ProfessorNagyHabib

Elgendi A, Vavra P, ElKayal E, Habib N, Baki NAet al., 2010, RADIOFREQUENCY ASSISTED HEPATIC RESECTION: A NEW TECHNIQUE USING A BIPOLAR DEVICE, 45th Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S189-S189, ISSN: 0168-8278

• Author Web Link
• Cite
• Citations: 1

Frampton AE, Mamidanna R, MacDonald N, Habib N, Nouraei SARet al., 2010, A multidisciplinary audit of clinical coding accuracy in hepatopancreatobiliary (HPB) surgery, Electronic Poster of Distinction in Association-of-Surgeons-of-Great-Britain-and-Ireland-International-Surgical-Congress, Publisher: WILEY-BLACKWELL, Pages: 39-39, ISSN: 0007-1323

• Author Web Link
• Cite

Jiao LR, Apostolopoulos C, Jacob J, Szydlo R, Johnson N, Tsim N, Habib NA, Coombes RC, Stebbing Jet al., 2009, Unique Localization of Circulating Tumor Cells in Patients With Hepatic Metastases, Journal of Clinical Oncology, Vol: 27, Pages: 6160-6165, ISSN: 0732-183X

PurposeThere are few data on the impact of immediate and differing surgical interventions on circulating tumorcells (CTCs), nor their compartmentalization or localization in different anatomic vascular sites.Patients and MethodsCTCs from consecutive patients with colorectal liver metastases were quantified before andimmediately after open surgery, laparoscopic resection, open radiofrequency ablation (RFA), orpercutaneous RFA. For individuals undergoing open surgery, either hepatic resections or openRFA, CTCs were examined in both systemic and portal circulation by measuring CTCs in samplesderived from the peripheral vein, an artery, the hepatic portal vein, and the hepatic vein.ResultsA total of 29 consecutive patients with colorectal liver metastases with a median age of 55 years(range, 30 to 88 years) were included. CTCs were localized to the hepatic portosystemicmacrocirculation with significantly greater numbers than in the systemic vasculature. Surgicalprocedures led to a statistically significant fall in CTCs at multiple sites measured. Conversely,RFA, either open or percutaneous, was associated with a significant increase in CTCs.ConclusionSurgical resection of metastases, but not RFA, immediately decreases CTC levels. In patients withcolorectal liver metastases, CTCs appear localized to the hepatic (and pulmonary) macrocirculations.This may explain why metastases in sites other than the liver and lungs are infrequentlyobserved in cancer.

• Abstract
• Open Access Link
• Cite

Sommerville CAM, Limongelli P, Pai M, Ahmad R, Stamp G, Habib NA, Williamson RCN, Jiao LRet al., 2009, Survival Analysis After Pancreatic Resection for Ampullary and Pancreatic Head Carcinoma: An Analysis of Clinicopathological Factors, JOURNAL OF SURGICAL ONCOLOGY, Vol: 100, Pages: 651-656, ISSN: 0022-4790

• Author Web Link
• Cite
• Citations: 60

Pai M, Helmy S, Jiao LR, Levicar N, Tait P, Marley SB, Thillainayagam A, Bansi D, Nicholls JP, Jensen S, Gordon MY, Habib NAet al., 2009, Clinical application of adult bone marrow-derived stem cell progenitors, Combined Meeting of the 17th European-Society-of-Gene-and-Cell-Therapy/16th German-Society-for-Gene-Therapy/4th German-Society-for-Stem-Cell-Research, Publisher: MARY ANN LIEBERT INC, Pages: 1367-1367, ISSN: 1043-0342

• Author Web Link
• Cite

Seaton T, Naji M, Tait P, Nijran K, Habib N, Wasan H, AL-Nahhas Aet al., 2009, Selective Internal Radiotherapy for Unresectable Liver Tumours: Follow Up Of 74 Cases, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 36, Pages: S230-S230, ISSN: 1619-7070

• Author Web Link
• Cite

Popescu I, Habib N, Dima S, Hancu N, Gherghe L, Iacon S, Mihaila M, Dorobantu B, Matei E, Botea Fet al., 2009, Domino liver transplantation using a graft from a donor with familial hupercholesterolaemia: Seven year follow-up., Clinical Transplantation, Vol: 23, Pages: 565-570

• Cite

Curro G, Bartolotta M, Jiao L, Habib N, Navarra Get al., 2009, Ultrasound-guided radiofrequency-assisted segmental liver resection: a new technique., Annals of Surgery, Vol: 250, Pages: 229-33

• Cite

Zacharoulis D, Khorsandi SE, Vavra P, Dostalik J, Navarra G, Nicholls JP, Jiao LR, Habib NAet al., 2009, Pilot study for a new bipolar radiofrequency ablation/aspirator device in the management of primary and secondary liver cancers, LIVER INTERNATIONAL, Vol: 29, Pages: 824-830, ISSN: 1478-3223

• Author Web Link
• Cite
• Citations: 10

Khorsandi SE, Kysela P, Valek V, Olufemi OMS, Lazar I, Prochazka V, Zacharoulis D, Rountas C, Habib NAet al., 2009, Initial data on a novel endovascular radiofrequency catheter when used for arterial occlusion in liver cancer, EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA, Vol: 41, Pages: 104-108, ISSN: 1682-8631

