Imperial College London

Mr Oliver Boughton

Faculty of MedicineDepartment of Surgery & Cancer

Clinical Research Fellow
 
 
 
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Contact

 

o.boughton

 
 
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Location

 

The MSk LabCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

15 results found

Soukup B, Bishomun S, Boughton OR, Tennant Det al., Improving Undergraduate Orthopedic Surgery Skills and Knowledge in a One Day Course, Medical Science Educator

JOURNAL ARTICLE

Arnold M, Zhao S, Ma S, Giuliani F, Hansen U, Cobb JP, Abel RL, Boughton Oet al., 2017, Microindentation - a tool for measuring cortical bone stiffness? A systematic review., Bone Joint Res, Vol: 6, Pages: 542-549, ISSN: 2046-3758

OBJECTIVES: Microindentation has the potential to measure the stiffness of an individual patient's bone. Bone stiffness plays a crucial role in the press-fit stability of orthopaedic implants. Arming surgeons with accurate bone stiffness information may reduce surgical complications including periprosthetic fractures. The question addressed with this systematic review is whether microindentation can accurately measure cortical bone stiffness. METHODS: A systematic review of all English language articles using a keyword search was undertaken using Medline, Embase, PubMed, Scopus and Cochrane databases. Studies that only used nanoindentation, cancellous bone or animal tissue were excluded. RESULTS: A total of 1094 abstracts were retrieved and 32 papers were included in the analysis, 20 of which used reference point indentation, and 12 of which used traditional depth-sensing indentation. There are several factors that must be considered when using microindentation, such as tip size, depth and method of analysis. Only two studies validated microindentation against traditional mechanical testing techniques. Both studies used reference point indentation (RPI), with one showing that RPI parameters correlate well with mechanical testing, but the other suggested that they do not. CONCLUSION: Microindentation has been used in various studies to assess bone stiffness, but only two studies with conflicting results compared microindentation with traditional mechanical testing techniques. Further research, including more studies comparing microindentation with other mechanical testing methods, is needed before microindentation can be used reliably to calculate cortical bone stiffness.Cite this article: M. Arnold, S. Zhao, S. Ma, F. Giuliani, U. Hansen, J. P. Cobb, R. L. Abel, O. Boughton. Microindentation - a tool for measuring cortical bone stiffness? A systematic review. Bone Joint Res 2017;6:542-549. DOI: 10.1302/2046-3758.69.BJR-2016-0317.R2.

JOURNAL ARTICLE

Boughton OR, Zhao S, Arnold M, Ma S, Cobb JP, Giuliani F, Hansen U, Abel RLet al., 2017, Measuring bone stiffness using microindentation, British Orthopaedic Research Society (BORS) 2016 Conference, Publisher: British Editorial Society of Bone and Joint Surgery, Pages: 31-31, ISSN: 2049-4416

CONFERENCE PAPER

Ma S, Goh EL, Jin A, Bhattacharya R, Boughton OR, Patel B, Karunaratne A, Vo NT, Atwood R, Cobb JP, Hansen U, Abel RLet al., 2017, Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Ridzwan MIZ, Sukjamsri C, Pal B, van Arkel RJ, Bell A, Khanna M, Baskaradas A, Abel R, Boughton O, Cobb J, Hansen UNet al., 2017, Femoral fracture type can be predicted from femoral structure: A finite element study validated by digital volume correlation experiments., J Orthop Res

Proximal femoral fractures can be categorized into two main types: Neck and intertrochanteric fractures accounting for 53% and 43% of all proximal femoral fractures, respectively. The possibility to predict the type of fracture a specific patient is predisposed to would allow drug and exercise therapies, hip protector design, and prophylactic surgery to be better targeted for this patient rendering fracture preventing strategies more effective. This study hypothesized that the type of fracture is closely related to the patient-specific femoral structure and predictable by finite element (FE) methods. Fourteen femora were DXA scanned, CT scanned, and mechanically tested to fracture. FE-predicted fracture patterns were compared to experimentally observed fracture patterns. Measurements of strain patterns to explain neck and intertrochanteric fracture patterns were performed using a digital volume correlation (DVC) technique and compared to FE-predicted strains and experimentally observed fracture patterns. Although loaded identically, the femora exhibited different fracture types (six neck and eight intertrochanteric fractures). CT-based FE models matched the experimental observations well (86%) demonstrating that the fracture type can be predicted. DVC-measured and FE-predicted strains showed obvious consistency. Neither DXA-based BMD nor any morphologic characteristics such as neck diameter, femoral neck length, or neck shaft angle were associated with fracture type. In conclusion, patient-specific femoral structure correlates with fracture type and FE analyses were able to predict these fracture types. Also, the demonstration of FE and DVC as metrics of the strains in bones may be of substantial clinical value, informing treatment strategies and device selection and design. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

