Imperial College London
Alternate

DrOliverHowes

Faculty of Medicine, Institute of Clinical Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 4318oliver.howes Website

 
 
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Location

 

Steiner MRI UnitHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Horder:2018:10.1126/scitranslmed.aam8434,
author = {Horder, J and Andersson, M and Mendez, MA and Singh, N and Tangen, A and Lundberg, J and Gee, A and Halldin, C and Veronese, M and Bolte, S and Farde, L and Sementa, T and Cash, D and Higgins, K and Spain, D and Turkheimer, F and Mick, I and Selvaraj, S and Nutt, DJ and Lingford-Hughes, A and Howes, OD and Murphy, DG and Borg, J},
doi = {10.1126/scitranslmed.aam8434},
journal = {Science Translational Medicine},
title = {GABA(A) receptor availability is not altered in adults with autism spectrum disorder or in mouse models},
url = {http://dx.doi.org/10.1126/scitranslmed.aam8434},
volume = {10},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Preliminary studies have suggested that γ-aminobutyric acid type A (GABAA) receptors, and potentially the GABAA α5 subtype, are deficient in autism spectrum disorder (ASD). However, prior studies have been confounded by the effects of medications, and these studies did not compare findings across different species. We measured both total GABAA and GABAA α5 receptor availability in two positron emission tomography imaging studies. We used the tracer [11C]flumazenil in 15 adults with ASD and in 15 control individuals without ASD and the tracer [11C]Ro15-4513 in 12 adults with ASD and in 16 control individuals without ASD. All participants were free of medications. We also performed autoradiography, using the same tracers, in three mouse models of ASD: the Cntnap2 knockout mouse, the Shank3 knockout mouse, and mice carrying a 16p11.2 deletion. We found no differences in GABAA receptor or GABAA α5 subunit availability in any brain region of adults with ASD compared to those without ASD. There were no differences in GABAA receptor or GABAA α5 subunit availability in any of the three mouse models. However, adults with ASD did display altered performance on a GABA-sensitive perceptual task. Our data suggest that GABAA receptor availability may be normal in adults with ASD, although GABA signaling may be functionally impaired.
AU  - Horder,J
AU  - Andersson,M
AU  - Mendez,MA
AU  - Singh,N
AU  - Tangen,A
AU  - Lundberg,J
AU  - Gee,A
AU  - Halldin,C
AU  - Veronese,M
AU  - Bolte,S
AU  - Farde,L
AU  - Sementa,T
AU  - Cash,D
AU  - Higgins,K
AU  - Spain,D
AU  - Turkheimer,F
AU  - Mick,I
AU  - Selvaraj,S
AU  - Nutt,DJ
AU  - Lingford-Hughes,A
AU  - Howes,OD
AU  - Murphy,DG
AU  - Borg,J
DO  - 10.1126/scitranslmed.aam8434
PY  - 2018///
SN  - 1946-6234
TI  - GABA(A) receptor availability is not altered in adults with autism spectrum disorder or in mouse models
T2  - Science Translational Medicine
UR  - http://dx.doi.org/10.1126/scitranslmed.aam8434
UR  - http://hdl.handle.net/10044/1/64171
VL  - 10
ER  -
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