• Author Web Link
• Cite
• Citations: 4

Wang QZ, Xu W, Habib N, Zu Ret al., 2009, Potential uses if microRNA in lung cancer diagnosis, prognosis and therapy, Current Cancer Drug Targets, Vol: 9, Pages: 572-594

• Cite

Jiao L, Apostolopoulos C, Jacob J, Johnson N, Tsim N, Habib N, Coombes R, Stebbing Jet al., 2009, The anatomic localization of circulating tumor cells and the immediate impact of surgery and radiofrequency ablation., J Clin Oncol, Vol: 27

e22004 Background: There are few data on the impact of immediate and differing surgical interventions on circulating tumor cells (CTCs), nor their compartmentalization or localization in different anatomic vascular sites. METHODS: CTCs from consecutive patients with colorectal liver metastases were quantitated prior to and immediately after open surgery, laparoscopic resection, open radiofrequency ablation (RFA) or percutaneous RFA. For individuals undergoing open surgery, either hepatic resections or open RFA, CTCs were examined in both systemic and portal circulation by measuring CTCs in samples derived from the peripheral vein, an artery, the portal vein and hepatic vein. RESULTS: A total of 29 consecutive patients with colorectal liver metastases were included with a median age of 55 (range 30 - 88 years). CTCs were localized to the hepatic portosystemic macrocirculation with significantly greater numbers than in the systemic vasculature. Surgical procedures led to a statistically significant fall in CTCs at all sites measured (p<0.05). Conversely, RFA, either open or percutaneous was associated with an increase in CTCs. CONCLUSIONS: Surgical resection of metastases but not RFA decreases CTC levels. In patients with colorectal liver metastases, CTCs are localized to the hepatic (and probably pulmonary) macrocirculations. This may explain why metastases in sites other than the liver and lungs, are infrequently observed in cancer. No significant financial relationships to disclose.

• Abstract
• Author Web Link
• Cite

du Potet E, Germain C, Harbottle R, Gordon M, Habib N, Levicar Net al., 2009, Oxaliplatin chemoresistant CaCO-2 cells do not exhibit primitive cancer stem cell-like characteristics., CANCER RESEARCH, Vol: 69, ISSN: 0008-5472

• Author Web Link
• Cite

Limongelli P, Pai M, Damrah O, Lauretta A, Atijosan O, Habib N, Jiao LRet al., 2009, Cystic Tumors of the Biliary Tract: A Complete Excision Is Crucial, INTERNATIONAL SURGERY, Vol: 94, Pages: 136-140, ISSN: 0020-8868

• Author Web Link
• Cite
• Citations: 5

Limongelli P, Pai M, Damrah O, Lauretta A, Atijosan O, Habib N, Jiao Let al., 2009, Cystic tumors of the biliary tract: a complete excision is crucial, International Surgery, Vol: 94, Pages: 136-140

• Cite

Vavra P, Dostalik J, Vavrova M, Gunkova P, Pai M, El-Gendi A, Habib N, Papaevangelou Aet al., 2009, Transanal endoscopic microsurgery: A novel technique for the repair of benign retrovaginal fistula, SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND, Vol: 7, Pages: 126-127, ISSN: 1479-666X

• Author Web Link
• Cite
• Citations: 14

Aloysius MM, Mc Kechnie AJ, Robins RA, Verma C, Eremin JM, Farzaneh F, Habib NA, Bhalla J, Hardwick NR, Satthaporn S, Sreenivasan T, El-Sheemy M, Eremin Oet al., 2009, Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs, Journal of Translational Medicine, Vol: 7, ISSN: 1479-5876

BackgroundOptimal techniques for DC generation for immunotherapy in cancer are yet to be established. Study aims were to evaluate: (i) DC activation/maturation milieu (TNF-α +/- IFN-α) and its effects on CD8+ hTERT-specific T cell responses to class I epitopes (p540 or p865), (ii) CD8+ hTERT-specific T cell responses elicited by vaccination with class I alone or both class I and II epitope (p766 and p672)-pulsed DCs, prepared without IFN-α, (iii) association between circulating T regulatory cells (Tregs) and clinical responses.MethodsAutologous DCs were generated from 10 patients (HLA-0201) with advanced cancer by culturing CD14+ blood monocytes in the presence of GM-CSF and IL-4 supplemented with TNF-α [DCT] or TNF-α and IFN-α [DCTI]. The capacity of the DCs to induce functional CD8+ T cell responses to hTERT HLA-0201 restricted nonapeptides was assessed by MHC tetramer binding and peptide-specific cytotoxicity. Each DC preparation (DCT or DCTI) was pulsed with only one type of hTERT peptide (p540 or p865) and both preparations were injected into separate lymph node draining regions every 2–3 weeks. This vaccination design enabled comparison of efficacy between DCT and DCTI in generating hTERT peptide specific CD8+ T cells and comparison of class I hTERT peptide (p540 or p865)-loaded DCT with or without class II cognate help (p766 and p672) in 6 patients. T regulatory cells were evaluated in 8 patients.Results(i) DCTIs and DCTs, pulsed with hTERT peptides, were comparable (p = 0.45, t-test) in inducing peptide-specific CD8+ T cell responses. (ii) Class II cognate help, significantly enhanced (p < 0.05, t-test) peptide-specific CD8+T cell responses, compared with class I pulsed DCs alone. (iii) Clinical responders had significantly lower (p < 0.05, Mann-Whitney U test) T regs, compared with non-responders. 4/16 patients experienced partial but transient clinical responses during vaccination. Vaccination was well tolera

