Imperial College London
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Mr Oliver Boughton

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Research Fellow
 
 
 
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Contact

 

o.boughton

 
 
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Location

 

The MSk LabCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ma:2016:10.1007/s12018-016-9223-3,
author = {Ma, S and Boughton, O and Karunaratne, A and Jin, A and Cobb, JP and Hansen, U and Abel, RL},
doi = {10.1007/s12018-016-9223-3},
journal = {Clinical Reviews in Bone and Mineral Metabolism},
pages = {150--160},
title = {Synchrotron imaging assessment of bone quality},
url = {http://dx.doi.org/10.1007/s12018-016-9223-3},
volume = {14},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bone is a complex hierarchical structure and its principal function is to resist mechanical forces and fracture. Bone strength depends not only on the quantity of bone tissue but also on the shape and hierarchical structure. The hierarchical levels are interrelated, especially the micro-architecture, collagen and mineral components; hence analysis of their specic roles in bone strength and stiffness is difficult. Synchrotron imaging technologies including micro-CT and small/wide angle X-Ray scattering/diffraction are becoming increasingly popular for studying bone because the images can resolve deformations in the micro-architecture and collagen-mineral matrix under in situ mechanical loading. Synchrotron cannot be directly applied in-vivo due to the high radiation dose but will allow researchers to carry out systematic multifaceted studies of bone ex-vivo. Identifying characteristics of aging and disease will underpin future efforts to generate novel devices and interventional therapies for assessing and promoting healthy aging. With our own research work as examples, this paper introduces how synchrotron imaging technology can be used with in-situ testing in bone research.
AU  - Ma,S
AU  - Boughton,O
AU  - Karunaratne,A
AU  - Jin,A
AU  - Cobb,JP
AU  - Hansen,U
AU  - Abel,RL
DO  - 10.1007/s12018-016-9223-3
EP  - 160
PY  - 2016///
SN  - 1559-0119
SP  - 150
TI  - Synchrotron imaging assessment of bone quality
T2  - Clinical Reviews in Bone and Mineral Metabolism
UR  - http://dx.doi.org/10.1007/s12018-016-9223-3
UR  - http://hdl.handle.net/10044/1/39235
VL  - 14
ER  -
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