Imperial College London
Alternate

Professor Oscar Ces

Faculty of Natural Sciences, Department of Chemistry

Head of Department, August von Hofmann Chair of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3754o.ces Website

 
 
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Location

 

G04AMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Haylock:2020:10.1038/s42004-020-0322-1,
author = {Haylock, S and Friddin, M and Hindley, J and Rodriguez, E and Charalambous, K and Booth, P and Barter, L and Ces, O},
doi = {10.1038/s42004-020-0322-1},
journal = {Communications Chemistry},
title = {Membrane protein mediated bilayer communication in networks of droplet interface bilayers},
url = {http://dx.doi.org/10.1038/s42004-020-0322-1},
volume = {3},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Droplet interface bilayers (DIBs) are model membranes formed between lipid monolayer-encased water droplets in oil. Compared to conventional methods, one of the most unique properties of DIBs is that they can be connected together to generate multi-layered ‘tissue-like’ networks, however introducing communication pathways between these compartments typically relies on water-soluble pores that are unable to gate. Here, we show that network connectivity can instead be achieved using a water-insoluble membrane protein by successfully reconstituting a chemically activatable mutant of the mechanosensitive channel MscL into a network of DIBs. Moreover, we also show how the small molecule activator can diffuse through an open channel and across the neighbouring droplet to activate MscL present in an adjacent bilayer. This demonstration of membrane protein mediated bilayer communication could prove key toward developing the next generation of responsive bilayer networks capable of defining information flow inside a minimal tissue.
AU  - Haylock,S
AU  - Friddin,M
AU  - Hindley,J
AU  - Rodriguez,E
AU  - Charalambous,K
AU  - Booth,P
AU  - Barter,L
AU  - Ces,O
DO  - 10.1038/s42004-020-0322-1
PY  - 2020///
SN  - 2399-3669
TI  - Membrane protein mediated bilayer communication in networks of droplet interface bilayers
T2  - Communications Chemistry
UR  - http://dx.doi.org/10.1038/s42004-020-0322-1
UR  - http://hdl.handle.net/10044/1/80477
VL  - 3
ER  -
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