• Abstract
• Open Access Link
• Cite

Flinterman M, Farzaneh F, Habib N, Malik F, Gaken J, Tavassoli Met al., 2009, Delivery of Therapeutic Proteins as Secretable TAT Fusion Products, MOLECULAR THERAPY, Vol: 17, Pages: 334-342, ISSN: 1525-0016

• Author Web Link
• Cite
• Citations: 52

Vavra P, Dostalik J, Zacharoulis D, Khorsandi SE, Khan SA, Habib NAet al., 2009, Endoscopic Radiofrequency Ablation in Colorectal Cancer: Initial Clinical Results of a New Bipolar Radiofrequency Ablation Device, DISEASES OF THE COLON & RECTUM, Vol: 52, Pages: 355-358, ISSN: 0012-3706

• Author Web Link
• Cite
• Citations: 19

Dimarakis I, 2009, Handbook of Cardiac Stem Cell Therapy, Publisher: Imperial College Press, ISBN: 9781848162570

This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world.

• Abstract
• Cite

Levicar N, Dimarakis I, Flores C, Prodromidi EI, Gordon MY, Habib NAet al., 2009, Stem Cells and Organ Replacement, ARTIFICIAL ORGANS, Editors: Hakim, Publisher: SPRINGER-VERLAG LONDON LTD, Pages: 137-163, ISBN: 978-1-84882-281-8

• Author Web Link
• Cite
• Citations: 2

Curro G, Habib N, Jiao L, Baccarani U, Scisca C, Navarra Get al., 2008, Radiofrequency-assisted liver resection in patients with hepatocellular carcinoma and cirrhosis: preliminary results, Transplant Proceedings, Vol: 40, Pages: 3523-3525

• Cite

Curro G, Jiao L, Baccarani U, Scisca C, Mucciardi M, Navarra Get al., 2008, Radiofrequency-assisted liver resection in cirrhotic patients with hepatocellular carcinoma, Journal of Surgical Oncology, Vol: 98, Pages: 407-410

• Cite

Jiao LR, Ayav A, Navarra G, Sommerville C, Pai M, Damrah O, Khorsandi S, Habib NAet al., 2008, Laparoscopic liver resection assisted by the laparoscopic Habib Sealer, SURGERY, Vol: 144, Pages: 770-774, ISSN: 0039-6060

• Author Web Link
• Cite
• Citations: 15

P Limongelli, SE Khorsandi, M Pai, JE Jackson, P Tait, J Tierris, RCN Williamson, Limongelli P, Khorsandi SE, Pai M, Jackson JE, Tait P, Tierris J, Williamson RCN, Habib NA, Jiao LRet al., 2008, Management of delayed postoperative haemorrhage after pancreaticoduodenectomy: A meta-analysis, Arch Surg

• Cite

Khorsandi SE, Zacharoulis D, Vavra P, Navarra G, Kysela P, Habib Net al., 2008, Moderne Anwendung der Radiofrequenzenergie in Chirurgie, Endoskopie und interventioneller Radiologie, EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA, Vol: 40, Pages: 204-210, ISSN: 1682-8631

• Author Web Link
• Cite
• Citations: 22

Magnusson MK, Ohno I, Kraaij R, van Weerden WM, Myhre S, Habib NA, Kasahara N, Lindholm Let al., 2008, Transductionally retargeted Adenovirus vectors for tumor treatment, 16th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 1077-1077, ISSN: 1043-0342

• Author Web Link
• Cite

Mintz PJ, Habib NA, Jones JL, Giamas G, Lewis JS, Bowen RL, Coombes RC, Stebbing Jet al., 2008, The phosphorylated membrane estrogen receptor and cytoplasmic signaling and apoptosis proteins in human breast cancer, CANCER, Vol: 113, Pages: 1489-1495, ISSN: 0008-543X

• Author Web Link
• Cite
• Citations: 15

Damrah O, Bansi D, Habib N, Wasan H, Canelo R, Jiao Let al., 2008, Treatment of liver metastasis from Gastrointestinal Stromal Tumours: multimodal approach, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 23, Pages: A44-A45, ISSN: 0815-9319

• Author Web Link
• Cite

Damrah OM, Bansi D, Tait P, Habib N, Canelo R, Jiao Let al., 2008, Repeat trans-arterial chemoembolisation for unresectable hepatocellular carcinoma: efficacy and long-term survival, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 23, Pages: A43-A44, ISSN: 0815-9319

• Author Web Link
• Cite