Imperial College London
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ProfessorNickOliver

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Wynn Chair in Human Metabolism (Clinical)
 
 
 
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Contact

 

+44 (0)20 7594 1796nick.oliver

 
 
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Location

 

7S7aCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Guemes:2020:10.1007/s11154-020-09548-7,
author = {Guemes, M and Rahman, SA and Kapoor, RR and Flanagan, S and Houghton, JAL and Misra, S and Oliver, N and Dattani, MT and Shah, P},
doi = {10.1007/s11154-020-09548-7},
journal = {Reviews in Endocrine and Metabolic Disorders},
pages = {577--597},
title = {Hyperinsulinemic hypoglycemia in children and adolescents: Recent advances in understanding of pathophysiology and management},
url = {http://dx.doi.org/10.1007/s11154-020-09548-7},
volume = {21},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release, leading to persistently low blood glucose concentrations with lack of alternative fuels, which increases the risk of neurological damage in these patients. It is the most common cause of persistent and recurrent hypoglycemia in the neonatal period. HH may be primary, Congenital HH (CHH), when it is associated with variants in a number of genes implicated in pancreatic development and function. Alterations in fifteen genes have been recognized to date, being some of the most recently identified mutations in genes HK1, PGM1, PMM2, CACNA1D, FOXA2 and EIF2S3. Alternatively, HH can be secondary when associated with syndromes, intra-uterine growth restriction, maternal diabetes, birth asphyxia, following gastrointestinal surgery, amongst other causes. CHH can be histologically characterized into three groups: diffuse, focal or atypical. Diffuse and focal forms can be determined by scanning using fluorine-18 dihydroxyphenylalanine-positron emission tomography. Newer and improved isotopes are currently in development to provide increased diagnostic accuracy in identifying lesions and performing successful surgical resection with the ultimate aim of curing the condition. Rapid diagnostics and innovative methods of management, including a wider range of treatment options, have resulted in a reduction in co-morbidities associated with HH with improved quality of life and long-term outcomes. Potential future developments in the management of this condition as well as pathways to transition of the care of these highly vulnerable children into adulthood will also be discussed.
AU  - Guemes,M
AU  - Rahman,SA
AU  - Kapoor,RR
AU  - Flanagan,S
AU  - Houghton,JAL
AU  - Misra,S
AU  - Oliver,N
AU  - Dattani,MT
AU  - Shah,P
DO  - 10.1007/s11154-020-09548-7
EP  - 597
PY  - 2020///
SN  - 1389-9155
SP  - 577
TI  - Hyperinsulinemic hypoglycemia in children and adolescents: Recent advances in understanding of pathophysiology and management
T2  - Reviews in Endocrine and Metabolic Disorders
UR  - http://dx.doi.org/10.1007/s11154-020-09548-7
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000520650900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs11154-020-09548-7
UR  - http://hdl.handle.net/10044/1/84101
VL  - 21
ER  -
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