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@misc{Tang:2013,
author = {Tang, H and Li, H and Wang, Y and Pardo, OE and Seckl, MJ},
title = {Combined preparation and application of combined preparation in preparing non-small-cell lung carcinoma drug},
type = {Patent},
url = {http://www.pss-system.gov.cn/sipopublicsearch/ensearch/searchEnHomeIndex.shtml?params=991CFE73D4DF553253D44E119219BF31366856FF4B152226CAE4DB031259396A},
year = {2013}
}

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TY  - PAT
AB  - The invention discloses a combined preparation and an application of the combined preparation in preparing a non-small-cell lung carcinoma drug. An EGFR (Epidermal Growth Factor Receptor) tyrosine kinase inhibitor and a preparation for increasing a concentration of glutathione (GSH) in lung carcinoma cells are administered simultaneously or successively. According to the combined preparation and the application, through a systemic research, the GSH plays an important role in resisting the EGFR tyrosine kinase inhibitor to an EGFR T790M mutation non-small-cell lung carcinoma, so that drug resisting cells are sensitive to treatment of the EGFR tyrosine kinase inhibitor again by utilizing a mode of increasing the concentration of the GSH in the lung carcinoma cells; and a cell experiment and an animal experiment prove that the method is safe and effective, can effectively kill the lung carcinoma cells, and can inhibit proliferation of the lung carcinoma cells.
AU  - Tang,H
AU  - Li,H
AU  - Wang,Y
AU  - Pardo,OE
AU  - Seckl,MJ
PY  - 2013///
TI  - Combined preparation and application of combined preparation in preparing non-small-cell lung carcinoma drug
UR  - http://www.pss-system.gov.cn/sipopublicsearch/ensearch/searchEnHomeIndex.shtml?params=991CFE73D4DF553253D44E119219BF31366856FF4B152226CAE4DB031259396A
UR  - http://hdl.handle.net/10044/1/55078
ER  -

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Dr Olivier E. Pardo

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