Imperial College London
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Dr Tolga Bozkurt

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Plant-Microbe
 
 
 
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Contact

 

+44 (0)20 7594 5381o.bozkurt

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Giannakopoulou:2014:10.1371/journal.pone.0107462,
author = {Giannakopoulou, A and Schornack, S and Bozkurt, TO and Haart, D and Ro, D-K and Faraldos, JA and Kamoun, S and O'Maille, PE},
doi = {10.1371/journal.pone.0107462},
journal = {PLoS One},
pages = {1--11},
title = {Variation in capsidiol sensitivity between phytophthora infestans and phytophthora capsici is consistent with their host range},
url = {http://dx.doi.org/10.1371/journal.pone.0107462},
volume = {9},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Plants protect themselves against a variety of invading pathogenic organisms via sophisticated defence mechanisms. These responses include deployment of specialized antimicrobial compounds, such as phytoalexins, that rapidly accumulate at pathogen infection sites. However, the extent to which these compounds contribute to species-level resistance and their spectrum of action remain poorly understood. Capsidiol, a defense related phytoalexin, is produced by several solanaceous plants including pepper and tobacco during microbial attack. Interestingly, capsidiol differentially affects growth and germination of the oomycete pathogens Phytophthora infestans and Phytophthora capsici, although the underlying molecular mechanisms remain unknown. In this study we revisited the differential effect of capsidiol on P. infestans and P. capsici, using highly pure capsidiol preparations obtained from yeast engineered to express the capsidiol biosynthetic pathway. Taking advantage of transgenic Phytophthora strains expressing fluorescent markers, we developed a fluorescence-based method to determine the differential effect of capsidiol on Phytophtora growth. Using these assays, we confirm major differences in capsidiol sensitivity between P. infestans and P. capsici and demonstrate that capsidiol alters the growth behaviour of both Phytophthora species. Finally, we report intraspecific variation within P. infestans isolates towards capsidiol tolerance pointing to an arms race between the plant and the pathogens in deployment of defence related phytoalexins.
AU  - Giannakopoulou,A
AU  - Schornack,S
AU  - Bozkurt,TO
AU  - Haart,D
AU  - Ro,D-K
AU  - Faraldos,JA
AU  - Kamoun,S
AU  - O'Maille,PE
DO  - 10.1371/journal.pone.0107462
EP  - 11
PY  - 2014///
SN  - 1932-6203
SP  - 1
TI  - Variation in capsidiol sensitivity between phytophthora infestans and phytophthora capsici is consistent with their host range
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0107462
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342684500102&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107462
UR  - http://hdl.handle.net/10044/1/90282
VL  - 9
ER  -
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