadjuvant chemotherapy and primary-first approach for rectal cancer with synchronous liver metastases, COLORECTAL DISEASE, Vol: 16, Pages: O197-O205, ISSN: 1462-8910
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- Citations: 9
Ghazaly EA, Rizzuto I, Gabra H, et al., 2014, ProGem1: A phase I/II study of a first-in-class nucleotide, Acelarin, in patients with advanced solid tumors, 50th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
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- Citations: 1
Sethi A, Ellrichmann M, Dhar S, et al., 2014, Endoscopic ultrasound-guided lymph node ablation with a novel radiofrequency ablation probe: feasibility study in an acute porcine model, ENDOSCOPY, Vol: 46, Pages: 411-415, ISSN: 0013-726X
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- Citations: 15
Yoon S, Huang K-W, Mintz P, et al., 2014, The Bi-Functional RNA Aptamers Inhibit Pancreatic Ductal Adenocarcinoma (PDAC) Growth <i>In Vivo</i>, 17th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Publisher: NATURE PUBLISHING GROUP, Pages: S301-S301, ISSN: 1525-0016
Vavra P, Penhaker M, Grepl J, et al., 2014, Technical Development of a New Semispherical Radiofrequency Bipolar Device (RONJA): Ex Vivo and In Vivo Studies, BioMed Research International, Vol: 2014, ISSN: 2314-6141
The aim of this study is to inform about the development of a new semispherical surgical instrument for the bipolar multielectrode radiofrequency liver ablation. Present tools are universal; however they have several disadvantages such as ablation of healthy tissue, numerous needle punctures, and, therefore, longer operating procedure. Our newly designed and tested semispherical surgical tool can solve some of these disadvantages. By conducting an in vivo study on a set of 12 pigs, randomly divided into two groups, we have compared efficiency of the newly developed instrument with the commonly used device. Statistical analysis showed that there were no significant differences between the groups. On average, the tested instrument RONJA had shorter ablation time in both liver lobes and reduced the total operating time. The depth of the thermal alteration was on average 4 mm larger using the newly tested instrument. The new radiofrequency method described in this study could be used in open liver surgery for the treatment of small liver malignancies (up to 2 cm) in a single application with the aim of saving healthy liver parenchyma. Further experimental studies are needed to confirm these results before clinical application of the method in the treatment of human liver malignancies.
Pai M, Valek V, Andrasina T, et al., 2014, Percutaneous Intraductal Radiofrequency Ablation for Clearance of Occluded Metal Stent in Malignant Biliary Obstruction: Feasibility and Early Results, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, Vol: 37, Pages: 235-240, ISSN: 0174-1551
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- Citations: 32
Mintz PJ, Huang K-W, Reebye V, et al., 2014, Exploiting human CD34(+) stem cell-conditioned medium for tissue repair, Molecular Therapy, Vol: 22, Pages: 149-159, ISSN: 1525-0016
Despite the progress in our understanding of genes essential for stem cell regulation and development, little is known about the factors secreted by stem cells and their effect on tissue regeneration. In particular, the factors secreted by human CD34+ cells remain to be elucidated. We have approached this challenge by performing a cytokine/growth factor microarray analysis of secreted soluble factors in medium conditioned by adherent human CD34+ cells. Thirty-two abundantly secreted factors have been identified, all of which are associated with cell proliferation, survival, tissue repair, and wound healing. The cultured CD34+ cells expressed known stem cell genes such as Nanog, Oct4, Sox2, c-kit, and HoxB4. The conditioned medium containing the secreted factors prevented cell death in liver cells exposed to liver toxin in vitro via inhibition of the caspase-3 signaling pathway. More importantly, in vivo studies using animal models of liver damage demonstrated that injection of the conditioned medium could repair damaged liver tissue (significant reduction in the necroinflammatory activity), as well as enable the animals to survive. Thus, we demonstrate that medium conditioned by human CD34+ cells has the potential for therapeutic repair of damaged tissue in vivo.
