Imperial College London
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Dr Tolga Bozkurt

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Plant-Microbe
 
 
 
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Contact

 

+44 (0)20 7594 5381o.bozkurt

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dong:2014:10.1126/science.1246300,
author = {Dong, S and Stam, R and Cano, LM and Song, J and Sklenar, J and Yoshida, K and Bozkurt, TO and Oliva, R and Liu, Z and Tian, M and Win, J and Banfield, MJ and Jones, AME and van, der Hoorn RAL and Kamoun, S},
doi = {10.1126/science.1246300},
journal = {SCIENCE},
pages = {552--555},
title = {Effector specialization in a lineage of the Irish potato famine pathogen},
url = {http://dx.doi.org/10.1126/science.1246300},
volume = {343},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.
AU  - Dong,S
AU  - Stam,R
AU  - Cano,LM
AU  - Song,J
AU  - Sklenar,J
AU  - Yoshida,K
AU  - Bozkurt,TO
AU  - Oliva,R
AU  - Liu,Z
AU  - Tian,M
AU  - Win,J
AU  - Banfield,MJ
AU  - Jones,AME
AU  - van,der Hoorn RAL
AU  - Kamoun,S
DO  - 10.1126/science.1246300
EP  - 555
PY  - 2014///
SN  - 0036-8075
SP  - 552
TI  - Effector specialization in a lineage of the Irish potato famine pathogen
T2  - SCIENCE
UR  - http://dx.doi.org/10.1126/science.1246300
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330343700050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://science.sciencemag.org/content/343/6170/552
VL  - 343
ER  -
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