Imperial College London
Alternate

Professor Neil Ferguson

Faculty of Medicine, School of Public Health

Director of the School of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 3296neil.ferguson Website

 
 
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Location

 

508School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ferguson:2016:10.1126/science.aaf9590,
author = {Ferguson, NM and Rodriguez-Barraquer, I and Dorigatti, I and Mier-y-Teran-Romero, L and Laydon, DJ and Cummings, DAT},
doi = {10.1126/science.aaf9590},
journal = {Science},
pages = {1033--1036},
title = {Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment},
url = {http://dx.doi.org/10.1126/science.aaf9590},
volume = {353},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The first approved dengue vaccine has now been licensed in six countries. We propose that this live attenuated vaccine acts like a silent natural infection in priming or boosting host immunity. A transmission dynamic model incorporating this hypothesis fits recent clinical trial data well and predicts that vaccine effectiveness depends strongly on the age group vaccinated and local transmission intensity. Vaccination in low-transmission settings may increase the incidence of more severe “secondary-like” infection and, thus, the numbers hospitalized for dengue. In moderate transmission settings, we predict positive impacts overall but increased risks of hospitalization with dengue disease for individuals who are vaccinated when seronegative. However, in high-transmission settings, vaccination benefits both the whole population and seronegative recipients. Our analysis can help inform policy-makers evaluating this and other candidate dengue vaccines.
AU  - Ferguson,NM
AU  - Rodriguez-Barraquer,I
AU  - Dorigatti,I
AU  - Mier-y-Teran-Romero,L
AU  - Laydon,DJ
AU  - Cummings,DAT
DO  - 10.1126/science.aaf9590
EP  - 1036
PY  - 2016///
SN  - 0036-8075
SP  - 1033
TI  - Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment
T2  - Science
UR  - http://dx.doi.org/10.1126/science.aaf9590
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268127/?tool=nihms
UR  - http://hdl.handle.net/10044/1/45746
VL  - 353
ER  -
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