Reebye V, Saetrom P, Mintz PJ, et al., 2014, A Novel RNA Oligonucleotide Improves Liver Function and Inhibits Liver Carcinogenesis In Vivo, HEPATOLOGY, Vol: 59, Pages: 216-227, ISSN: 0270-9139
Banerjee S, Bentley P, Hamady M, et al., 2014, Intra-arterial immunoselected CD34+ stem cells for acute ischemic stroke, Stem Cells Translational Medicine, Vol: 3, Pages: 1322-1331, ISSN: 2157-6564
Treatment with CD34+ hematopoietic stem/progenitor cells has been shown to improve functional recovery in nonhuman models of ischemic stroke via promotion of angiogenesis and neurogenesis. We aimed to determine the safety and feasibility of treatment with CD34+ cells delivered intraarterially in patients with acute ischemic stroke. This was the first study in human subjects. We performed a prospective, nonrandomized, open-label, phase I study of autologous, immunoselected CD34+ stem/progenitor cell therapy in patients presenting within 7 days of onset with severe anterior circulation ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score ‡8). CD34+ cells were collected from the bone marrow of the subjects before being delivered by catheter angiography into the ipsilesional middle cerebral artery. Eighty-two patients with severe anterior circulation ischemic stroke were screened, of whom five proceeded to treatment. The common reasons for exclusion were age >80 years (n = 19); medical instability (n = 17), and significant carotid stenosis (n = 13). The procedure was well tolerated in all patients, and no significant treatment-related adverse effects occurred. All patients showed improvements in clinical functional scores (Modified Rankin Score and NIHSS score) and reductions in lesion volume during a 6-month follow-up period. Autologous CD34+ selected stem/progenitor cell therapy delivered intra-arterially into the infarct territory can be achieved safely in patients with acute ischemic stroke. Future studies that address eligibility criteria, dosage, delivery site, and timing and that use surrogate imaging markers of outcome are desirable before larger scale clinical trials.
Frampton AE, Castellano L, Colombo T, et al., 2014, MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression, GASTROENTEROLOGY, Vol: 146, Pages: 268-+, ISSN: 0016-5085
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- Citations: 132
Gall TMH, Frampton AE, Krell J, et al., 2013, Cell-free DNA for the detection of pancreatic, liver and upper gastrointestinal cancers: has progress been made?, FUTURE ONCOLOGY, Vol: 9, Pages: 1861-1869, ISSN: 1479-6694
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- Citations: 5
Huang KW, Reebye V, Mintz PJ, et al., 2013, Short activating RNA (saRNA) targeting C/EBPA significantly inhibits cell proliferation of undifferentiated cancer cells., MOLECULAR CANCER THERAPEUTICS, Vol: 12, ISSN: 1535-7163
Fotopoulou C, Spiers L, Adjogatse D, et al., 2013, Management of ascites via the alfa-pump closed system in platinum-resistant-ovarian-cancer (PROC): A model of sequential non-invasive tumor-cell sampling through the urinary bladder, CLINICAL CANCER RESEARCH, Vol: 19, ISSN: 1078-0432
Fotopoulou C, Spiers L, Pickford E, et al., 2013, CONTINUOUS LOW-FLOW ASCITES-DRAINAGE AND SEQUENTIAL NON-INVASIVE TUMOR-CELL SAMPLING THROUGH THE URINARY BLADDER VIA THE ALFA-PUMP CLOSED SYSTEM IN PLATINUM-RESISTANT-OVARIAN-CANCER (PROC), INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 23, ISSN: 1048-891X
Shrestha AK, Pai M, Jiao LR, et al., 2013, Resection margin status and long-term outcome using radiofrequency energy as a resection tool for colorectal liver metastases, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY-BLACKWELL, Pages: 128-129, ISSN: 0007-1323
Pai M, Yang J, Zhang X, et al., 2013, ENDOSCOPIC ULTRASOUND GUIDED RADIOFREQUENCY ABLATION (EUS-RFA) FOR PANCREATIC DUCTAL ADENOCARCINOMA, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A153-A153, ISSN: 0017-5749
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- Citations: 13
Zacharoulis D, Sioka E, Tzovaras G, et al., 2013, Laparoscopic Left Lateral Sectionectomy with the Use of Habib 4X: Technical Aspects, JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES, Vol: 23, Pages: 549-552, ISSN: 1092-6429
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- Citations: 12
Mizandari M, Pai M, Xi F, et al., 2013, Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results, CardioVascular and Interventional Radiology, ISSN: 0174-1551
Kallis Y, Phillips N, Steel A, et al., 2013, ANALYSIS OF LONG-TERM OUTCOMES AFTER ENDOSCOPIC RADIOFREQUENCY ABLATION FOR BILE DUCT STRICTURES IN PANCREATIC MALIGNANCY SUGGESTS POTENTIAL SURVIVAL BENEFIT, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A32-A32, ISSN: 0017-5749
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- Citations: 1
Fotopoulou C, Spiers L, Pickford E, et al., 2013, Continuous low-flow ascites drainage and sequential non-invasive tumor-cell sampling through the urinary bladder via the alfa-pump closed system in platinum-resistant ovarian cancer (PROC): First clinical experience in a cancer patient., 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
Christophides T, Frampton AE, Cohen P, et al., 2013, Reactive lymphoid hyperplasia of the pancreas: a clinical conundrum., JOP, Vol: 14, Pages: 207-211
CONTEXT: Localized reactive lymphoid hyperplasia is a rare condition characterized by the presence of lymphoid follicles. CASE REPORT: We describe a case of a 60-year-old woman who presented with right upper quadrant pain and was found to have a reactive nodular hyperplasia of the pancreas involving the uncinate process, body and tail of the gland. Due to the multifocal distribution of these hypoechoic vascular lesions, a total pancreatectomy was performed since malignancy could not be safely excluded. CONCLUSION: There have been a handful of cases reporting reactive lymphoid hyperplasia affecting the pancreas; however, it is uncommon to perform such a radical pancreatic resection for this benign condition.
