Imperial College London
Alternate

Professor Nimalan Arinaminpathy (Nim Pathy)

Faculty of Medicine, School of Public Health

Professor in Mathematical Epidemiology
 
 
 
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Contact

 

nim.pathy Website

 
 
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Location

 

Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Faria:2014:10.1126/science.1256739,
author = {Faria, NR and Rambaut, A and Suchard, MA and Baele, G and Bedford, T and Ward, MJ and Tatem, AJ and Sousa, JD and Arinaminpathy, N and Pepin, J and Posada, D and Peeters, M and Pybus, OG and Lemey, P},
doi = {10.1126/science.1256739},
journal = {Science},
pages = {56--61},
title = {The early spread and epidemic ignition of HIV-1 in human populations},
url = {http://dx.doi.org/10.1126/science.1256739},
volume = {346},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Thirty years after the discovery of HIV-1, the early transmission, dissemination, and establishment of the virus in human populations remain unclear. Using statistical approaches applied to HIV-1 sequence data from central Africa, we show that from the 1920s Kinshasa (in what is now the Democratic Republic of Congo) was the focus of early transmission and the source of pre-1960 pandemic viruses elsewhere. Location and dating estimates were validated using the earliest HIV-1 archival sample, also from Kinshasa. The epidemic histories of HIV-1 group M and nonpandemic group O were similar until ~1960, after which group M underwent an epidemiological transition and outpaced regional population growth. Our results reconstruct the early dynamics of HIV-1 and emphasize the role of social changes and transport networks in the establishment of this virus in human populations.
AU  - Faria,NR
AU  - Rambaut,A
AU  - Suchard,MA
AU  - Baele,G
AU  - Bedford,T
AU  - Ward,MJ
AU  - Tatem,AJ
AU  - Sousa,JD
AU  - Arinaminpathy,N
AU  - Pepin,J
AU  - Posada,D
AU  - Peeters,M
AU  - Pybus,OG
AU  - Lemey,P
DO  - 10.1126/science.1256739
EP  - 61
PY  - 2014///
SN  - 0036-8075
SP  - 56
TI  - The early spread and epidemic ignition of HIV-1 in human populations
T2  - Science
UR  - http://dx.doi.org/10.1126/science.1256739
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342446900048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://science.sciencemag.org/content/346/6205/56
VL  - 346
ER  -
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