Imperial College London
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Dr Tolga Bozkurt

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Plant-Microbe
 
 
 
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Contact

 

+44 (0)20 7594 5381o.bozkurt

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Leong:2021:10.1101/2021.03.17.435853,
author = {Leong, JX and Raffeiner, M and Spinti, D and Langin, G and Franz-Wachtel, M and Guzman, AR and Kim, J-G and Pandey, P and Minina, AE and Macek, B and Hafrén, A and Bozkurt, TO and Mudgett, MB and Börnke, F and Hofius, D and Üstün, S},
doi = {10.1101/2021.03.17.435853},
title = {A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component},
url = {http://dx.doi.org/10.1101/2021.03.17.435853},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Beyond its role in cellular homeostasis, autophagy plays anti- and pro-microbial roles in host-microbe interactions, both in animals and plants. One prominent role of anti-microbial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although well-described in animals, the extent to which xenophagy contributes to plant-bacteria interactions remains unknown. Here, we provide evidence that <jats:italic>Xanthomonas campestris</jats:italic> pv. <jats:italic>vesicatoria (Xcv)</jats:italic> suppresses host autophagy by utilizing type-III effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defense-related selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in depletion of a bacterial virulence factor and unravels an unprecedented pathogen strategy to counteract defense-related autophagy.</jats:p>
AU  - Leong,JX
AU  - Raffeiner,M
AU  - Spinti,D
AU  - Langin,G
AU  - Franz-Wachtel,M
AU  - Guzman,AR
AU  - Kim,J-G
AU  - Pandey,P
AU  - Minina,AE
AU  - Macek,B
AU  - Hafrén,A
AU  - Bozkurt,TO
AU  - Mudgett,MB
AU  - Börnke,F
AU  - Hofius,D
AU  - Üstün,S
DO  - 10.1101/2021.03.17.435853
PY  - 2021///
TI  - A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component
UR  - http://dx.doi.org/10.1101/2021.03.17.435853
ER  -
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