JOURNAL ARTICLE

Ma S, Boughton O, Karunaratne A, Jin A, Cobb J, Hansen U, Abel Ret al., 2016, Synchrotron Imaging Assessment of Bone Quality, CLINICAL REVIEWS IN BONE AND MINERAL METABOLISM, Vol: 14, Pages: 150-160, ISSN: 1534-8644

JOURNAL ARTICLE

Ma S, Goh EL, Patel B, Jin A, Boughton O, Cobb J, Hansen U, Abel RLet al., 2016, Are the cracks starting to appear in bisphosphonate therapy?, British Orthopaedic Research Society (BORS) 2016 Conference, Publisher: British Editorial Society of Bone and Joint Surgery, Pages: 53-53, ISSN: 2049-4416

CONFERENCE PAPER

Boughton OR, Bernard J, Szarko M, 2015, Odontoid process fractures: the role of the ligaments in maintaining stability. A biomechanical, cadaveric study, SICOT-J, Vol: 1, Pages: 11-11

JOURNAL ARTICLE

Crossley KM, Callaghan MJ, van Linschoten R, 2015, Patellofemoral pain, BMJ, Pages: h3939-h3939

JOURNAL ARTICLE

Khatib M, Soukup B, Boughton O, Amin K, Davis CR, Evans DMet al., 2015, Plastic Surgery Undergraduate Training, Annals of Plastic Surgery, Vol: 75, Pages: 208-212, ISSN: 0148-7043

JOURNAL ARTICLE

Lazic S, Boughton O, Hing C, Bernard Jet al., 2014, Arthroscopic washout of the knee: A procedure in decline, The Knee, Vol: 21, Pages: 631-634, ISSN: 0968-0160

JOURNAL ARTICLE

Boughton O, Borgulya G, Cecconi M, Fredericks S, Moreton-Clack M, MacPhee IAMet al., 2013, A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients., Br J Clin Pharmacol, Vol: 76, Pages: 425-431

AIMS: An algorithm based on the CYP3A5 genotype to predict tacrolimus clearance to inform the optimal initial dose was derived using data from the DeKAF study (Passey et al. Br J Clin Pharmacol 2011; 72: 948-57) but was not tested in an independent cohort of patients. Our aim was to test whether the DeKAF dosing algorithm could predict estimated tacrolimus clearance in renal transplant recipients at our centre. METHODS: Predicted tacrolimus clearance based on the DeKAF algorithm was compared with dose-normalized trough whole-blood concentrations (estimated clearance) on day 7 after transplantation in a single-centre cohort of 255 renal transplant recipients. RESULTS: There was a weak correlation (r = 0.431) between clearance based on dose-normalized trough whole-blood concentrations and DeKAF algorithm-predicted clearance. The means of the tacrolimus clearance predicted by the DeKAF algorithm and the estimated tacrolimus clearance based on the dose-normalized trough blood concentrations were plotted against the differences in the clearance as a Bland-Altman plot. Logarithmic transformation was performed owing to the increased difference in tacrolimus clearance as the mean clearance increased. There was a highly significant systematic error (P < 0.0005) characterized by a sloped regression line [gradient, 0.88 (95% confidence interval, 0.75-1.01)] on the Bland-Altman plot. CONCLUSIONS: The DeKAF algorithm was unable to predict the estimated tacrolimus clearance accurately based on real tacrolimus doses and blood concentrations in our cohort of patients. Other genes are known to influence the clearance of tacrolimus, and a polygenic algorithm may be more predictive than those based on a single genotype.

JOURNAL ARTICLE

Boughton OR, Mackenzie H, 2012, Osteoarthritis of the Trapeziometacarpal Joint (TMJ): A Review of the Literature, Osteoarthritis- Diagnosis, Treatment and Surgery

BOOK CHAPTER

Boughton O, Adds PJ, Jayasinghe JAP, 2010, The potential complications of open carpal tunnel release surgery to the ulnar neurovascular bundle and its branches: A cadaveric study, Clinical Anatomy, Vol: 23, Pages: 545-551, ISSN: 0897-3806

JOURNAL ARTICLE

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