Zacharoulis D, Lazoura O, Sioka E, et al., 2013, Habib EndoHPB: A Novel Endobiliary Radiofrequency Ablation Device. An Experimental Study, JOURNAL OF INVESTIGATIVE SURGERY, Vol: 26, Pages: 6-10, ISSN: 0894-1939
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- Citations: 31
Deisseroth A, Tang Y, Zhang L, et al., 2013, TAA/ecdCD40L adenoviral prime-protein boost vaccine for cancer and infectious diseases, CANCER GENE THERAPY, Vol: 20, Pages: 65-69, ISSN: 0929-1903
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- Citations: 9
Drymousis P, Pai M, Spalding D, et al., 2013, Is octreotide beneficial in patients undergoing pancreaticoduodenectomy? Best evidence topic (BET), INTERNATIONAL JOURNAL OF SURGERY, Vol: 11, Pages: 779-782, ISSN: 1743-9191
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- Citations: 8
Figueroa-Barojas P, Bakhru MR, Habib NA, et al., 2013, Safety and efficacy of radiofrequency ablation in the management of unresectable bile duct and pancreatic cancer: a novel palliation technique., J Oncol, Vol: 2013, ISSN: 1687-8450
UNLABELLED: Objectives. Radiofrequency ablation (RFA) has replaced photodynamic therapy for premalignant and malignant lesions of the esophagus. However, there is limited experience in the bile duct. The objective of this pilot study was to assess the safety and efficacy of RFA in malignant biliary strictures. METHODS: Twenty patients with unresectable malignant biliary strictures underwent RFA with stenting between June 2010 and July 2012. Diameters of the stricture before and after RFA, immediate and 30 day complications and stent patency were recorded prospectively. Results. A total of 25 strictures were treated. Mean stricture length treated was 15.2 mm (SD = 8.7 mm, Range = 3.5-33 mm). Mean stricture diameter before RFA was 1.7 mm (SD = 0.9 mm, Range = 0.5-3.4 mm) while the mean diameter after RFA was 5.2 mm (SD = 2 mm, Range = 2.6-9 mm). There was a significant increase of 3.5 mm (t = 10.8, DF = 24, P value = <.0001) in the bile duct diameter post RFA. Five patients presented with pain after the procedure, but only one developed mild post-ERCP pancreatitis and cholecystitis. CONCLUSIONS: Radiofrequency ablation can be a safe palliation option for unresectable malignant biliary strictures. A multicenter randomized controlled trial is required to confirm the long term benefits of RFA and stenting compared to stenting alone.
Ghazali E, Joel S, Gribben J, et al., 2013, ProGem1: Phase I first-in- human study of the novel nucleotide NUC-1031 in adult patients with advanced solid tumors., 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), AMER SOC CLINICAL ONCOLOGY
Tan YLJ, Habib NA, Chen WN, 2012, A Quantitative Proteomics Approach in the Study of MicroRNA 181a in HepG2 Cells, CURRENT PROTEOMICS, Vol: 9, Pages: 262-271, ISSN: 1570-1646
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- Citations: 2
Zhang Y, Frampton AE, Martin JL, et al., 2012, 18F-fluorodeoxyglucose positron emission tomography in management of pancreatic cystic tumors, NUCLEAR MEDICINE AND BIOLOGY, Vol: 39, Pages: 982-985, ISSN: 0969-8051
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- Citations: 8
Zhang Y, Frampton AE, Cohen P, et al., 2012, Tumor Infiltration in the Medial Resection Margin Predicts Survival After Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma, JOURNAL OF GASTROINTESTINAL SURGERY, Vol: 16, Pages: 1875-1882, ISSN: 1091-255X
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- Citations: 47
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