Oliver Howes is Group Head and Professor of Molecular Psychiatry. His clinical work is as Consultant Psychiatrist at The Institute of Psychiatry/ Maudsley Hospital.
Contact: tel: +44 (0)20 8383 3298
Mental illnesses are a major cause of ill health and premature death. They account for four of the six leading causes of adult disability in the world and one in every ten hospital beds in the UK is allocated for the treatment of psychotic disorders such as schizophrenia.
“Our research focuses on understanding the causes of mental illnesses and improving their treatment using PET and other functional imaging techniques"
Current work in the group focuses on:
- Understanding the brain changes that lead to the development of psychotic disorders, using multi-modal imaging with PET and MRI
- Examining the effects of cannabis and other drugs on the brain, and the influence of common genetic polymorphisms on brain function
- Determining why some patients respond to treatments and others don’t
- Using novel approaches to diagnosing mental illnesses
- Developing models for future drug development
et al., Association of stimulants use with dopaminergic alterations in users of cocaine, amphetamine, or methamphetamine: a systematic review and meta-analysis, Jama Psychiatry, ISSN:2168-6238
et al., 2016, Adversity in childhood linked to elevated striatal dopamine function in adulthood., Schizophr Res, Vol:176, Pages:171-176
et al., 2017, The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia., Biol Psychiatry, Vol:81, Pages:9-20
Howes O, Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology., Journal of Psychopharmacology, ISSN:1461-7285
et al., Phasic stimulation of midbrain dopamine neuron activity reduces salt consumption, Eneuro, ISSN:2373-2822