Imperial College London
Alternate

DrOliverHowes

Faculty of Medicine, Institute of Clinical Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 4318oliver.howes Website

 
 
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Location

 

Steiner MRI UnitHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Reis:2018:10.1017/S0033291718003057,
author = {Reis, Marques T and Ashok, A and Pillinger, T and Veronese, M and Turkheimer, F and Dazzan, P and Sommer, I and Howes, O},
doi = {10.1017/S0033291718003057},
journal = {Psychological Medicine},
pages = {2186--2196},
title = {Neuroinflammation in schizophrenia: meta-analysis of in-vivo microglial imaging studies},
url = {http://dx.doi.org/10.1017/S0033291718003057},
volume = {49},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundConverging lines of evidence implicate an important role for the immune system in schizophrenia. Microglia are the resident immune cells of the central nervous system and have many functions including neuroinflammation, axonal guidance and neurotrophic support. We aimed to provide a quantitative review of in vivo PET imaging studies of microglia activation in patients with schizophrenia compared with healthy controls.MethodsDemographic, clinical and imaging measures were extracted from each study and meta-analysis was conducted using a random-effects model (Hedge's g). The difference in 18-kDa translocator protein (TSPO) binding between patients with schizophrenia and healthy controls, as quantified by either binding potential (BP) or volume of distribution (VT), was used as the main outcome. Sub-analysis and sensitivity analysis were carried out to investigate the effects of genotype, ligand and illness stage.ResultsIn total, 12 studies comprising 190 patients with schizophrenia and 200 healthy controls met inclusion criteria. There was a significant elevation in tracer binding in schizophrenia patients relative to controls when BP was used as an outcome measure, (Hedge's g = 0.31; p = 0.03) but no significant differences when VT was used (Hedge's g = −0.22; p = 0.29).ConclusionsIn conclusion, there is evidence for moderate elevations in TSPO tracer binding in grey matter relative to other brain tissue in schizophrenia when using BP as an outcome measure, but no difference when VT is the outcome measure. We discuss the relevance of these findings as well as the methodological issues that may underlie the contrasting difference between these outcomes.
AU  - Reis,Marques T
AU  - Ashok,A
AU  - Pillinger,T
AU  - Veronese,M
AU  - Turkheimer,F
AU  - Dazzan,P
AU  - Sommer,I
AU  - Howes,O
DO  - 10.1017/S0033291718003057
EP  - 2196
PY  - 2018///
SN  - 0033-2917
SP  - 2186
TI  - Neuroinflammation in schizophrenia: meta-analysis of in-vivo microglial imaging studies
T2  - Psychological Medicine
UR  - http://dx.doi.org/10.1017/S0033291718003057
UR  - https://www.cambridge.org/core/journals/psychological-medicine/article/neuroinflammation-in-schizophrenia-metaanalysis-of-in-vivo-microglial-imaging-studies/991843292F0212960314A007D052003F
UR  - http://hdl.handle.net/10044/1/63327
VL  - 49
ER  -
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