Imperial College London
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ProfessorNickOliver

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Wynn Chair in Human Metabolism (Clinical)
 
 
 
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Contact

 

+44 (0)20 7594 1796nick.oliver

 
 
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Location

 

7S7aCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rilstone:2019:10.1089/dia.2019.0079,
author = {Rilstone, S and Reddy, M and Oliver, N},
doi = {10.1089/dia.2019.0079},
journal = {Diabetes Technology and Therapeutics},
pages = {452--455},
title = {Glycemic index, extended bolusing, and diabetes education in insulin pump therapy (GLIDE: A pilot study)},
url = {http://dx.doi.org/10.1089/dia.2019.0079},
volume = {21},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: There is no published evidence on whether advanced bolus education affects outcomes in insulin pump-treated type 1 diabetes. We assess the feasibility of delivering a clinical education program on rates of digestion and bolusing, and to assess its preliminary impact.Methods: An interactive education session on glycemic index (GI), extended bolusing, and superbolusing was developed and assessed in a nonrandomized single-arm study for 12 weeks. Insulin pump-treated participants with type 1 diabetes were recruited. Glucose outcomes were assessed by blinded continuous glucose monitoring after the consumption of high-fat and high-GI test meal. The primary outcome measure was 8-h glucose area under the curve (AUC) after high-fat meals, before and after intervention. Secondary outcomes included time spent in hypoglycemia, quality of life, treatment satisfaction, HbA1c, frequency of use of extended boluses, and postprandial AUC.Results: Eleven participants completed the study [mean (SD) age 42.3 (12.8) years, baseline HbA1c 57.3 (10.0) mmol/mol, duration of diabetes 19.5 (9.9) years]. AUC for glucose after test meals did not differ significantly after education except for in the first 2 h after the high-GI meal [precourse 83.1 (0.23–88.9), postcourse 5.38 (−16.2 to 50.8)]. Percentage time spent in hypoglycemia (<3.9 and <3.3 mmol/L) fell at week 12 compared with baseline [5.8 (IQR 2.1–8.3) % to 4.3 (IQR 2.1–5.4) %, P = 0.013, and 2.9 (IQR 1.2–3.9) % to 1.6 (IQR 0.7–2.4) %, P = 0.029, respectively].Conclusion: Delivering an education program to support advanced boluses is feasible and may reduce exposure to hypoglycemia. A further trial is required to confirm the findings.
AU  - Rilstone,S
AU  - Reddy,M
AU  - Oliver,N
DO  - 10.1089/dia.2019.0079
EP  - 455
PY  - 2019///
SN  - 1520-9156
SP  - 452
TI  - Glycemic index, extended bolusing, and diabetes education in insulin pump therapy (GLIDE: A pilot study)
T2  - Diabetes Technology and Therapeutics
UR  - http://dx.doi.org/10.1089/dia.2019.0079
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000469512700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.liebertpub.com/doi/10.1089/dia.2019.0079
UR  - http://hdl.handle.net/10044/1/74017
VL  - 21
ER  -
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